經(jīng)胰泌素刺激核磁共振成像評(píng)價(jià)胰腺外分泌功能的研究
發(fā)布時(shí)間：2018-12-13 18:00
【摘要】：目的：利用胰泌素刺激胰膽管成像(MRCP)技術(shù)和磁共振彌散加權(quán)成像(DWI)技術(shù)評(píng)價(jià)正常人胰腺外分泌功能。 方法：受試者為30名健康志愿者。所有健康志愿者均采用體外校準(zhǔn)器法進(jìn)行30分鐘掃描。MRCP檢查采用單次激發(fā)半傅里葉采集快速自旋回波序列(HASTE),DWI采用自旋回波-回波平面成像技術(shù)(EPI),彌散梯度b值分別為0,400s/mm2。注射胰泌素前掃描MRCP.T2冠狀位和DWI序列作為對(duì)照,然后加校準(zhǔn)器掃描一次MRCP序列作為蒙片。注射胰泌素后前1Omin以1min為間隔重復(fù)掃描MRCP及T2冠狀位。之后以2min為間隔掃描MRCP及T2冠狀位序列至第30分鐘。DWI序列在第10min開始,以5分鐘間隔掃描至第30min,胰泌素的注射量為8mcg。所得全部圖像通過磁共振后處理系統(tǒng)進(jìn)行收集及處理分析。計(jì)算各組數(shù)據(jù)的均值與標(biāo)準(zhǔn)差,對(duì)比注射胰泌素前后數(shù)據(jù)的變化,并進(jìn)行相關(guān)統(tǒng)計(jì)學(xué)分析。 結(jié)果：健康人群注射胰泌素后胰液可持續(xù)分泌。胰管在第(2.7±0.9)min擴(kuò)張并達(dá)到最大值后逐漸恢復(fù)到基礎(chǔ)值,對(duì)比注藥前胰管管徑與注藥后胰管最大徑,通過配對(duì)樣本T檢驗(yàn)胰頭、胰體及胰尾管徑P0.05,證實(shí)有統(tǒng)計(jì)學(xué)差異。胰液分泌峰值的時(shí)間為(24.9±4.4)min,最大分泌量為(91.2±43.2)ml,第一次最大分泌增量時(shí)間為(3.7±2.4)min,最大分泌增量為(12.7±5.1)ml,第二次最大分泌增量時(shí)間為(15.4±5.7)min,最大分泌增量為(14.5±10.2)ml。通過胰液-時(shí)間曲線可發(fā)現(xiàn)15min內(nèi)胰液的分泌量與注射胰泌素的時(shí)間呈直線回歸關(guān)系,經(jīng)相關(guān)性分析pearson檢驗(yàn)p0.01呈顯著相關(guān)。繪制30min內(nèi)胰泌素分泌量與時(shí)間的分泌趨勢發(fā)現(xiàn)二者可以用二次曲線回歸方程進(jìn)行擬合,并且在25.64min為轉(zhuǎn)折點(diǎn)開始呈下降趨勢。胰液在十二指腸充盈程度達(dá)到3級(jí)的時(shí)間為(10.8±2.4)min,10min后胰液逐步充盈十二指腸,空腸近段及中遠(yuǎn)端。注射藥前胰腺ADC值：(2.39±0.26)x10-3mm2/s2、注藥后：10min:(2.42±0.31)x10-3mm2/s2、15min:(2.38±0.25)x10-3mm2/s2、20min:(2.40±0.22)x10-3mm2/s2、25min:(2.44±0.18)x10-3mm2/s2、30min:(2.50±0.13) x10-3mm2/s2。通過配對(duì)樣本T檢驗(yàn).P0.05,注藥前后無統(tǒng)計(jì)學(xué)差異。注藥前胰腺與肝臟的比值rADC值：(1.15±0.13)x10-3mm2/s2,注藥后rADC:10min:(1.19±0.15) x10-3mm/s2、15min:(1.18±0.20)x10-3mm2/s2、20min:(1.17±0.88)x10-3mm2/s、25min:(1.14±0.10)x10-3mm2/s2、30min:(1.22±0.27)x10-3mm2/s2。通過配對(duì)樣本T檢驗(yàn)P0.05,注藥前后rADC值無統(tǒng)計(jì)學(xué)差異。 結(jié)論：胰泌素刺激胰膽管成像技術(shù)和彌散加權(quán)成像技術(shù)可以評(píng)價(jià)正常人胰腺外分泌功能；注射胰泌素后胰液會(huì)達(dá)到峰值后逐漸恢復(fù)到基礎(chǔ)狀態(tài)；注射胰泌素前后胰腺ADC值及rADC值無變化。
[Abstract]:Aim: to evaluate the exocrine function of normal pancreas by using pancreatic secretion stimulating cholangiopancreatography (MRCP) and magnetic resonance diffusion-weighted imaging (DWI). Methods: the subjects were 30 healthy volunteers. All healthy volunteers were scanned with an extracorporeal calibrator for 30 minutes. MRCP was performed with single excitation half Fourier transform acquisition of fast spin echo sequence (HASTE), DWI and spin echo plane imaging technique (EPI), The dispersion gradient b is 0 400 s / m 2. The MRCP.T2 coronal position and DWI sequence were compared before injection of pancreatic secretin, and then the MRCP sequence was scanned by a calibrator. MRCP and T 2 coronal scanning were performed on 1Omin with 1min interval before injection of pancreatic secretin. Then MRCP and T2 coronal sequence were scanned at 2min interval to 30 minutes. DWI sequence began at 10min and was scanned at 5 minutes interval to 30 min. The injection amount of secretin was 8mcg. All the images were collected and analyzed by magnetic resonance postprocessing system. The mean value and standard deviation of each group were calculated, and the changes of the data before and after injection of pancreatic secretin were compared, and the correlation statistical analysis was carried out. Results: pancreatic juice can be secreted continuously after injection of pancreatic secretin in healthy people. The pancreatic duct was gradually restored to its base value after (2. 7 鹵0. 