【摘要】：目的：運(yùn)用MRI擴(kuò)散峰度成像(DKI)技術(shù)探討抑郁癥患者腦微觀結(jié)構(gòu)的變化特點(diǎn),從影像學(xué)的角度為抑郁癥的發(fā)病機(jī)制提供有價(jià)值的信息。方法：收集28例新醫(yī)大一附院臨床確診的抑郁癥患者及28例年齡、性別、族別和教育年限相匹配的健康對照者。在常規(guī)磁共振平掃的基礎(chǔ)上利用擴(kuò)散峰度掃描技術(shù)對受試者進(jìn)行腦部掃描,將感性興趣分別設(shè)置在雙側(cè)額上回、額中回、額下回、雙側(cè)顳葉腦白質(zhì)區(qū)、雙側(cè)枕葉腦白質(zhì)區(qū)、胼胝體膝部及壓部,測定各感興趣區(qū)平均峰度(MK)值、部分各向異性(FA)值及平均擴(kuò)散(MD)值。結(jié)果：病例組雙側(cè)顳葉FA值較對照組減低,兩組間差異有統(tǒng)計(jì)學(xué)意義(P0.05),病例組雙側(cè)額上回和雙側(cè)顳葉MK值較對照組減低,兩組間差異有統(tǒng)計(jì)學(xué)意義(P0.05)：病例組各腦區(qū)MD值與對照組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)；病例組雙側(cè)額上回、雙側(cè)額中回、雙側(cè)額下回、胼胝體膝部及壓部的FA值與對照組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)；病例組雙側(cè)額中回、雙側(cè)額下回、雙側(cè)枕葉、胼胝體膝部及壓部的MK值與對照組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：磁共振DKI技術(shù)反映了抑郁癥患者與情感有關(guān)的腦區(qū)可能存在細(xì)微結(jié)構(gòu)的改變,為抑郁癥發(fā)病機(jī)制的研究提供客觀的影像學(xué)依據(jù)。
[Abstract]:Aim: to explore the changes of brain microstructure in patients with depression by using MRI diffusion kurtography (DKI) technique, and to provide valuable information for the pathogenesis of depression from the perspective of imaging. Methods: twenty-eight patients with depression diagnosed clinically in the first affiliated Hospital of New Medical University and 28 healthy controls matched with age, sex, ethnicity and educational years were collected. On the basis of conventional magnetic resonance imaging, diffusion kurtosis scanning technique was used to scan the brain of the subjects. The perceptual interest was located in bilateral superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, bilateral temporal lobe white matter area and bilateral occipital lobe white matter area, respectively. The average kurtosis (MK), partial anisotropic (FA) and average diffused (MD) were measured in the geniculus and pressure of corpus callosum. Results: the FA value of bilateral temporal lobe in the case group was significantly lower than that in the control group (P0.05). The MK value of the bilateral superior frontal gyrus and bilateral temporal lobe in the case group was lower than that in the control group. The difference between the two groups was statistically significant (P0.05): there was no significant difference in MDvalues between the case group and the control group (P0.05); The FA values of bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral inferior frontal gyrus, knee and pressure of corpus callosum were not significantly different from those of the control group (P0.05). The MK values of bilateral middle frontal gyrus, bilateral inferior frontal gyrus, bilateral occipital lobe, geniculus and pressure of corpus callosum in the case group were not significantly different from those in the control group (P0.05). Conclusion: magnetic resonance imaging (DKI) may reflect the subtle structural changes in the brain regions associated with emotion in patients with depression, which provides objective imaging evidence for the study of the pathogenesis of depression.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.2

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