【摘要】：目的：為與杏仁核形態(tài)改變的相關(guān)疾病提供線(xiàn)性測(cè)量指標(biāo)及功能評(píng)價(jià)指標(biāo)。 方法：自2013年6月-2013年12月招募健康志愿者，受檢者均行常規(guī)MRI平掃、3D T1掃描和DTI成像,選出符合納入標(biāo)準(zhǔn)的受檢者共188名，其中男性79例，女性109例，年齡20-75歲，平均年齡45.26±13.99歲，中位年齡46歲，并按性別、年齡分組。應(yīng)用三維體積分析軟件手工勾繪ROI，測(cè)量杏仁核的體積、厚度和橫徑，并進(jìn)行標(biāo)準(zhǔn)化計(jì)算。應(yīng)用Philips自帶DTI分析軟件Fiber Track/Interaction Mode/Track Single ROI Fibers，冠狀位勾畫(huà)ROI，軟件自動(dòng)生成杏仁核FA值、杏仁核ADC值及杏仁核纖維束數(shù)量、纖維束FA值、纖維束ADC值。采用t檢驗(yàn)和方差分析分別比較標(biāo)準(zhǔn)化前后性別、側(cè)別、年齡組間杏仁核體積、杏仁核FA值、杏仁核ADC值及杏仁核纖維束數(shù)量、纖維束FA值、纖維束ADC值的差異；采用直線(xiàn)回歸分別分析標(biāo)準(zhǔn)化前后杏仁核體積與杏仁核厚度、杏仁核橫徑的線(xiàn)性關(guān)系及杏仁核纖維束數(shù)量、纖維束FA值、纖維束ADC值與杏仁核體積的線(xiàn)性關(guān)系。 結(jié)果： 1標(biāo)準(zhǔn)化前兩側(cè)杏仁核體積、橫徑、厚度均存在性別間差異(P＜0.05)，男性大于女性；標(biāo)準(zhǔn)化后右側(cè)杏仁核體積及兩側(cè)杏仁核橫徑、厚度均存在性別間差異(P＜0.05)，但為女性大于男性，左側(cè)杏仁核體積無(wú)性別間差異(P＞0.05)。 2標(biāo)準(zhǔn)化前后杏仁核的體積、橫徑、厚度均存在側(cè)別差異(P＜0.02),左側(cè)大于右側(cè)。 3標(biāo)準(zhǔn)化前兩側(cè)杏仁核體積第2與第1、3、4、5年齡組間有差異(P＜0.05)，但標(biāo)準(zhǔn)化后年齡分組間沒(méi)有差異（P＞0.05）,杏仁核厚度、橫徑在標(biāo)準(zhǔn)化前后各年齡組間沒(méi)有差異(P＞0.05)。 4杏仁核體積與其橫徑呈線(xiàn)性正相關(guān)，，左側(cè)更顯著，右側(cè)相關(guān)系數(shù)標(biāo)準(zhǔn)化前后分別為r=0.299和0.297,決定系數(shù)R2=0.089和0.088，左側(cè)分別為r=0.344和0.374,決定系數(shù)R2=0.118和0.140。 5杏仁核體積與其厚度呈線(xiàn)性正相關(guān)，右側(cè)相關(guān)系數(shù)標(biāo)準(zhǔn)化前后分別為r=0.605和0.595,決定系數(shù)R2=0.366和0.354，左側(cè)分別為r=0.541和0.535,決定系數(shù)R2=0.293和0.286，R2值右側(cè)大于左側(cè)，說(shuō)明右側(cè)杏仁核的厚度對(duì)體積影響較大。 6左側(cè)杏仁核的纖維束數(shù)量存在性別差異(P=0.021),男性多于女性。尚不能認(rèn)為杏仁核FA值、杏仁核ADC值及右側(cè)杏仁核纖維束數(shù)量、纖維束FA值、纖維束ADC值存在性別差異(P＞0.05)。 7杏仁核FA值、杏仁核纖維束數(shù)量、纖維束FA值存在側(cè)別差異(P＜0.05)，均為左側(cè)大于右側(cè)。還不能認(rèn)為杏仁核ADC值、杏仁核纖維束ADC值存在側(cè)別差異(P＞0.05)。 8杏仁核FA值、杏仁核ADC值及杏仁核纖維束數(shù)量、纖維束FA值、纖維束ADC值在總體樣本各年齡組間差異沒(méi)有統(tǒng)計(jì)學(xué)意義。 9右側(cè)杏仁核纖維束數(shù)量與其體積呈線(xiàn)性正相關(guān)，相關(guān)系數(shù)r=0.151,決定系數(shù)R2=0.023，R2值遠(yuǎn)遠(yuǎn)小于0.3，說(shuō)明體積變化對(duì)纖維束數(shù)量的影響非常小，左側(cè)杏仁核纖維束數(shù)量、兩側(cè)杏仁核纖維束的FA值、ADC值與體積無(wú)明顯相關(guān)關(guān)系。 結(jié)論：高分辨力MRI能夠清晰顯示杏仁核形態(tài)及探測(cè)其生理狀態(tài)下的變化,可以準(zhǔn)確測(cè)量杏仁核體積,定量分析其功能狀態(tài)，為與杏仁核有關(guān)疾病的診斷和鑒別診斷提供科學(xué)依據(jù)。
[Abstract]:Objective: To provide linear measurement index and functional evaluation index for related diseases that change with the form of amygdala. Methods: A total of 188 healthy volunteers were recruited from June 2013 to December 2013. The subjects were treated with conventional MRI flat scan, 3D T1 scan and DTI imaging to select a total of 188 subjects, including 79 male, 109 female, 20-75 years old, average age of 45. 26 and 13.99. At the age of 46, the median age is 46 years and is divided by sex and age. The three-dimensional volume analysis software was applied to draw the ROI by hand, and the volume, thickness and transverse diameter of the amygdala were measured. Calculation. Application of Philips's DTI analysis software Fiber Track/ Direction Mode/ Track Single ROI Fibers, coronal contouring ROI, software automatically generated amygdala FA value, amygdala ADC value, and number of amygdala fiber bundles, fiber bundle FA value, fiber bundle ADC The results of t-test and variance analysis were used to compare the number of amygdala, amygdala and amygdala in the amygdala, the value of the amygdala, the number of the amygdala, the FA value of the fiber bundle, the difference of the value of the fiber bundle