腦老化過(guò)程中扣帶回不同區(qū)域的rs-fMRI研究
發(fā)布時(shí)間：2018-07-22 12:26
【摘要】：目的:應(yīng)用靜息態(tài)功能磁共振成像(rs-f MRI)中的低頻振幅(ALFF)及功能連接(FC)中的種子點(diǎn)相關(guān)分析方法,探討中老年人與年輕人之間扣帶回不同區(qū)域在靜息態(tài)狀態(tài)下大腦活動(dòng)的差異。方法:將符合納入標(biāo)準(zhǔn)的121名健康右利手志愿者,按年齡分為兩組:年輕組60名,其中男23名,女37名,年齡范圍22-31歲,平均年齡(26.2±1.9)歲;中老年組61名,其中男23名,女38名,年齡范圍45-65歲,平均年齡(52.6±5.9)歲。將收集的被試者依次行靜息態(tài)功能磁共振掃描,并將扣帶回不同區(qū)域(AAL模板)的數(shù)據(jù),用功能磁共振圖像處理軟件(DPARSFA、SPM、REST)進(jìn)行預(yù)處理、ALFF、FC結(jié)果的計(jì)算以及統(tǒng)計(jì)學(xué)分析,經(jīng)過(guò)Alphasim校正,最終將經(jīng)過(guò)兩樣本T檢驗(yàn)的結(jié)果疊加到rest軟件自帶的標(biāo)準(zhǔn)T2WI圖像上進(jìn)行顯示,觀察中老年人與年輕人靜息態(tài)下扣帶回不同區(qū)域的腦活動(dòng)是否存在差異(P0.01),觀察有統(tǒng)計(jì)學(xué)意義的活動(dòng)團(tuán)塊的腦區(qū)定位、MNI坐標(biāo)、團(tuán)塊的大小及其t值。結(jié)果:1 ALFF結(jié)果:1)靜息狀態(tài)下,中老年組較年輕組扣帶回不同區(qū)域(AAL模板)并不是整體性增強(qiáng)或減弱,其內(nèi)部部分團(tuán)塊活動(dòng)有差別,并可得出有統(tǒng)計(jì)學(xué)意義團(tuán)塊的大小、MNI坐標(biāo)及其t值;2)中老年組與年輕組比較,扣帶回部分區(qū)域(31、32、35、36區(qū))局部ALFF值減低,部分區(qū)域(33、34區(qū))ALFF值未出現(xiàn)有統(tǒng)計(jì)學(xué)意義的變化。2 FC結(jié)果:分別以AAL模板中的扣帶回不同區(qū)域(31-36區(qū))為種子區(qū)域,利用功能連接的方法得出的中老年組較年輕組功能連接強(qiáng)度減弱的區(qū)域基本如下:1)左側(cè)扣帶回前部及其側(cè)面環(huán)繞的腦回(31區(qū)):雙側(cè)小腦后葉、右側(cè)海馬旁回、左側(cè)顳上回、右側(cè)舌回、胼胝體右側(cè)份、右側(cè)島葉、楔前葉;2)右側(cè)扣帶回前部及其側(cè)面環(huán)繞的腦回(32區(qū)):左側(cè)小腦后葉、右側(cè)海馬旁回、雙側(cè)顳上回、右側(cè)島葉、右側(cè)額葉、楔前葉;3)左側(cè)扣帶回中部及其側(cè)面環(huán)繞的腦回(33區(qū)):右側(cè)小腦后葉、左側(cè)顳上回、右側(cè)小腦前葉、左側(cè)海馬旁回、右側(cè)額下回、右側(cè)枕下回、胼胝體、右側(cè)額上回;4)右側(cè)扣帶回中部及其側(cè)面環(huán)繞的腦回(34區(qū)):雙側(cè)顳上回、右側(cè)海馬旁回、胼胝體;5)左側(cè)扣帶回后部及其側(cè)面環(huán)繞的腦回(35區(qū)):雙側(cè)海馬旁回、胼胝體左側(cè)份;6)右側(cè)扣帶回后部及其側(cè)面環(huán)繞的腦回(36區(qū)):右側(cè)顳上回、胼胝體。結(jié)論:1靜息狀態(tài)下,用ALFF的方法發(fā)現(xiàn)中老年組較年輕組(即隨年齡增加)扣帶回不同區(qū)域并不是整體性增強(qiáng)或減弱,扣帶回前部及后部(31、32、35、36區(qū))的局部神經(jīng)元活動(dòng)減弱,扣帶回中部(33、34區(qū))的神經(jīng)元活性未見(jiàn)有統(tǒng)計(jì)學(xué)意義的變化,說(shuō)明腦老化過(guò)程中,首先累及的是扣帶回的前部及后部,中部累及較少;2靜息狀態(tài)下,用FC的方法可發(fā)現(xiàn)中老年組較年輕組扣帶回不同區(qū)域連接強(qiáng)度下降的腦區(qū)不盡相同,有其各自連接強(qiáng)度減弱的腦區(qū),這些腦區(qū)部分位于默認(rèn)網(wǎng)絡(luò)(DMN)區(qū)域內(nèi),說(shuō)明腦老化過(guò)程中扣帶回不同區(qū)域均不同程度累及默認(rèn)網(wǎng)絡(luò),反映了腦老化對(duì)腦功能有負(fù)面影響。
[Abstract]:Objective: to investigate the difference of cerebral activity in different regions of cingulate gyrus between middle-aged, aged and young people in resting functional magnetic resonance imaging (rs-f) by using the methods of low-frequency amplitude (ALFF) and seed point correlation in functional junction (FC). Methods: 121 healthy right-handedness volunteers who met the inclusion criteria were divided into two groups according to their age: young group (n = 60), male (23), female (37), aged 22-31 years (mean age: 26.2 鹵1.9), middle aged group (n = 61), male (n = 23) and female (n = 38). The age range was 45-65 years, the average age was (52.6 鹵5.9) years. The collected subjects were scanned by resting functional magnetic resonance imaging (fMRI), and cingulate data were brought back to different regions (AAL template). The results of the FFFC were calculated and analyzed by the functional magnetic resonance image processing software (DPARSFAS) SPMREST, and corrected by Alphasim. Finally, the results of the two samples T-test are superimposed on the standard T2WI images of the rest software. To observe the difference of brain activity in different regions of cingulate gyrus between middle aged and young people (P0.01), to observe the MNI coordinates, the size and t value of cingulate gyrus. Results under the condition of rest, the cingulate region (AAL template) of the middle-aged and aged group was not enhanced or weakened, but the activity of some lumps in the middle and old group was different. It can be concluded that the MNI coordinate and t value of the mass are statistically significant. Compared with the young group, the ALFF values in the cingulate part of the middle and old age group (31n 32n 35N 36) are lower than those in the younger group. There was no significant change in ALFF value in some regions (33 / 34). 