【摘要】：目的 :研究星形細胞腫瘤術(shù)后瘤床區(qū)域的MRS改變。方法 :本研究包括手術(shù)組和對照組。均采用GE Signa VH/i 3.0T成像系統(tǒng)進行檢查,MRS采用多體素PRESS序列。手術(shù)組共18例,年齡9~67歲(平均46±14歲)。其中膠質(zhì)母細胞瘤(WHO4級)7例,間變性星形細胞瘤(WHO 3級)4例,彌漫性星形細胞瘤(WHO2級)6例,毛細胞型星形細胞瘤(WHO1級)1例。MRS測量兩個體素:腫瘤床區(qū)和對側(cè)正常區(qū)。對照組包括18例健康志愿者,體素位置選擇在右半卵圓中心區(qū)。結(jié)果 :星形細胞腫瘤術(shù)后腫瘤床區(qū)的MRS表現(xiàn)為NAA/Cr降低,Cho/Cr、Cho/NAA、Lip0.9/Cr及Lip1.3/Cr升高;而對側(cè)正常區(qū)只出現(xiàn)NAA/Cr的降低。結(jié)論 :MRS可以對星形細胞腫瘤術(shù)后的代謝物改變進行檢測,有利于今后對腫瘤治療后的反應(yīng)進行評估。
[Abstract]:Objective: to study the changes of MRS in the bed area of astrocytoma after operation. Methods: the study included operation group and control group. All patients were examined by GE Signa VH/i 3.0T imaging system and MRS by multivoxel PRESS sequence. There were 18 cases in the operation group, aged from 9 to 67 years (mean 46 鹵14 years). There were 7 cases of glioblastoma (grade WHO4), 4 cases of anaplastic astrocytoma (grade WHO 3) and 6 cases of diffuse astrocytoma (grade WHO2). One case of hairy cell astrocytoma (WHO1 grade). Two voxins were measured by MRS: tumor bed area and contralateral normal area. The control group consisted of 18 healthy volunteers, the position of voxel was located in the center of the right half oval. Results: the MRS in the bed area of astrocytoma was decreased, Cho/Cr,Cho/NAA,Lip0.9/Cr and Lip1.3/Cr were increased, but the decrease of NAA/Cr was observed in the contralateral normal area. Conclusion: MRS can detect the changes of metabolites after operation of astrocytoma, which is helpful to evaluate the reaction of astrocytoma after treatment.
【作者單位】： 復(fù)旦大學(xué)附屬華山醫(yī)院 上海伽瑪醫(yī)院放射科;復(fù)旦大學(xué)附屬婦產(chǎn)科醫(yī)院放射科;復(fù)旦大學(xué)附屬華山醫(yī)院神經(jīng)外科;上海伽瑪醫(yī)院放療科;
【基金】：上海市衛(wèi)生和計劃生育委員會科研課題資助項目(基金編號:20124203)~~
【分類號】：R739.41;R445.2

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