本文選題：特發(fā)性肺纖維化 + 血府逐瘀膠囊�。� 參考：《中華中醫(yī)藥雜志》2015年02期

【摘要】：目的:觀察血府逐瘀膠囊聯(lián)合N-乙酰半胱氨酸抑制特發(fā)性肺纖維化(IPF)進(jìn)展的有效性和安全性。方法:選擇臨床診斷IPF患者40例,隨機(jī)分為治療組(20例)和對(duì)照組(20例),兩組均予N-乙酰半胱氨酸口服,1片/次,2次/d,治療組聯(lián)合血府逐瘀膠囊口服,5粒/次,2次/d,均治療18個(gè)月,評(píng)價(jià)疾病無(wú)進(jìn)展生存(PFS)率和時(shí)間、IPF急性加重(AE-IPF)發(fā)生率、肺功能(TLC、FVC、DLCO)、6MWT(距離、6MWT前/后Sp O2)、Borg評(píng)分與基線水平差值。結(jié)果:完成研究34例(治療組18例、對(duì)照組16例),治療組PFS率(77.8%)高于對(duì)照組(50.0%),治療組PFS時(shí)間(16.70個(gè)月)高于對(duì)照組(14.16個(gè)月),差異無(wú)統(tǒng)計(jì)學(xué)意義;治療組AEIPF發(fā)生率(5.6%)低于對(duì)照組(12.5%),差異無(wú)統(tǒng)計(jì)學(xué)意義;治療組TLC、FVC、DLCO降低值均低于對(duì)照組,差異無(wú)統(tǒng)計(jì)學(xué)意義,治療組6MWT距離、6MWT后Sp O2降低值均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組6MWT前Sp O2降低值低于對(duì)照組,差異無(wú)統(tǒng)計(jì)學(xué)意義,治療組Borg評(píng)分降低值低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療組不良反應(yīng)發(fā)生率(11.11%)高于對(duì)照組(6.25%),差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論:聯(lián)合治療有減少IPF疾病進(jìn)展和急性加重次數(shù)的趨勢(shì),可減緩肺功能和運(yùn)動(dòng)耐量下降速度。
[Abstract]:Aim: to observe the efficacy and safety of Xuefu Zhuyu capsule combined with N-acetylcysteine in inhibiting the progression of idiopathic pulmonary fibrosis (IPF). Methods: 40 patients with IPF were selected. Two groups were randomly divided into treatment group (n = 20) and control group (n = 20). Both groups were treated with N- acetylcysteine orally for 2 times a day, and the treatment group combined with Xuefu Zhuyu capsule for two times a day for 18 months. The PFSs rate and time of acute exacerbation of IPF were evaluated, and the difference between the baseline level and the lung function of TLCFV / DLCOC / 6MWTwas evaluated. Results: 34 cases (18 cases in the treatment group and 16 cases in the control group) completed the study. The PFS rate of the treatment group was 77.8% higher than that of the control group (50.0%). The PFS time of the treatment group (16.70 months) was higher than that of the control group (14.16 months), and the difference was not statistically significant. The incidence of AEIPF in the treatment group (5.6m) was lower than that in the control group (12.5MWT), the difference was not statistically significant (P < 0.05), the decrease value of AEIPF in the treatment group was lower than that in the control group (P < 0.01), and the decrease value of SPO _ 2 in the treatment group was lower than that in the control group after 6MWT distance was 6MWT. The difference was statistically significant (P 0.05). The decrease of SPO 2 before 6MWT in the treatment group was lower than that in the control group, but the difference was not statistically significant. The Borg score in the treatment group was lower than that in the control group, and the difference was statistically significant (P 0.05). The incidence of adverse reactions in treatment group (11.11) was higher than that in control group (6.25%). Conclusion: combined therapy has a tendency to reduce the progression and acute exacerbation of IPF, and can slow down the decline of pulmonary function and exercise tolerance.
【作者單位】： 天津中醫(yī)藥大學(xué)第一附屬醫(yī)院;
【分類號(hào)】：R563.9

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