本文關(guān)鍵詞： 維生素D 阿奇霉素 型糖尿病 肺炎 白細(xì)胞介素 C反應(yīng)蛋白 免疫球蛋白G　出處：《中國(guó)藥房》2017年32期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討維生素D聯(lián)合阿奇霉素治療2型糖尿病患者肺炎的臨床療效和安全性,及其對(duì)血清炎癥指標(biāo)的影響。方法:選取我院2014年5月-2015年9月收治的2型糖尿病伴肺炎患者68例,按照隨機(jī)數(shù)字表法將患者分為對(duì)照組和試驗(yàn)組,各34例。兩組患者均給予胰島素強(qiáng)化降糖。對(duì)照組患者給予注射用阿奇霉素10 mg/kg+0.9%氯化鈉注射液500 m L,ivgtt,qd,連續(xù)應(yīng)用5 d后改用阿奇霉素干混懸劑10 mg/kg,po,qd,連用3 d后停藥4 d為1個(gè)療程,給藥2個(gè)療程;試驗(yàn)組患者在對(duì)照組基礎(chǔ)上給予維生素D滴劑800單位,po,qd,連續(xù)給藥4周。觀察兩組患者的臨床療效、治療前后的血清炎癥指標(biāo)[白細(xì)胞介素6(IL-6)、C反應(yīng)蛋白(CRP)和免疫球蛋白G(Ig G)]水平,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:試驗(yàn)組患者臨床總有效率(91.18%)顯著高于對(duì)照組(70.59%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患者IL-6、CRP和Ig G等血清炎癥指標(biāo)比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者IL-6和CRP均顯著降低,且試驗(yàn)組顯著低于對(duì)照組;兩組患者Ig G顯著升高,且試驗(yàn)組顯著高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:維生素D聯(lián)合阿奇霉素治療2型糖尿病患者肺炎的臨床效果顯著,有助于改善其血清IL-6、CRP和Ig G等炎癥因子水平,且安全性較高。
[Abstract]:Objective: to investigate the clinical efficacy and safety of vitamin D combined with azithromycin in the treatment of pneumonia in patients with type 2 diabetes mellitus. Methods: from May 2014 to September 2015, 68 patients with type 2 diabetes mellitus with pneumonia were divided into control group and experimental group. The control group was given azithromycin 10 mg/kg 0.9% sodium chloride injection 500ml / L iv iv GTT QD for 5 days and the control group received azithromycin dry suspension 10 mg / kg popoqd for 3 days after continuous use of azithromycin 10 mg / kg poxaqd. the patients in the control group were given azithromycin 10 mg/kg 0.9% sodium chloride injection iv iv GTT QD for 5 days. 4 days was a course of treatment. The patients in the test group were treated with 800 units of vitamin D drops for 4 weeks. The clinical efficacy of the two groups was observed. Before and after treatment, the levels of serum inflammatory markers [Interleukin-6, IL-6, C-Reactive protein (CRP) and immunoglobulin G (IGG)], Results: the total effective rate of the patients in the trial group was significantly higher than that in the control group (70.59g), and the difference was statistically significant (P 0.05). Before treatment, serum inflammatory indexes such as IL-6 CRP and IgG were compared between the two groups. After treatment, the IL-6 and CRP of the two groups were significantly lower than those of the control group, and that of the two groups were significantly higher than that of the control group, and that of the two groups was significantly higher than that of the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: the clinical effect of vitamin D combined with azithromycin on patients with type 2 diabetes mellitus pneumonia is significant. It is helpful to improve the levels of inflammatory cytokines such as IL-6, CRP and IgG, and the safety is higher.
【作者單位】： 唐山市協(xié)和醫(yī)院老年病科;
【基金】：唐山市科技計(jì)劃項(xiàng)目(No.121302126a)
【分類(lèi)號(hào)】：R563.1;R587.1
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本文編號(hào)：1507117