本文選題：C-反應(yīng)蛋白　切入點：白介素-6　出處：《蘇州大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：通過檢測慢性阻塞性肺疾病(COPD)病人血清C-反應(yīng)蛋白（CRP）、白介素-6(IL-6)和白介素-10(IL-10)的水平，，探討其與COPD的相關(guān)性。 方法：選擇2013年09月～2014年02月期間在我院呼吸內(nèi)科住院治療的48例COPD急性加重期病人作為COPD急性加重期組，48例門診隨訪的COPD穩(wěn)定期病人作為COPD穩(wěn)定期組，選擇48例健康者作為健康對照組。各組研究對象的年齡、性別以及病程等因素之間比較，差異均不顯著，無統(tǒng)計學(xué)意義（P＞0.05），具有可比性。收集與處理三組研究對象的血液標(biāo)本，對各組研究對象的血清CRP、IL-6和IL-10的水平進(jìn)行檢測，并采用肺功能儀檢測研究對象的肺功能。比較各組研究對象的血清CRP、IL-6和IL-10的水平以及肺功能，并分析血清CRP、IL-6和IL-10的水平與肺功能之間的相關(guān)性。所得數(shù)據(jù)采用SPSS13.0統(tǒng)計軟件包進(jìn)行統(tǒng)計分析。 結(jié)果：（1）COPD急性加重期組、COPD穩(wěn)定期組、健康對照組的血清CRP水平兩兩之間比較差異顯著，具有統(tǒng)計學(xué)意義（P＜0.05）；COPD急性加重期組、COPD穩(wěn)定期組的血清IL-6水平與健康對照組比較差異顯著，具有統(tǒng)計學(xué)意義（P＜0.05），而COPD急性加重期組、COPD穩(wěn)定期組之間差異不顯著，無統(tǒng)計學(xué)意義（P＞0.05）；COPD急性加重期組、COPD穩(wěn)定期組的血清IL-10水平與健康對照組比較差異顯著，具有統(tǒng)計學(xué)意義（P＜0.05），而COPD急性加重期組、COPD穩(wěn)定期組之間差異不顯著，無統(tǒng)計學(xué)意義（P＞0.05）。（2）COPD急性加重期組、COPD穩(wěn)定期組、健康對照組的FEV1%和FEV1/FVC兩兩比較差異顯著，具有統(tǒng)計學(xué)意義（P＜0.05）。（3）COPD穩(wěn)定期組與急性加重期組患者血清CRP、IL-6、IL-10水平分別與FEV1%、FEV1/FVC顯著相關(guān)。 結(jié)論：（1）COPD急性加重期組、COPD穩(wěn)定期組、健康對照組研究對象的血清CRP、IL-6水平依次降低，而IL-10水平依次升高，它們參與了COPD疾病的炎癥反應(yīng)，測定血清中三者的變化對病情分析具有一定臨床價值。（2）CRP、IL-6水平與FEV1%、FEV1/FVC指標(biāo)負(fù)相關(guān)；IL-10水平與FEV1%、FEV1/FVC指標(biāo)正相關(guān)。血清CRP、IL-6、IL-10水平可作為評估COPD病情嚴(yán)重程度的觀察指標(biāo)。
[Abstract]:Aim: to investigate the correlation between serum C-reactive protein (COPD) and interleukin-6 (IL-6) and interleukin-10IL-10 (IL-10) in patients with chronic obstructive pulmonary disease (COPD). Methods: from September 2013 to February 2014, 48 patients with acute exacerbation of COPD who were hospitalized in Department of Respiratory Medicine in our hospital were selected as COPD acute exacerbation group and 48 outpatient follow-up COPD stable patients as COPD stable group. 48 healthy subjects were selected as the healthy control group. There were no significant differences in age, sex and course of disease among the study subjects, and there was no statistical significance (P > 0.05). The blood samples of the three groups were collected and treated. The levels of serum CRPP-IL-6 and IL-10 were measured in each group, and lung function was measured by pulmonary function analyzer. The levels of serum CRPP-IL-6 and IL-10 and pulmonary function were compared. The correlation between the levels of IL-6 and IL-10 in serum and lung function was analyzed. The data were statistically analyzed by SPSS13.0 software package. Results there was a significant difference in serum CRP levels between the stable phase group and the healthy control group (P < 0.05). The serum IL-6 level in the stable phase group was significantly higher than that in the healthy control group (P < 0.05). There was no significant difference in serum IL-10 level between COPD acute exacerbation group and healthy control group (P > 0.05), but there was no significant difference between stable COPD group and COPD acute exacerbation group (P > 0.05). There was no significant difference between stable COPD group and COPD acute exacerbation group (P > 0.05). The difference between FEV1% and FEV1/FVC in healthy control group was significant. The serum levels of IL-6 and IL-10 in stable COPD group and acute exacerbation group were significantly correlated with FEV1 / FVC, respectively. Conclusion the serum levels of CRP- IL-6 in patients with acute exacerbation of IL-10 were decreased in turn, while the levels of IL-10 were increased in turn. They were involved in the inflammatory reaction of COPD disease. The determination of the three levels in serum was of certain clinical value for the analysis of the disease. The level of IL-6 was negatively correlated with the FEV1 / FVC index and the level of IL-10 was positively correlated with the FEV1 / FVC index. The level of serum CRPIL-6 / IL-10 could be used as an index to evaluate the severity of COPD.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R563.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙雪峰;王紅陽;楊萬杰;;COPD患者血細(xì)胞因子水平與肺功能的相關(guān)性分析[J];安徽醫(yī)學(xué);2010年06期

2 張志孟;劉海波;張光磊;鄭理玲;;吸入NO對嬰幼兒體外循環(huán)中氧自由基的影響及意義(附15例分析)[J];福建醫(yī)藥雜志;2010年01期

3 張德忠;溫建艷;季偉鋒;范麗民;;類風(fēng)濕性關(guān)節(jié)炎患者IL-6、IL-18和CRP的水平變化及意義[J];放射免疫學(xué)雜志;2009年02期

4 張建全;鐘小寧;柳廣南;李超乾;;白細(xì)胞介素-10在慢性阻塞性肺疾病中作用探討[J];廣西醫(yī)科大學(xué)學(xué)報;2008年01期

5 李睿;IL-10與樹突狀細(xì)胞的免疫調(diào)控作用[J];國外醫(yī)學(xué)(免疫學(xué)分冊);2004年03期

6 丁續(xù)紅;吳小軍;余昌平;胡蘇萍;;慢性阻塞性肺病急性加重期C反應(yīng)蛋白測定的臨床價值[J];武漢大學(xué)學(xué)報(醫(yī)學(xué)版);2006年05期

7 梁克山;譚蘭;;C反應(yīng)蛋白與動脈粥樣硬化性疾病[J];山東醫(yī)學(xué)高等專科學(xué)校學(xué)報;2006年02期

8 程玉武;;COPD患者血清IL-6、IL-8、TNF-α水平的檢測及意義[J];山東醫(yī)藥;2010年27期

9 何智輝;陳平;;慢性阻塞性肺疾病患者體內(nèi)白介素-6和C反應(yīng)蛋白質(zhì)量濃度的變化及意義[J];中國實用內(nèi)科雜志;2006年13期

10 高風(fēng)英;王星海;伏春明;陳國平;金文強(qiáng);朱麗華;柳金Z

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