發(fā)布時間：2018-02-03 06:00

  本文關(guān)鍵詞： SAA 急性肺栓塞 危險分層　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的:血清淀粉樣蛋白 A(serum amyloidA,SAA)與 C-反應(yīng)蛋白(C-reactive protein,CRP)相似,同樣是一種十分重要的炎癥指標(biāo)。但CRP有助于急性肺栓塞的診斷和危險分層,而SAA與急性肺栓塞之間的關(guān)系卻不明確。本文研究的目的正是要探討SAA與急性肺栓塞之間存在的關(guān)系。研究方法:本研究回顧性收集了 2012年4月至2015年7月在浙江大學(xué)醫(yī)學(xué)院附屬邵逸夫醫(yī)院住院診治期間的71例急性肺栓塞患者和27例健康對照患者的臨床資料,包括 SAA、CRP、D-二聚體和 B 型利鈉肽(B-type natriuretic peptide,BNP)的血清濃度,以及由心超測出的左室射血分?jǐn)?shù)(Left ventricular ejection fraction,LVEF)和肺動脈收縮壓(systolic pulmonary artery pressure,PASP),并對急性肺栓塞和對照組中的SAA水平以及SAA、D-二聚體、CRP、BNP、LVEF、PASP間的相關(guān)性進行分析。研究結(jié)果:SAA在急性肺栓塞患者組中的濃度顯著高于健康對照組患者,而SAA水平增高的程度則與急性肺栓塞的嚴(yán)重程度相關(guān)。PASP水平與SAA呈正相關(guān)(r=0.330,p0.05),而 LVEF 水平則與 SAA 呈負相關(guān)(r=-0.267,p0.05)。結(jié)論:SAA有可能作為急性肺栓塞診斷、危險分層以及預(yù)后的一個依據(jù)。但是這仍然需要進一步的研究證實,同時SAA在急性肺栓塞機制中的作用也有待進一步地闡明。
[Abstract]:Objective: to study the similarity between serum amyloid A (SAA) and C-reactive protein (CRP). CRP is also a very important indicator of inflammation, but it is helpful in the diagnosis and risk stratification of acute pulmonary embolism. The relationship between SAA and acute pulmonary embolism is not clear. The purpose of this study is to explore the relationship between SAA and acute pulmonary embolism. From April 2012 to July 2015, the clinical data of 71 patients with acute pulmonary embolism and 27 healthy control patients who were hospitalized in run run Shaw Hospital, Zhejiang University Medical College. The serum concentrations of SAA, CRP, D-dimer and B-type natriuretic peptide, B-type natriuretic, were included. Left ventricular ejection fraction (left ventricular ejection fraction) was measured by echocardiography. LVEF) and systolic pulmonary artery pressure (PASP). The levels of SAA in acute pulmonary embolism and control group and SAA D- dimer were measured. The results showed that the concentration of PASP in patients with acute pulmonary embolism was significantly higher than that in healthy controls. However, the increase of SAA level was correlated with the severity of acute pulmonary embolism. PASP level was positively correlated with SAA (0.330% p 0.05). However, the level of LVEF was negatively correlated with SAA. Conclusion: LVEF may be used as a diagnosis of acute pulmonary embolism. A basis for risk stratification and prognosis, however, further research is needed, and the role of SAA in the mechanism of acute pulmonary embolism needs to be further clarified.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R563.5
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本文編號：1486629