系統(tǒng)性紅斑狼瘡患者頸動(dòng)脈內(nèi)中膜厚度與血清高敏CRP的關(guān)系
發(fā)布時(shí)間:2019-05-23 06:40
【摘要】:目的探討系統(tǒng)性紅斑狼瘡(SLE)患者頸動(dòng)脈內(nèi)中膜厚度(IMT)、外周血高敏C反應(yīng)蛋白(hs-CRP)的表達(dá)水平及兩者相關(guān)性。方法超聲檢查70例SLE女性患者(IMT≥1.0mm者12例為IMT陽(yáng)性組;IMT1.0mm者58例為IMT陰性組)及40例健康女性的頸動(dòng)脈IMT,并用ELISA測(cè)定其血清hs-CRP水平,分析兩者相關(guān)性。結(jié)果 (1)SLE組(包括IMT陽(yáng)性組及IMT陰性組)hs-CRP水平高于對(duì)照組(P0.05),IMT陽(yáng)性組hs-CRP水平高于IMT陰性組(P0.05);(2)SLE組IMT與病程及hs-CRP水平呈正相關(guān)(分別為r=0.743,P0.001及r=0.827,P0.001);(3)根據(jù)ROC曲線,當(dāng)hs-CRP在4.44mg/L時(shí)診斷指數(shù)最大(0.815),靈敏度和特異度分別為91.7%和89.8%。結(jié)論頸動(dòng)脈IMT聯(lián)合hs-CRP檢測(cè)可作為SLE患者早期動(dòng)脈粥樣硬化的一項(xiàng)預(yù)測(cè)方法。
[Abstract]:Objective to investigate the expression of Gao Min C-reactive protein (hs-CRP) in peripheral blood of patients with carotid intima-media thickness (IMT),) in patients with systemic lupus erythematosus (SLE). Methods the carotid IMT, of 70 female patients with SLE (IMT 鈮,
本文編號(hào):2483684
[Abstract]:Objective to investigate the expression of Gao Min C-reactive protein (hs-CRP) in peripheral blood of patients with carotid intima-media thickness (IMT),) in patients with systemic lupus erythematosus (SLE). Methods the carotid IMT, of 70 female patients with SLE (IMT 鈮,
本文編號(hào):2483684
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