【摘要】：目的：探討年齡和性別因素對(duì)健康志愿者腎臟ADC值的影響。材料與方法：2012年6月至2013年8月共100名健康志愿者納入本研究（其中男女各50名，年齡18-69歲，平均44歲），所有志愿者腎功能正常、沒(méi)有泌尿系統(tǒng)疾病和高血壓等基礎(chǔ)病。根據(jù)年齡分為5個(gè)組（18-29歲，30-39歲，40-49歲，50-59歲和60-69歲），每組各20名，在3.0T磁共振掃描儀上行腎臟MR常規(guī)平掃和RT-DWI成像（b值采用800s/mm2），測(cè)量腎實(shí)質(zhì)ADC值并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果：1、5個(gè)年齡段腎實(shí)質(zhì)ADC值依次為(2.066±0.099)×10-3mm2/s、(2.059±0.124)×10-3mm2/s、(2.034±0.103)×10-3mm2/s、(1.985±0.172)×10-3mm2/s、(1.943±0.125)×10-3mm2/s，各組間具有統(tǒng)計(jì)學(xué)差異(F=3.375，P0.05)。2、5個(gè)不同年齡段男性腎實(shí)質(zhì)ADC值依次為(2.087±0.094)×10-3mm2/s、(2.086±0.146)×10-3mm2/s、(2.042±0.117)×10-3mm2/s、(2.041±0.205)×10-3mm2/s、(1.979±0.122)×10-3mm2/s；女性腎實(shí)質(zhì)ADC值依次為(2.060±0.126)×10-3mm2/s、(2.031±0.097)×10-3mm2/s、(2.026±0.092)×10-3mm2/s、(1.929±0.115)×10-3mm2/s、(1.907±0.124)×10-3mm2/s。5個(gè)不同年齡組男性平均ADC值均大于女性，差異沒(méi)有統(tǒng)計(jì)學(xué)意義（P0.05）。結(jié)論：健康志愿者腎臟ADC值受年齡和性別的影響：伴隨年齡的增長(zhǎng)，健康志愿者腎實(shí)質(zhì)ADC值呈減小的趨勢(shì)；同一年齡段男性和女性ADC值無(wú)顯著差別。因此，DWI成像在臨床應(yīng)用時(shí)應(yīng)考慮到年齡和性別因素對(duì)ADC值的影響。 第二部分健康志愿者腎臟1.5T和3.0T磁共振擴(kuò)散加權(quán)成像的對(duì)比研究 目的：探討不同場(chǎng)強(qiáng)（1.5T和3.0T）對(duì)ADC值測(cè)量和圖像質(zhì)量的影響。材料與方法：2012年6月至2013年12月共150名健康志愿者（其中男女各75名，年齡18-73歲，平均38歲）納入本研究，根據(jù)年齡分為5個(gè)組（18-29歲，30-39歲，40-49歲，50-59歲和60-69歲），每組各30名，同一志愿者分別在 1.5T與3.0T磁共振掃描儀上進(jìn)行腎臟FB-DWI和RT-DWI成像（b值均采用800s/mm2）。通過(guò)配對(duì)t檢驗(yàn)比較兩種場(chǎng)強(qiáng)DWI圖像的信噪比（SNR），通過(guò)單因素方差分析進(jìn)行比較腎臟不同部位（上、中和下部）ADC值差異，通過(guò)Pearson相關(guān)分析比較不同場(chǎng)強(qiáng)ADC值測(cè)量的一致性。結(jié)果：1、FB-DWI圖像3.0T和1.5T MR的SNR分別為（66.500±14.776）、（51.570±8.578），差異具有統(tǒng)計(jì)學(xué)意義（P0.05）；RT-DWI圖像3.0T和1.5T MR的SNR分別為（66.611±20.748）、（44.989±11.461），差異具有統(tǒng)計(jì)學(xué)意義（P0.05）。 2、1.5T MR腎臟上部、中部和下部的ADC值分別為(1.998±0.102)×10-3mm2/s、(2.157±0.166)×10-3mm2/s、(2.050±0.183)×10-3mm2/s，3.0T MR腎臟上部、中部和下部的ADC值分別為(2.042±0.094)×10-3mm2/s、(2.073±0.147)×10-3mm2/s、(1.947±0.086)×10-3mm2/s，同一場(chǎng)強(qiáng)腎臟三個(gè)部位的ADC值無(wú)統(tǒng)計(jì)學(xué)差異(1.5T：F=2.485，P0.05；3.0T：F=3.107，P0.05)，腎臟同一部位在不同場(chǎng)強(qiáng)下ADC值無(wú)統(tǒng)計(jì)學(xué)差異（P0.05）。3、1.5T MR5個(gè)年齡段腎實(shí)質(zhì)ADC值依次為(2.165±0.162)×10-3mm2/s、(2.145±0.157)×10-3mm2/s、(2.142±0.150)×10-3mm2/s、(2.127±0.183)×10-3mm2/s、(2.079±0.119)×10-3mm2/s， 3.0T MR5個(gè)年齡段腎實(shí)質(zhì)ADC值依次為(2.075±0.123)×10-3mm2/s、(2.066±0.117)×10-3mm2/s、(2.033±0.108)×10-3mm2/s、(1.971±0.127)×10-3mm2/s、(1.942±0.099)×10-3mm2/s。4、1.5T和3.0T健康腎臟ADC值測(cè)量Pearson相關(guān)系數(shù)為0.796。結(jié)論：3.0T腎臟DWI圖像信噪比高于1.5T；同一b值（b=800s/mm2）條件下，1.5T和3.0T磁共振在不同部位和不同年齡段的腎臟ADC值差別不顯著，，二者具有良好的一致性。
[Abstract]:Materials and Methods: From June 2012 to August 2013, a total of 100 healthy volunteers (50 males and 50 females, aged 18-69, average 44 years) were enrolled in this study. All the volunteers had normal renal function and no urinary system diseases or hypertension. The patients were divided into 5 groups (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The ADC values of renal parenchyma were measured and statistically analyzed by routine MR plain scan and RT-DWI on 3.0T MR scanner. 4) ((10-10-3 mm 2/s, (2.034 [(0.103) ((2.034 (0.103) [(2.034 (0.103) ((1.985 (0.172) ((1.985 (0.172) [(1.943 ((0.125) (0.125) (10-3 mm 2/s), (1.943 (0.125) ((F = 3.375, P 0.05). 2, the ADC values of renal parenchyrenal parenchymal ADC values of male kidnin five age groups were (2.087 ((2.087 ((0.-3mm2/s, (2.041 +0.205) *10-3mm2/s, (1.979) The ADC values of female renal parenchyma were (2.060.126) The ADC values of kidney parenchyma in healthy volunteers decreased with the increase of age, and there was no significant difference between the ADC values of men and women in the same age group.
