發(fā)布時(shí)間：2018-03-09 13:11

  本文選題：痰熱清注射液　切入點(diǎn)：心力衰竭　出處：《中華醫(yī)院感染學(xué)雜志》2017年22期 　論文類型：期刊論文

【摘要】：目的探討痰熱清注射液對心力衰竭伴肺部感染患者血清膽堿酯酶及免疫功能的影響。方法選取2013年3月-2015年8月醫(yī)院符合標(biāo)準(zhǔn)的心力衰竭伴肺部感染患者90例,按隨機(jī)數(shù)字表法分為2組,每組45例,對照組患者采用頭孢哌酮/舒巴坦治療,研究組在此基礎(chǔ)上采用痰熱清注射液治療,持續(xù)1周,治療前和治療1周后采肘靜脈血測定T淋巴細(xì)胞亞群(CD_8~+、CD_4~+/CD_8~+)、免疫球蛋白(IgG、IgM)和CHE、BNP、NT-proBNP等,測定心功能指標(biāo),同時(shí)比較臨床療效及不良反應(yīng)。結(jié)果對照組總有效率為77.78%低于研究組的93.33%,差異有統(tǒng)計(jì)學(xué)意義(P0.05);與治療前比較,兩組治療1周后T淋巴細(xì)胞亞群(CD_8~+、CD_4~+/CD_8~+)和免疫球蛋白(IgG、IgM)升高,CHE升高,BNP、NT-proBNP降低,LAD、LVEDD、LVESD降低,LVEF升高(P0.05);與對照組比較,研究組治療1周后T淋巴細(xì)胞亞群(CD_8~+、CD_4~+/CD_8~+)和免疫球蛋白(IgG、IgM)較高,CHE較高,BNP、NT-proBNP較低,CHE較高,LAD、LVEDD、LVESD較低,LVEF較高(P0.05);兩組不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義。結(jié)論痰熱清注射液治療心力衰竭伴肺部感染,有利于提高免疫功能和心功能,降低心肌損傷,且對肝/腎無影響,可作為臨床治療方案推廣。
[Abstract]:Objective to investigate the effect of Tanreqing injection on serum cholinesterase and immune function in patients with heart failure and pulmonary infection. The patients in the control group were treated with cefoperazone / sulbactam, and the study group was treated with Tanreqing injection for 1 week. Before and one week after treatment, T lymphocyte subsets were measured by T lymphocyte subsets and CD8 / CD8 / CD8, IgG / IgM and CHEBNPNT-proBNP, respectively. Cardiac function was measured. Results the total effective rate of the control group was 77.78% lower than that of the study group 93.33 (P 0.05). After one week of treatment, the T lymphocyte subsets CD8 / CD8 and IgG / IgM were increased, and BNPNT-proBNP decreased, LVEDDLVESD decreased LVEF and LVEF increased P0.05 compared with the control group, After one week of treatment, the T lymphocyte subsets in the study group were higher than those in the study group. The incidence of adverse reactions in the two groups was higher, the incidence of adverse reactions was higher, the incidence of adverse reactions was higher, the incidence of adverse reactions in the two groups was higher, the incidence of adverse reactions in the two groups was higher than that in the patients with higher BNPE, higher NT-proBNP, higher che, lower LVEDDD, LVESD, and higher LVEF, and the incidence of adverse reactions was higher in the study group than in the control group, and the incidence of adverse reactions was higher in the two groups. Conclusion Tanreqing injection in the treatment of heart failure with pulmonary infection is beneficial to improve immune function and cardiac function, reduce myocardial injury, and have no effect on liver / kidney.
【作者單位】： 江蘇省連云港市東�？h人民醫(yī)院心血管內(nèi)科;江蘇省連云港市東�？h人民醫(yī)院護(hù)理部;江蘇省連云港市東�？h人民醫(yī)院藥劑科;
【基金】：江蘇省衛(wèi)生廳科研基金資助項(xiàng)目(P201520)
【分類號(hào)】：R541.6;R563.1

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