9) min dilated and reached its maximum value. The diameter of pancreatic duct before and after injection was compared with the maximum diameter of pancreatic duct after injection. The diameter of pancreatic head, body and tail of pancreas was examined by paired sample T. Statistical differences were confirmed. The time of peak secretion of pancreatic juice is (24.9 鹵4.4) min, maximum secretion is (91.2 鹵43.2) ml, the first maximum secretion increment time is (3.7 鹵2.4) min, maximum secretion increment is (12.7 鹵5.1) ml,. The second maximum secretion increment time is (15.4 鹵5.7) min, the maximum secretion increment is (14.5 鹵10.2) ml.. It was found that the secretion of pancreatic juice in 15min had a linear regression relationship with the time of injection of pancreatic secretin, and the correlation analysis showed that there was a significant correlation between the secretion of pancreatic juice and the time of injection of pancreatic secretin by pearson test (p0.01). It was found that the secretory amount and time of pancreatic secretion in 30min could be fitted by quadratic regression equation, and that they had a decreasing trend at the turning point of 25.64min. The time of pancreatic juice filling in the duodenum was (10.8 鹵2.4) min,10min. The pancreatic juice gradually filled the duodenum, proximal jejunum and middle and distal part of the jejunum. ADC of pancreas before injection: (2.39 鹵0.26) x 10-3 mm 2 / s 2, 10 min: (2.42 鹵0.31) x 10-3 mm 2 / s 2 15 min: (2.38 鹵0.25) x 10 -3 mm 2 / s 2 min 20 min: (2.40 鹵0.22) x 10 -3 mm 2 / s 225 min: (2.44 鹵0.18) x 10 -3 mm 2 / s 230min: (2.50 鹵0.13) x 10 -3 mm 2 / s 2 / 2. There was no statistical difference before and after injection of P0.05 by T test of paired samples. The ratio of pancreas to liver rADC before injection was (1.15 鹵0.13) x 10-3 mm 2 / s 2, and after injection rADC:10min: was (1.19 鹵0.15) x 10 -3 mm 路s 2 min: (1.18 鹵0.20) x 10 -3 mm 2 / s 2 min: (1.17 鹵0.88) x 10 -3 mm 2 路s 2 路s, 25 min: (1.14 鹵0.10) x 10-3 mm 2 / s 230 min: (1.22 鹵0.27) x 10 -3 mm 2 / s 2. There was no significant difference in rADC before and after injection by paired T test (P 0.05). Conclusion: pancreatic secretin stimulating cholangiopancreatography and diffusion-weighted imaging can evaluate the exocrine function of normal pancreas, and the pancreatic juice will gradually recover to the basic state after the injection of pancreatic secretin. There was no change in pancreatic ADC and rADC values before and after injection of pancreatic secretin.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.2
本文編號(hào)：2376975
[Abstract]:Aim: to evaluate the exocrine function of normal pancreas by using pancreatic secretion stimulating cholangiopancreatography (MRCP) and magnetic resonance diffusion-weighted imaging (DWI). Methods: the subjects were 30 healthy volunteers. All healthy volunteers were scanned with an extracorporeal calibrator for 30 minutes. MRCP was performed with single excitation half Fourier transform acquisition of fast spin echo sequence (HASTE), DWI and spin echo plane imaging technique (EPI), The dispersion gradient b is 0 400 s / m 2. The MRCP.T2 coronal position and DWI sequence were compared before injection of pancreatic secretin, and then the MRCP sequence was scanned by a calibrator. MRCP and T 2 coronal scanning were performed on 1Omin with 1min interval