【摘要】：目的蛋白質(zhì)是影響擴(kuò)散加權(quán)成像(DWI)信號(hào)及表觀擴(kuò)散系數(shù)(ADC)值的主要因素,使囊液于DWI上呈高信號(hào),ADC值降低,但在實(shí)際工作中并非完全如此,本研究擬深入了解蛋白質(zhì)的類型、濃度對(duì)其的影響。材料與方法通過(guò)在體外制作不同濃度的白蛋白溶液、球蛋白溶液及同濃度不同比例的白蛋白和球蛋白混合溶液體模,采用GE 1.5T超導(dǎo)型MRI成像系統(tǒng),定量研究其對(duì)DWI信號(hào)和ADC值的影響。結(jié)果 1 ADC值與白蛋白及球蛋白溶液濃度呈線性負(fù)相關(guān)(37℃時(shí),r白=-0.849,P白0.05;r球=-0.843,P球0.05;40℃時(shí),r白=-0.894,P白0.05;r球=-0.819,P球0.05);DWI信號(hào)強(qiáng)度與白蛋白溶液的濃度呈線性正相關(guān)(37℃時(shí),r=0.753,P0.05;40℃時(shí),r=0.845,P0.05),而與球蛋白溶液的濃度無(wú)相關(guān)性(37℃時(shí),r=-0.222,P0.05;40℃,r=-0.270,P0.05)。2相同濃度和溫度下,白蛋白溶液DWI信號(hào)強(qiáng)度高于球蛋白溶液(t=3.96,P0.001),ADC值差異無(wú)統(tǒng)計(jì)學(xué)意義(t=0.61,P0.05)。結(jié)論通過(guò)對(duì)囊液DWI及ADC值的定量分析,可以初步了解囊液的性質(zhì),從而為體內(nèi)囊性病變的定性診斷提供理論依據(jù)。
[Abstract]:Objective protein is the main factor that affects diffusion weighted imaging (DWI) signal and apparent diffusion coefficient (ADC), which reduces the (ADC) value of cystic fluid on DWI, but it is not exactly the case in practice. The effect of concentration on it. Materials and methods GE 1.5T superconducting MRI imaging system was used to fabricate different concentrations of albumin solution, globulin solution and mixed solution of albumin and globulin in vitro. The effect on DWI signal and ADC value was studied quantitatively. Results 1 there was a linear negative correlation between the ADC value and the concentration of albumin and globulin solution. The signal intensity of Albumin and globulin solution was positively correlated with the concentration of albumin solution at 37 鈩，

本文編號(hào)：2241486