【摘要】：目的探討超聲射頻信號定量技術(shù)評價血脂異�；颊哳i總動脈內(nèi)-中膜厚度(IMT)和彈性改變及高密度脂蛋白膽固醇(HDL-C)對頸總動脈結(jié)構(gòu)和彈性功能的影響。資料與方法選取血脂異�；颊�150例作為高脂血癥組,分為高血脂伴HDL-C升高50例(A組)、高血脂而HDL-C正常50例(B組)、高血脂伴HDL-C降低50例(C組),同期選取體檢健康者50例作為對照組(D組)。應(yīng)用超聲射頻信號技術(shù)分析高脂血癥及HLD-C對頸總動脈IMT及彈性參數(shù)順應(yīng)性系數(shù)(CC)、僵硬度指數(shù)(β)、脈搏波傳導(dǎo)速度(PWV)、動脈反射波增強(qiáng)指數(shù)(AIx)的影響。結(jié)果 B組IMT、β、PWV、AIx較D組增高,CC降低,差異有統(tǒng)計學(xué)意義(t=5.141、4.219、4.898、4.142、-3.758,P0.05)。B組的IMT、β、PWV、AIx較A組升高,CC較A組降低,差異均有統(tǒng)計學(xué)意義(t=3.425、2.807、2.913、2.209、-2.091,P0.05、P0.01);C組的IMT、β、PWV、AIx較B組升高,CC較B組降低,差異均有統(tǒng)計學(xué)意義(t=4.937、2.195、3.337、2.067、-3.049,P0.05、P0.01));A組IMT、PWV較D組升高,差異均有統(tǒng)計學(xué)意義(t=2.236、2.407,P0.05),而CC、β、AIx與D組比較差異無統(tǒng)計學(xué)意義(t=-1.693、1.845、1.967,P0.05)。HDL-C升高可降低高血脂患者頸動脈IMT和僵硬度,升高彈性,反之頸動脈IMT和僵硬度增加,彈性下降。結(jié)論超聲射頻信號技術(shù)能夠自動、實(shí)時、準(zhǔn)確測量血脂異�；颊哳i總動脈IMT和動脈彈性,可為臨床評價動脈早期結(jié)構(gòu)和功能變化及調(diào)脂治療提供較為準(zhǔn)確的定量指標(biāo)。
[Abstract]:Objective to evaluate the changes of carotid intima-media thickness (IMT) and elasticity in patients with dyslipidemia and the effect of high density lipoprotein cholesterol (HDL-C) on the structure and elastic function of common carotid artery. Materials and methods 150 patients with dyslipidemia were divided into hyperlipidemia group (group A), hyperlipidemia with HDL-C elevation (group A), hyperlipidemia with normal HDL-C (group B), and hyperlipidemia with HDL-C decrease (group C). At the same time, 50 healthy subjects were selected as control group (group D). The effects of hyperlipidemia and HLD-C on (CC), stiffness index (尾) and pulse wave conduction velocity (PWV),) arterial reflection wave enhancement index (AIx) of common carotid artery (CCA), compliance coefficient (CC),) and pulse wave conduction velocity (PWV),) were analyzed by radio frequency ultrasound (RF) technique. Results the levels of IMT, 尾 and PWV,AIx in group B were significantly higher than those in group D (t = 5.141, 4.219, 4.898, 4.142, and 3.758, respectively). The levels of IMT, 尾 and PWV,AIx in group). B were higher than those in group A, while the level of CC in group). B was lower than that in group A. The differences were statistically significant (t = 3.425, 2.807, 2.913, 2.209, 2.091, P 0.05, P0.01); The levels of IMT, 尾 and PWV,AIx in group C were higher than those in group B, while the CC in group B were lower than those in group B (t = 4.937, 2.195, 3.337, 2.067, 3.049, P 0.05, P0.01);). IMT,PWV in group A was significantly higher than that in group D (t = 2.236, 2.407, P0.05), but there was no significant difference in CC, 尾 and AIx between group A and group D (t = 1.693, 1.845, 1.967, P < 0.05), but there was no significant difference between group A and group D (t = 1.693, 1.845,1.967). The increase of HDL-C could decrease the IMT and stiffness of carotid artery and increase the elasticity of patients with hyperlipidemia. On the other hand, the increase of IMT and stiffness of carotid artery decreased the elasticity of carotid artery. Conclusion Ultrasound radiofrequency signal technique can automatically, real-time and accurately measure the common carotid artery IMT and arterial elasticity in patients with dyslipidemia. It can provide a more accurate quantitative index for the clinical evaluation of the early changes of arterial structure and function and the treatment of lipid regulation.
【作者單位】： 廣東省人民醫(yī)院廣東省醫(yī)學(xué)科學(xué)院超聲科;
【基金】：廣東省企業(yè)技術(shù)研發(fā)與升級改造專項資金項目(2013B021800156)
【分類號】：R445.1;R589.2

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