本文關(guān)鍵詞： 涂陽肺結(jié)核 抗結(jié)核藥物 治療 不良反應(yīng) 影響因素　出處：《中國人獸共患病學(xué)報》2016年12期 　論文類型：期刊論文

【摘要】：目的探討涂陽肺結(jié)核患者接受抗結(jié)核藥物治療的不良反應(yīng)發(fā)生情況及其影響因素,為制定結(jié)核病防治策略提供參考。方法選擇2008—2010年我國8個省(市、自治區(qū))結(jié)核病定點醫(yī)療機構(gòu)治療診治的涂陽肺結(jié)核患者共2 142例,根據(jù)是否發(fā)生不良反應(yīng)將其分為兩組,運用卡方檢驗單因素及l(fā)ogistic多因素回歸對不良反應(yīng)發(fā)生的危險因素進(jìn)行分析。結(jié)果2 142例涂陽肺結(jié)核患者中536例患者出現(xiàn)不良反應(yīng),不良反應(yīng)發(fā)生率為25.0%。經(jīng)單因素分析結(jié)果表明年齡(χ2=23.815,P0.001)、吸煙情況(χ2=12.040,P=0.024)及結(jié)果差異均有統(tǒng)計學(xué)意義。多因素非條件logistic回歸結(jié)果顯示,45~64歲和≥65歲年齡組及吸煙是不良反應(yīng)發(fā)生的獨立危險因素,OR(95%CI)值分別為1.524(1.159~2.422)和1.756(1.200~2.570)及1.620(1.194~2.198)。結(jié)論涂陽肺結(jié)核患者中吸煙及中老年人是發(fā)生不良反應(yīng)的危險因素,在患者診治過程中,應(yīng)及時對這類高危人群進(jìn)行監(jiān)測和主動干預(yù),對發(fā)現(xiàn)和降低不良反應(yīng)的發(fā)生率有著重要意義。
[Abstract]:Objective to investigate the incidence of adverse reactions of smear positive pulmonary tuberculosis patients receiving anti-tuberculosis drug therapy and its influencing factors, and to provide a reference for the formulation of tuberculosis prevention and control strategies. Methods eight provinces (cities) were selected from 2008 to 2010 in China. A total of 2,142 smear positive pulmonary tuberculosis patients were treated by designated medical institutions in the autonomous region. They were divided into two groups according to whether or not adverse reactions occurred. The risk factors of adverse reactions were analyzed by chi-square test single factor and logistic multivariate regression. Results 536 of 2142 smear positive pulmonary tuberculosis patients had adverse reactions. The incidence of adverse reactions was 25.0.The results of univariate analysis showed that age (蠂 ~ 2o 23.815), smoking status (蠂 ~ 2 + 12.040 P ~ (0.024)) and the difference of the results were statistically significant. Multivariate non-conditional logistic regression analysis showed that the age group of 4564 years old and 鈮，

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