ADC. The linear correlation between the size of the amygdala and the amygdala, the transverse diameter of the amygdala, the number of the amygdala fiber bundles, the FA value of the fiber bundle, the value of the fiber bundle ADC and the volume of the amygdala were analyzed by linear regression. Department. Results: The size of the amygdala, the transverse diameter and the thickness of the amygdala in the first two sides were different (P <0.05), the male was larger than that of the female, the size of the amygdala on the right side and the transverse diameter of the amygdala on both sides were different (P <0.05), but it was the female. Sex is greater than that of male and left amygdala without sex (P> 0. 05). The volume, transverse diameter and thickness of the amygdaloid nucleus before and after normalization were different (P <0.02). There was no difference between group 2 and group 1, 3, 4 and 5 (P <0.05), but there was no difference (P> 0.05), amygdala thickness and transverse diameter before and after normalization. The volume of the amygdala was positively correlated with its transverse diameter, the left side was more significant, the correlation coefficient of the right side was r = 0.299 and 0.297, respectively, the coefficient of determination was r = 0.344 and 0.374, and the coefficient of determination of R2 = 0.374 and 0.374, respectively. The volume of amygdala of 0.118 and 0.140. 5 was positively correlated with its thickness, r = 0.605 and 0.595, r = 0.366 and 0.354, respectively. The left side was r = 0.541 and 0.535, and the coefficient of determination of R2 = 0.293 and 0.286, and the right of R2 was greater than that of the left. the thickness of the amygdala had a significant effect on the volume. There was a gender difference in the number of fiber bundles on the left amygdala. P = 0. 021), more men than women. The amygdala value, the amygdala value, and the right amygdala fiber bundle number, the fiber bundle FA value, the fiber bundle ADC, There was a gender difference in the value (P> 0.05). The value of the amygdaloid nucleus, the number of the amygdala fiber bundles and the value of the fiber bundle FA were different. (P <0.05), the left side is greater than the right. It is also not considered that the amygdala ADC value, the amygdala fiber bundle A There was no difference in the DC value (P> 0.05). The value of the amygdala, the ADC value of the amygdala and the number of the amygdala fiber bundles, the FA value of the fiber bundle, the value of the fiber bundle ADC There was no statistical difference between the total sample age groups. The number of the right amygdala fiber bundles was positively correlated with the volume, the correlation coefficient r = 0.151, the coefficient of determination R2 = 0.023, the R2 value was much less than 0.3, the effect of volume change on the number of the fiber bundles was very small, the left side Almond fiber bundle number, amygdala on both sides Conclusion: High-resolution MRI can clearly show the shape of the amygdala and the change of the physiological state of the amygdala, and can measure the volume of the amygdala accurately and quantitatively analyze its functional state.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R445.2

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