【摘要】：目的探討采取磁共振彌散張量成像技術(shù)對帕金森病(PD)患者實(shí)施早期診斷及定量分析的臨床意義。方法將2013-2014年在廣東省第二人民醫(yī)院就診并確診為PD患者30例以及健康對照組30例進(jìn)行顱腦10個方向磁共振彌散張量成像(DTI)掃描,并分析其顱腦兩側(cè)黑質(zhì)、丘腦、腦橋、小腦上腳及中腳的各向異性分?jǐn)?shù)(FA)值及表觀散系數(shù)(ADC)值變化情況。結(jié)果經(jīng)統(tǒng)計學(xué)分析,在該研究的感興趣區(qū)域內(nèi),兩組間除黑質(zhì)區(qū)FA值有差異外(t黑質(zhì)=4.42,P0.05),其他區(qū)域差異無統(tǒng)計學(xué)意義,且黑質(zhì)區(qū)不同部位差異有所不同,其中以黑質(zhì)頭部FA值差異最大(t頭部=4.52,P0.05),且ROC曲線面積為0.836;同時,PD組小腦上腳ADC值與健康組也具有一定差異(t小腦上腳=2.37,P=0.028)。結(jié)論 DTI技術(shù)在帕金森病早期診斷中具有實(shí)際應(yīng)用價值,尤其是當(dāng)黑質(zhì)頭部的FA值變化幅度較大時,帕金森病發(fā)病率更高。
[Abstract]:Objective to investigate the clinical significance of early diagnosis and quantitative analysis of (PD) patients with Parkinson's disease by magnetic resonance diffusion Zhang Liang imaging. Methods from 2013 to 2014, 30 patients with PD diagnosed at the second people's Hospital of Guangdong Province and 30 healthy controls were examined by 10 directions diffusion-weighted Zhang Liang (DTI) scan, and their bilateral substantia nigra, thalamus and pons were analyzed. The changes of anisotropic fraction (FA) value and apparent dispersion coefficient (ADC) of the upper and middle feet of the cerebellum. Results by statistical analysis, in the region of interest in the study, there was a difference in FA value between the two groups except in the substantia nigra (t substantia nigra 4.42), but there was no significant difference in other regions, and the difference in different parts of the substantia nigra was different between the two groups. The FA value of the substantia nigra head was the largest (t head 4.52% P0.05), and the area of ROC curve was 0.836, and the ADC value of the superior cerebellum of PD group was also different from that of the healthy group (2.37% P0. 028). Conclusion DTI technique has practical value in the early diagnosis of Parkinson's disease, especially when the change of FA value of substantia nigra head is large, the incidence of Parkinson's disease is higher.
【作者單位】： 廣東省第二人民醫(yī)院神經(jīng)內(nèi)科;廣東省第二人民醫(yī)院影像科;
【基金】：廣東省科技計劃項(xiàng)目(No:2011B031800168)
【分類號】：R445.2;R742.5

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