本文關(guān)鍵詞： 慢性阻塞性肺疾病 IgE 糖皮質(zhì)激素　出處：《中國(guó)老年學(xué)雜志》2014年11期 　論文類型：期刊論文

【摘要】：目的探討慢性阻塞性肺疾病急性加重(AECOPD)患者吸入性糖皮質(zhì)激素療效與血IgE水平的關(guān)系。方法將176例AECOPD病例隨機(jī)分為兩組,均予常規(guī)抗生素、吸氧治療,激素吸入組在此基礎(chǔ)上增加吸入布地奈德2 mg,2次/d,治療1 w,治療前后行肺功能、血?dú)夥治鰴z查并比較兩組的血IgE水平;此外,激素吸入組在治療前按疾病程度分為Ⅰ級(jí)(27例)、Ⅱ級(jí)(31例)、Ⅲ級(jí)(30例)。將AECOPD組患者按照臨床及動(dòng)脈血?dú)夥治鲋笜?biāo)分為改善組54例及無(wú)明顯緩解組34例,比較不同分級(jí)及預(yù)后患者的血IgE水平。結(jié)果治療前兩組的血IgE水平差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),治療前后兩組內(nèi)部比較IgE值均降低(均P0.01),治療后吸入組的血IgE水平低于常規(guī)治療組(t=9.933,P0.01);三組治療前的血IgE水平比較差異無(wú)統(tǒng)計(jì)學(xué)意義(F=0.285,P=0.792),治療后三組的血IgE水平下降(P0.01),三組治療前后差值比較差異無(wú)統(tǒng)計(jì)學(xué)意義(F=0.145,P0.05);吸入組患者治療后癥狀改善組血IgE水平低于無(wú)明顯改善組(t=19.795,P0.01)。結(jié)論 AECOPD患者血IgE水平升高,吸入糖皮質(zhì)激素可緩解臨床癥狀及改善肺功能,降低血IgE水平,但血IgE水平的高低與AECOPD病情的嚴(yán)重程度不成正比。
[Abstract]:Objective to investigate the relationship between the effect of inhaled glucocorticoid and the level of serum IgE in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 176 cases of AECOPD were randomly divided into two groups. On this basis, the hormone inhaled group increased the inhaled budesonide 2 mg / d for 1 week. Lung function, blood gas analysis and blood gas analysis were performed before and after treatment. In addition, blood IgE levels were compared between the two groups. According to the degree of disease, the hormone inhalation group was divided into three groups according to the degree of disease: 27 cases of grade 鈪，

本文編號(hào)：1503838