【摘要】：目的探討聯(lián)合應用氫質(zhì)子磁共振波譜(1H-MRS)相關(guān)代謝物和磁共振擴散加權(quán)成像(DWI)的表觀擴散系數(shù)(ADC)值在腦膠質(zhì)瘤分級診斷中的診斷價值。方法回顧性分析經(jīng)病理證實的59例腦膠質(zhì)瘤的MRS和DWI圖像。按照WHO 2007標準,將病例分為兩組:低級別膠質(zhì)瘤組(Ⅰ~Ⅱ級,24例)和高級別膠質(zhì)瘤組(Ⅲ~Ⅳ級,35例),測量并計算腫瘤實質(zhì)區(qū)、健側(cè)腦組織區(qū)代謝物及ADC值的相對值和比值,作統(tǒng)計學分析。結(jié)果在59例腦膠質(zhì)瘤中,r NAA、Cho/Cr、NAA/Cr、NAA/Cho及r ADC在低、高級別組膠質(zhì)瘤比較中差異均有統(tǒng)計學意義(P0.05),而r Cho和r Cr在兩組膠質(zhì)瘤比較中差異無統(tǒng)計學意義(P0.05);經(jīng)受試者工作特征曲線分析發(fā)現(xiàn)r NAA、NAA/Cr、NAA/Cho、r ADC鑒別膠質(zhì)瘤分級的曲線下面積0.5,MRS+r ADC鑒別膠質(zhì)瘤分級的曲線下面積(0.956)單獨運用MRS(0.893)或r ADC的曲線下面積(0.805),MRS+r ADC診斷低、高級別膠質(zhì)瘤的敏感性和特異性分別達88.6%、95.8%。結(jié)論聯(lián)合分析MRS參數(shù)(r NAA、NAA/Cr、NAA/Cho)和DWI參數(shù)(r ADC)對診斷膠質(zhì)瘤分級具有較高的敏感性和特異性,可為臨床治療方案的制定及判斷預后提供幫助。
[Abstract]:Objective to evaluate the diagnostic value of the apparent diffusion coefficient (ADC) of hydrogen proton magnetic resonance spectroscopy (1H-MRS) associated metabolites and diffusion weighted magnetic resonance imaging (DWI) in the grading diagnosis of gliomas. Methods the MRS and DWI images of 59 cases of glioma confirmed by pathology were analyzed retrospectively. According to WHO 2007 standard, the patients were divided into two groups: low grade glioma group (鈪，

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