Comparative study of 1.5T and 3.0T diffusion weighted imaging in kidney of second healthy volunteers
Materials and Methods: From June 2012 to December 2013, 150 healthy volunteers (75 males and 75 females, 18-73 years old, average 38 years old) were included in this study. They were divided into 5 groups according to their ages (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The same volunteer is in the same place.
FB-DWI and RT-DWI were performed on 1.5T and 3.0T magnetic resonance scanners (b values were 800s/mm2). Signal-to-noise ratios (SNR) of DWI images were compared by paired t test. The differences of ADC values in different parts of the kidney (upper, middle and lower) were compared by one-way ANOVA. Pearson correlation analysis was used to compare the ADC values measured at different field strengths. Results: 1, the SNR of FB-DWI images 3.0T and 1.5T MR were (66.500 + 14.776) and (51.570 + 8.578) respectively, the difference was statistically significant (P 0.05); the SNR of RT-DWI images 3.0T and 1.5T MR were (66.611 + 20.748) and (44.989 + 11.461), respectively, and the difference was statistically significant (P 0.05).
The ADC values of the upper, middle and lower parts of 2,1.5 T MR kidneys were (1.998 (+0.102), (1.998 (+0.102), (2.157 (+0.166), (2.157 (+0.166) (+10-3 mm2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.042 2.042 (+0.094) (+10-3 mm2/s,, (2.073 (+0.147) (+0.147)x 10-3 mm2/s, (1.947 /s, AD in three parts of the same field There was no significant difference in ADC values (1.5T:F=2.485, P 0.05; 3.0 T:F:F=3.107, P 0.05; 3.0 T:F=3.107, P 0.05). There was no significant difference in ADC values at the same part of kidnat different field intensities (P 0.05). The ADC values of renal parenchywas (2.165 +0.162) ((2.165 +0.162)x 10-3 mm2/s, (2.145 +0.157)x 10-3 mm2 / s, (2.142 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 150)x 10-10-3 mm2 / s, (2.150)x 10-3 mm2(2.079 + 0.119) * 10-3mm2/s,
The ADC values of kidney parenchyma in 5 age groups of 3.0T MR5 were (2.075 +0.123) ((2.075 +0.123)x 10-3 mm2/s, (2.066 +0.117)x 10-3 mm2/s, (2.033 [0.108)x 10-3 mm2/s, (2.033 [(2.033 [0.108)x 10-3 mm2/s, (1.971 [0.971 [0.127 [(1.971.971 [0.127) [(1.942 +0.099)x 10-3 mm2 / S 2 / s. 3 mm2 / s. 4 4, 1.942 The ratio is higher than 1.5T; the same b value (b=800s/mm2) 1.5T and 3.0T MR showed no significant difference in the ADC values of kidneys at different locations and at different ages, and the two had good consistency.
【學(xué)位授予單位】：中國(guó)人民解放軍醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R445.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 鄒利光;王文獻(xiàn);;3.0T磁共振成像的特點(diǎn)和技術(shù)對(duì)策[J];重慶醫(yī)學(xué);2010年07期

2 康建蘊(yùn);影響磁共振彌散加權(quán)成像信號(hào)的因素[J];大連醫(yī)科大學(xué)學(xué)報(bào);2004年02期

3 徐學(xué)勤;陳克敏;方文強(qiáng);;腎臟MR擴(kuò)散加權(quán)成像的臨床應(yīng)用[J];放射學(xué)實(shí)踐;2008年10期

4 鐘建國(guó);徐亮;龔建平;張博;錢(qián)銘輝;;腎臟體積與性別和年齡及體重參數(shù)的關(guān)系分析[J];放射學(xué)實(shí)踐;2009年06期

5 夏爽;祁吉;;MR并行采集技術(shù)的優(yōu)勢(shì)[J];國(guó)外醫(yī)學(xué)(臨床放射學(xué)分冊(cè));2006年05期

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