2 FC results: the different regions of cingulate gyrus (region 31-36) in AAL template were taken as seed regions, respectively. In the middle and old age group, the intensity of functional connection was decreased in the following areas: 1) the anterior cingulate gyrus and the lateral gyrus around the left cingulate gyrus (area 31): bilateral posterior cerebellar lobe, right parahippocampal gyrus, left superior temporal gyrus, bilateral posterior cerebellar lobe, right para-hippocampal gyrus, and left superior temporal gyrus. Right lingual gyrus, right part of corpus callosum, right insular lobe, right precuneial lobe (2) right anterior cingulate gyrus and its lateral gyrus (32 regions): left posterior cerebellar lobe, right parahippocampal gyrus, bilateral superior temporal gyrus, right insular lobe, right frontal lobe, right lateral cingulate gyrus, right superior temporal gyrus, right insular lobe, right frontal lobe. Left cingulate gyrus in the middle of the cingulate gyrus and its lateral circumference (area 33): right posterior lobe, left superior temporal gyrus, right anterior cerebellar lobe, left parahippocampal gyrus, right inferior frontal gyrus, right inferior occipital gyrus, corpus callosum, right inferior frontal gyrus, right inferior occipital gyrus, and corpus callosum. Right superior frontal gyrus 4) right middle cingulate gyrus and its lateral circumference gyrus (region 34): bilateral superior temporal gyrus, right para-hippocampal gyrus, corpus callosum 5) left posterior cingulate gyrus and its lateral circumferential gyrus (region 35): bilateral pariprahippocampal gyrus, The right gyrus around the posterior cingulate gyrus and its lateral region (area 36): right superior temporal gyrus, corpus callosum. Conclusion the ALFF method was used to find that different areas of cingulate gyrus were not enhanced or weakened in different regions of cingulate gyrus in the younger group (i.e. with age), but the local neuronal activity in the anterior and posterior cingulate gyrus (31 ~ 32n ~ (35) ~ (36) was decreased by using the ALFF method in the rest state of the cingulate gyrus. There was no significant change in neuronal activity in the middle cingulate gyrus (area 33), which indicated that the anterior and posterior cingulate gyrus were involved in the process of brain aging, and in the middle of the cingulate gyrus, there was no significant change in the neuronal activity in the middle part of the cingulate gyrus. By using FC method, it was found that the different regions of the cingulate gyrus decreased in different regions of the middle and old group, and some of these regions were located in the default network (DMN). The results showed that the default network was involved in different areas of cingulate gyrus during brain aging, which reflected the negative effect of brain aging on brain function.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R445.2;R742
本文編號(hào)：2137462
[Abstract]:Objective: to investigate the difference of cerebral activity in different regions of cingulate gyrus between middle-aged, aged and young people in resting functional magnetic resonance imaging (rs-f) by using the methods of low-frequency amplitude (ALFF) and seed point correlation in functional junction (FC). Methods: 121 healthy right-handedness volunteers who met the inclusion criteria were divided into two groups according to their age: young group (n = 60), male (23), female (37), aged 22-31 years (mean age: 26.2 鹵1.9), middle aged group (n = 61), male (n = 23) and female (n = 38). The age range was 45-65 years, the average age was (52.6 鹵5.9) years. The collected subjects were scanned by resting functional magnetic resonance imaging (fMRI), and cingulate data were brought back to different regions (AAL template). The results of the FFFC were calculated and analyzed by the functional magnetic resonance image