本文選題：成人 + 社區(qū)獲得性肺炎��； 參考：《中華醫(yī)院感染學雜志》2014年15期

【摘要】：目的了解煤礦礦區(qū)成人社區(qū)獲得性肺炎(CAP)非典型病原體分布及影響因素,為初始抗感染經(jīng)驗治療提供參考依據(jù)。方法采用多中心調(diào)查的方法,收集2011年10月-2012年9月煤礦礦區(qū)4所醫(yī)院呼吸內(nèi)科102例確診為CAP成人住院患者的臨床資料,并采集急性期和間隔2~4周恢復(fù)期患者的靜脈血進行非典型病原體抗體檢測,應(yīng)用SPSS13.0進行分析。結(jié)果 102例CAP患者檢出非典型病原體18株,陽性率為17.7%,其中肺炎支原體16株占15.7%,肺炎衣原體2株占2.0%;非典型病原體在18~49歲患者中的檢出率高于≥50歲患者;非典型病原體在未合并其他疾病和肺炎嚴重指數(shù)(PORT)Ⅰ級更常見,差異有統(tǒng)計學意義(P0.05)。結(jié)論煤礦礦區(qū)成人CAP患者的非典型病原體以肺炎支原體為主;對18~49歲年齡段、無基礎(chǔ)疾病、PORTⅠ級輕癥CAP患者經(jīng)驗性抗感染治療應(yīng)涵蓋非典型病原體。
[Abstract]:Objective to investigate the distribution and influencing factors of atypical pathogens of adult community acquired pneumonia (CAP) in coal mining area, and to provide reference for initial anti-infection experience therapy.Methods the clinical data of 102 adult inpatients with CAP in respiratory department of 4 coal mine hospitals from October 2011 to September 2012 were collected by multi-center investigation.Venous blood samples were collected from patients in acute stage and convalescent stage at intervals of 2 weeks to detect antibodies against atypical pathogens. SPSS13.0 was used to analyze them.Results 18 strains of atypical pathogens were detected in 102 patients with CAP, the positive rate was 17.7%, including 16 strains of mycoplasma pneumoniae and 2.0 strains of chlamydia pneumoniae, the detection rate of atypical pathogens in 1849 years old patients was higher than that in patients over 50 years old.Atypical pathogens were more common in PORTI without other diseases and pneumonia, and the difference was statistically significant (P 0.05).Conclusion Mycoplasma pneumoniae is the main atypical pathogen in adult CAP patients in coal mining area, and the empirical anti-infection therapy should cover atypical pathogens in patients with CAP with mild CAP without basic disease in the age group of 49 years.
【作者單位】： 河北聯(lián)合大學附屬開灤總醫(yī)院呼吸內(nèi)科;河北聯(lián)合大學附屬開灤總醫(yī)院感染管理科;開灤總醫(yī)院范各莊醫(yī)院兒科;
【基金】：中國煤炭工業(yè)協(xié)會科學技術(shù)研究指導性計劃基金項目(MTKJ2011-459)
【分類號】：R563.1

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