before injection of pancreatic secretin. Then MRCP and T2 coronal sequence were scanned at 2min interval to 30 minutes. DWI sequence began at 10min and was scanned at 5 minutes interval to 30 min. The injection amount of secretin was 8mcg. All the images were collected and analyzed by magnetic resonance postprocessing system. The mean value and standard deviation of each group were calculated, and the changes of the data before and after injection of pancreatic secretin were compared, and the correlation statistical analysis was carried out. Results: pancreatic juice can be secreted continuously after injection of pancreatic secretin in healthy people. The pancreatic duct was gradually restored to its base value after (2. 7 鹵0. 9) min dilated and reached its maximum value. The diameter of pancreatic duct before and after injection was compared with the maximum diameter of pancreatic duct after injection. The diameter of pancreatic head, body and tail of pancreas was examined by paired sample T. Statistical differences were confirmed. The time of peak secretion of pancreatic juice is (24.9 鹵4.4) min, maximum secretion is (91.2 鹵43.2) ml, the first maximum secretion increment time is (3.7 鹵2.4) min, maximum secretion increment is (12.7 鹵5.1) ml,. The second maximum secretion increment time is (15.4 鹵5.7) min, the maximum secretion increment is (14.5 鹵10.2) ml.. It was found that the secretion of pancreatic juice in 15min had a linear regression relationship with the time of injection of pancreatic secretin, and the correlation analysis showed that there was a significant correlation between the secretion of pancreatic juice and the time of injection of pancreatic secretin by pearson test (p0.01). It was found that the secretory amount and time of pancreatic secretion in 30min could be fitted by quadratic regression equation, and that they had a decreasing trend at the turning point of 25.64min. The time of pancreatic juice filling in the duodenum was (10.8 鹵2.4) min,10min. The pancreatic juice gradually filled the duodenum, proximal jejunum and middle and distal part of the jejunum. ADC of pancreas before injection: (2.39 鹵0.26) x 10-3 mm 2 / s 2, 10 min: (2.42 鹵0.31) x 10-3 mm 2 / s 2 15 min: (2.38 鹵0.25) x 10 -3 mm 2 / s 2 min 20 min: (2.40 鹵0.22) x 10 -3 mm 2 / s 225 min: (2.44 鹵0.18) x 10 -3 mm 2 / s 230min: (2.50 鹵0.13) x 10 -3 mm 2 / s 2 / 2. There was no statistical difference before and after injection of P0.05 by T test of paired samples. The ratio of pancreas to liver rADC before injection was (1.15 鹵0.13) x 10-3 mm 2 / s 2, and after injection rADC:10min: was (1.19 鹵0.15) x 10 -3 mm 路s 2 min: (1.18 鹵0.20) x 10 -3 mm 2 / s 2 min: (1.17 鹵0.88) x 10 -3 mm 2 路s 2 路s, 25 min: (1.14 鹵0.10) x 10-3 mm 2 / s 230 min: (1.22 鹵0.27) x 10 -3 mm 2 / s 2. There was no significant difference in rADC before and after injection by paired T test (P 0.05). Conclusion: pancreatic secretin stimulating cholangiopancreatography and diffusion-weighted imaging can evaluate the exocrine function of normal pancreas, and the pancreatic juice will gradually recover to the basic state after the injection of pancreatic secretin. There was no change in pancreatic ADC and rADC values before and after injection of pancreatic secretin.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R445.2
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