processing software (DPARSFAS) SPMREST, and corrected by Alphasim. Finally, the results of the two samples T-test are superimposed on the standard T2WI images of the rest software. To observe the difference of brain activity in different regions of cingulate gyrus between middle aged and young people (P0.01), to observe the MNI coordinates, the size and t value of cingulate gyrus. Results under the condition of rest, the cingulate region (AAL template) of the middle-aged and aged group was not enhanced or weakened, but the activity of some lumps in the middle and old group was different. It can be concluded that the MNI coordinate and t value of the mass are statistically significant. Compared with the young group, the ALFF values in the cingulate part of the middle and old age group (31n 32n 35N 36) are lower than those in the younger group. There was no significant change in ALFF value in some regions (33 / 34). 2 FC results: the different regions of cingulate gyrus (region 31-36) in AAL template were taken as seed regions, respectively. In the middle and old age group, the intensity of functional connection was decreased in the following areas: 1) the anterior cingulate gyrus and the lateral gyrus around the left cingulate gyrus (area 31): bilateral posterior cerebellar lobe, right parahippocampal gyrus, left superior temporal gyrus, bilateral posterior cerebellar lobe, right para-hippocampal gyrus, and left superior temporal gyrus. Right lingual gyrus, right part of corpus callosum, right insular lobe, right precuneial lobe (2) right anterior cingulate gyrus and its lateral gyrus (32 regions): left posterior cerebellar lobe, right parahippocampal gyrus, bilateral superior temporal gyrus, right insular lobe, right frontal lobe, right lateral cingulate gyrus, right superior temporal gyrus, right insular lobe, right frontal lobe. Left cingulate gyrus in the middle of the cingulate gyrus and its lateral circumference (area 33): right posterior lobe, left superior temporal gyrus, right anterior cerebellar lobe, left parahippocampal gyrus, right inferior frontal gyrus, right inferior occipital gyrus, corpus callosum, right inferior frontal gyrus, right inferior occipital gyrus, and corpus callosum. Right superior frontal gyrus 4) right middle cingulate gyrus and its lateral circumference gyrus (region 34): bilateral superior temporal gyrus, right para-hippocampal gyrus, corpus callosum 5) left posterior cingulate gyrus and its lateral circumferential gyrus (region 35): bilateral pariprahippocampal gyrus, The right gyrus around the posterior cingulate gyrus and its lateral region (area 36): right superior temporal gyrus, corpus callosum. Conclusion the ALFF method was used to find that different areas of cingulate gyrus were not enhanced or weakened in different regions of cingulate gyrus in the younger group (i.e. with age), but the local neuronal activity in the anterior and posterior cingulate gyrus (31 ~ 32n ~ (35) ~ (36) was decreased by using the ALFF method in the rest state of the cingulate gyrus. There was no significant change in neuronal activity in the middle cingulate gyrus (area 33), which indicated that the anterior and posterior cingulate gyrus were involved in the process of brain aging, and in the middle of the cingulate gyrus, there was no significant change in the neuronal activity in the middle part of the cingulate gyrus. By using FC method, it was found that the different regions of the cingulate gyrus decreased in different regions of the middle and old group, and some of these regions were located in the default network (DMN). The results showed that the default network was involved in different areas of cingulate gyrus during brain aging, which reflected the negative effect of brain aging on brain function.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R445.2;R742
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