本文關(guān)鍵詞： 分化生長因子- C-反應(yīng)蛋白 急性惡化期 COPD 臨床診斷　出處：《實(shí)用醫(yī)學(xué)雜志》2017年15期 　論文類型：期刊論文

【摘要】：目的探討血漿中生長分化因子-15(GDF-15)在慢性阻塞性肺疾病(COPD)中穩(wěn)定期和急性惡化期的濃度及其在診斷穩(wěn)定期和急性惡化期的臨床應(yīng)用價值。方法回顧性分析2015-2016年我院診斷的COPD患者58例,其中COPD穩(wěn)定期和急性惡化期各29例,并選取同期在我院門診就診年齡、性別、體質(zhì)指數(shù)相匹配的健康體檢者29例為對照組。對比分析各組血漿中GDF-15、C-反應(yīng)蛋白(CRP)濃度。采用Spearman相關(guān)分析研究COPD穩(wěn)定期和急性惡化期GDF-15和CRP間的相關(guān)性,并比較GDF-15和CRP在區(qū)分COPD急性惡化期和穩(wěn)定期的診斷效能。結(jié)果 COPD穩(wěn)定期患者血漿中GDF-15濃度較對照組顯著增加,COPD急性惡化期較穩(wěn)定期GDF-15濃度顯著增加。COPD穩(wěn)定期患者中,GDF-15和CRP濃度呈正相關(guān)(r=0.776,P0.001),COPD急性惡化期,GDF-15和CRP濃度呈正相關(guān)(r=0.877,P0.001)。GDF-15對COPD急性惡化期診斷AUC為0.783(95%CI:0.666~0.900,P0.001),診斷準(zhǔn)確率為69%。CRP對COPD急性惡化期診斷AUC為0.686(95%CI:0.549~0.823,P0.01),診斷準(zhǔn)確率為59%。結(jié)論 COPD患者血漿中GDF-15濃度較健康的對照人群顯著增加,在穩(wěn)定期和急性惡化期COPD患者中,血漿中GDF-15和CRP均具有高度的相關(guān)性,GDF-15在診斷COPD患者穩(wěn)定期和急性惡化期的準(zhǔn)確率較CRP更高。
[Abstract]:Objective to investigate the plasma levels of growth differentiation factor-15 GDF-15 in the stable and acute stage of chronic obstructive pulmonary disease (COPDD) and its clinical value in the diagnosis of stable and acute exacerbation. Methods the clinical application of GDF-15 in patients with chronic obstructive pulmonary disease (COPD) from 2015 to 2016 was analyzed retrospectively. 58 cases of COPD were diagnosed, There were 29 cases of COPD in stable stage and 29 cases in acute exacerbation stage, and the age and sex of outpatient visit in our hospital were selected. The plasma GDF-15 C-reactive protein (CRP) concentrations in 29 healthy subjects matched with body mass index (BMI) were compared and analyzed. The correlation between GDF-15 and CRP in stable and acute stage of COPD was studied by Spearman correlation analysis. The diagnostic efficacy of GDF-15 and CRP in differentiating COPD from stable phase was compared. Results compared with control group, the plasma GDF-15 concentration in COPD stable phase was significantly higher than that in control group. There was a positive correlation between GDF-15 and CRP concentrations in patients with acute exacerbation of COPD. GDF-15 and CRP concentrations were positively correlated with the concentrations of GDF-15 and CRP in acute exacerbation of COPD. GDF-15 was 0.78395% 0.6660.900P0.001for the diagnosis of COPD in acute exacerbation, and the diagnostic accuracy was 69.CRP for AUC in acute exacerbation of COPD (0.68695CI: 0.5490.823p 0.01), and the diagnostic accuracy was 599.Conclusion the diagnostic accuracy of COPD is 593.Conclusion the diagnostic accuracy of GDF-15 is 0.68695CI0.5490.823P0.01. conclusion the diagnostic accuracy of COPD is 593.Conclusion the diagnostic accuracy of GDF-15 is 0.68695%. The concentration of GDF-15 in plasma was significantly higher than that in healthy controls. There was a high correlation between plasma GDF-15 and CRP in stable and acute exacerbation COPD patients. GDF-15 was more accurate than CRP in the diagnosis of stable and acute exacerbation of COPD.
【作者單位】： 武漢市醫(yī)療救治中心外一科;
【分類號】：R563.9

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