本文選題：睡眠呼吸暫停　切入點：阻塞性　出處：《中國全科醫(yī)學(xué)》2014年33期 　論文類型：期刊論文

【摘要】：目的探討阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者情緒與血漿5-羥色胺(5-HT)水平的關(guān)系。方法選取2010年6月—2013年6月河北聯(lián)合大學(xué)附屬醫(yī)院呼吸科確診的OSAHS患者121例為OSAHS組,另選擇本院同期體檢的健康人群60例為對照組,采用焦慮自評量表(SAS)判斷有無焦慮,應(yīng)用心境狀態(tài)量表(POMS)評估情緒狀態(tài),采用酶聯(lián)免疫吸附法(ELISA)測定血漿5-HT水平。結(jié)果 OSAHS組POMS評分中緊張-焦慮、憂郁-沮喪、疲憊-惰性評分高于對照組,活力-好動評分低于對照組(P0.05);OSAHS組血漿5-HT水平高于對照組(P0.05)。OSAHS程度與SAS評分呈正相關(guān)(r=0.642,P=0.000);與POMS評分中緊張-焦慮、憂郁-沮喪、疲憊-惰性評分呈正相關(guān)(r=0.515,P=0.000;r=0.526,P=0.000;r=0.318,P=0.018);與活力-好動評分呈負相關(guān)(r=-0.496,P=0.000)。OSAHS病程與SAS評分呈正相關(guān)(r=0.489,P=0.001);與POMS評分中緊張-焦慮、憂郁-沮喪、疲憊-惰性評分呈正相關(guān)(r=0.509,P=0.000;r=0.371,P=0.010;r=0.271,P=0.021);與活力-好動評分呈負相關(guān)(r=-0.474,P=0.000)。OSAHS組63例出現(xiàn)焦慮,發(fā)生率為52.1%;OSAHS患者焦慮組POMS評分中緊張-焦慮、憂郁-沮喪、疲憊-惰性評分高于非焦慮組,活力-好動評分低于非焦慮組(P0.05);焦慮組血漿5-HT水平高于非焦慮組(P0.05)。OSAHS患者血漿5-HT水平與SAS評分呈正相關(guān)(r=0.689,P=0.000);與POMS評分中緊張-焦慮、憂郁-沮喪評分呈正相關(guān)(r=0.522,P=0.000;r=0.548,P=0.000),與活力-好動評分呈負相關(guān)(r=-0.508,P=0.000)。結(jié)論 OSAHS患者可呈現(xiàn)不同的負性情緒,伴有血漿5-HT水平的升高;OSAHS患者的焦慮情緒變化與5-HT變化水平有關(guān)。
[Abstract]:Objective to investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) and plasma 5- in patients with emotional serotonin (5-HT) levels in patients with OSAHS. Methods from June 2010 to June 2013 the Affiliated Hospital of Hebei United University Department of respiration diagnosed 121 cases of OSAHS group, another choice of healthy people at the same period in hospital physical examination of 60 cases as control group, using the the self rating Anxiety Scale (SAS) to determine the presence of anxiety, mood state scale (POMS) assessment of emotional state, using enzyme-linked immunosorbent assay (ELISA) for determination of plasma levels of 5-HT. Results OSAHS group POMS score in tension anxiety, depressed depression, fatigue inertia score higher than the control group, restless vitality the score lower than the control group (P0.05 5-HT); the level of plasma OSAHS was higher than the control group (P0.05).OSAHS level were positively correlated with SAS score (r=0.642, P=0.000); tension and POMS score in anxiety, depression, depression, fatigue inertia score was Related (r=0.515, P=0.000; r=0.526, P=0.000; r=0.318, P=0.018); and the activity of activity score was negatively correlated (r=-0.496, P=0.000) related to the course of.OSAHS were positively correlated with SAS score (r=0.489, P=0.001); tension and POMS score in anxiety, depression, depression, fatigue inertia scores were positively related (r=0.509, P=0.000; r=0.371, P=0.010; r=0.271, P=0.021); and the activity of activity score was negatively correlated (r=-0.474, P=0.000) in 63 cases of anxiety in.OSAHS group, the incidence rate was 52.1%; OSAHS group POMS score in patients with anxiety and tension anxiety, depression, depression, fatigue inertia score higher than non anxiety group were lower than those of non - active, energetic the anxiety group (P0.05); the 5-HT level of plasma anxiety is higher than non anxiety group (P0.05) 5-HT level and plasma SAS of patients with.OSAHS score (r=0.689, P=0.000); the positive tension and POMS scores in anxiety, depression and depression scores were positively correlated (r=0.522, P=0.000; r=0.548, P=0.000), and live There was a negative correlation between the force and movement score (r=-0.508, P=0.000). Conclusion OSAHS patients can present different negative emotions, with the increase of plasma 5-HT level, and the change of anxiety in OSAHS patients is related to the level of 5-HT change.

【作者單位】： 河北聯(lián)合大學(xué)護理康復(fù)學(xué)院;河北聯(lián)合大學(xué)附屬醫(yī)院;
【基金】：河北省科學(xué)技術(shù)研究與發(fā)展計劃項目(09276103D-11)
【分類號】：R563.8

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本文編號：1648509