發(fā)布時間：2018-04-05 23:08

  本文選題：咳嗽　切入點：哮喘　出處：《重慶醫(yī)學(xué)》2017年21期

【摘要】：目的考察布地奈德福莫特羅粉吸入劑聯(lián)合中醫(yī)藥辨證治療老年咳嗽變異性哮喘(CVA)的臨床療效。方法將2014年7月至2016年8月青海省中醫(yī)院收治的85例老年CVA患者分為觀察組(43例)與對照組(42例),對照組采用布地奈德福莫特羅粉吸入劑吸入治療,觀察組在對照組基礎(chǔ)上立足于將祛風(fēng)作為首要,同時加用中藥分夾寒、夾熱、夾燥、夾痰等4種證型行辨證治療,兩組患者療程均為14d。比較兩組患者的肺功能指標(biāo)[包括第1秒用力呼氣體積(FEV_1)、FEV_1與用力肺活量(FVC)比值(FEV_1/FVC)及最大呼氣流量(PEF)],血清指標(biāo)[包括白細(xì)胞介素-4/γ-干擾素(IL-4/IFN-γ)比值與IL-17]及臨床療效。結(jié)果治療后,兩組FEV_1、FEV_1/FVC、PEF均較治療前增大,血清IL-4/IFN-γ比值與IL-17水平均較治療前降低,差異均有統(tǒng)計學(xué)意義(P0.05);且治療后觀察組FEV_1、FEV_1/FVC均高于對照組(t=2.549、2.060,P=0.008、0.020),血清IL-4/IFN-γ比值與IL-17水平均低于對照組(t=16.229、4.417,P0.001);觀察組的愈顯率與總有效率分別為76.74%與95.35%,對照組分別為52.38%與78.57%,組間比較差異均有統(tǒng)計學(xué)意義(χ~2=5.522、5.308,P=0.027、0.033)。結(jié)論較單一使用布地奈德福莫特羅粉吸入劑,聯(lián)合中醫(yī)藥辨證治療老年CVA更具優(yōu)勢。
[Abstract]:Objective to investigate the clinical effect of budesonide formoterol powder inhalation combined with traditional Chinese medicine (TCM) in the treatment of senile cough variant asthma (CVA).Methods from July 2014 to August 2016, 85 elderly patients with CVA were divided into observation group (n = 43) and control group (n = 42). The control group was treated with inhaled budesonide formoterol powder.Observation group based on the control group on the basis of dispelling wind as the first, at the same time with traditional Chinese medicine divided into cold, heat, dryness, phlegm, and other four syndrome differentiation treatment, the two groups of patients were treated for 14 days.The pulmonary function indexes (including FEV1 / FEV1 / FEV1 / FVC-1 / FEV1 / FVC-1) and peak expiratory flow (PEFF) were compared between the two groups. The serum indexes [including interleukin-4 / 緯 -interferon IL-4 / IL-4 / IFN- 緯 ratio and IL-17] and clinical efficacy were compared.Results after treatment, the FEV _ 1 / FEV _ 1 / FEV _ 1 / FEV _ 1 / FVCV / PEF in both groups increased, and the ratio of IL-4 / IFN- 緯 and the level of IL-17 in serum decreased compared with those before treatment.The difference was statistically significant (蠂 ~ (2 +) 5.522 ~ (5.308)) (P = 0.027) 0.033 (P < 0.05).Conclusion compared with budesonide formoterol powder inhalation alone and combined with traditional Chinese medicine, the treatment of senile CVA is more advantageous.
【作者單位】： 青海省中醫(yī)院肺病科;成都市溫江區(qū)人民醫(yī)院科教科;
【基金】：成都市衛(wèi)計委醫(yī)學(xué)科研課題基金項目(2015171)
【分類號】：R562.25

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