【摘要】：研究不同注射速率對磁共振腦灌注測量值的影響,并探討最佳的注射速率。60名無明確腦血管疾病志愿者按對比劑注射流率(3、4、5 m L/s)分為3組,采取MR常規(guī)掃描及灌注掃描,將原始灌注掃描數(shù)據(jù)傳送到ADW4.3工作站,應(yīng)用GE專用灌注軟件處理得到相對腦血流量(r CBF)、相對腦血容量(r CBV)、對比劑平均通過時間(MTT)和達(dá)峰時間(TTP)函數(shù)圖,測量受試者各感興趣區(qū)(額葉白質(zhì)、丘腦及小腦)的r CBV、r CBF、MTT、TTP參數(shù)值。結(jié)果表明,60名無明確腦血管疾病志愿者均符合選入標(biāo)準(zhǔn),納入統(tǒng)計。不同流率組內(nèi)兩側(cè)額葉白質(zhì)、丘腦及小腦的r CBF、r CBV、MTT和TTP值左右對比,無明顯統(tǒng)計學(xué)差異(P0.05);不同流率組間兩側(cè)額葉白質(zhì)、丘腦及小腦各灌注參數(shù)比較顯示:組各感興趣區(qū)r CBF值,3 m L/s明顯低于4、5 m L/s組;各感興趣區(qū)r CBV值,3 m L/s組明顯低于4、5 m L/s組;各感興趣區(qū)MTT值,3 m L/s組較4、5 m L/s組明顯延遲;以上差異均具有顯著統(tǒng)計學(xué)差異(P0.05)。3、4、5 m L/s三組各感興趣區(qū)TTP值比較差異無統(tǒng)計學(xué)意義(P0.05);4 m L/s組與5 m L/s組,各感興趣區(qū)各參數(shù)值比較差異無統(tǒng)計學(xué)意義(P0.05)。使用4 m L/s的注射流率時,磁共振腦灌注成像能產(chǎn)生較好的團(tuán)注效果,可以滿足診斷要求,并可降低對比劑局部外滲甚至血管壁破裂的風(fēng)險;TTP值對注射流率影響腦灌注量的反應(yīng)程度不及r CBV、r CBF、MTT敏感。
[Abstract]:To study the effects of different injection rates on Mr perfusion measurements, and to explore the optimal injection rate, 60 volunteers with no definite cerebrovascular disease were divided into three groups according to the contrast medium injection rate (3? 4? 5 mL / s). The original perfusion scan data was transmitted to ADW4.3 workstation by MR routine scan and perfusion scan. The relative cerebral blood flow (r CBF),) relative cerebral blood volume (r CBV),) was obtained by GE software. The r CBV,r CBF,MTT,TTP parameters of the subjects' regions of interest (frontal white matter, thalamus and cerebellum) were measured by the mean time (MTT) and peak time (TTP) function. The results showed that 60 volunteers with no definite cerebrovascular disease met the selection criteria and were included in the statistics. There was no significant difference in r CBF,r CBV,MTT and TTP between the white matter of frontal lobe thalamus and cerebellum in different flow rate groups (P0.05). The comparison of perfusion parameters of white matter, thalamus and cerebellum between different flow rate groups showed that the r CBF value of 3 mL / s in each region of interest was significantly lower than that in 4 5 mL / s group. The value of r CBV in each region of interest was significantly lower in 3 mL / s group than that in 4 5 mL / s group, and the MTT value in 3 mL / s group was significantly delayed than that in 4 5 mL / s group. All the above differences were statistically significant (P0.05). There was no significant difference in TTP values among the three groups (P0.05). There was no significant difference between 4 mL / s group and 5 mL / s group in the parameters of each region of interest (P0.05). At the injection rate of 4 mL / s, magnetic resonance perfusion imaging can produce better mass injection effect, can meet the diagnostic requirements, and can reduce the risk of local extravasation of contrast agent and even vascular wall rupture. The response of TTP to the injection rate was less sensitive than that of r CBV,r CBF,MTT.
【作者單位】： 溫州醫(yī)科大學(xué)附屬第一醫(yī)院放射影像中心;溫州醫(yī)科大學(xué)數(shù)字化醫(yī)學(xué)研究所;
【基金】：溫州市科技局基金項目(Y20130011) 國家自然科學(xué)基金(81271663,31471146)
【分類號】：R445.2

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