發(fā)布時(shí)間：2018-06-28 11:45

  本文選題：聲學(xué)造影 + 微泡��； 參考：《臨床心血管病雜志》2017年12期

【摘要】：目的:比較使用手振激活加血生理鹽水、手振激活50%葡萄糖溶液與傳統(tǒng)手振激活生理鹽水進(jìn)行右心聲學(xué)造影的穩(wěn)定性、有效性、敏感性、安全性,為臨床選擇右心聲學(xué)造影劑提供參考。方法:選取2015-01-2017-08成都市第三人民醫(yī)院、成都大學(xué)附屬醫(yī)院門診及住院患者中懷疑有右向左分流(RLS)的患者(不明原因腦卒中、短暫性腦缺血發(fā)作、先兆性偏頭痛)105例。所有患者均采用振蕩20次的3種不同手振聲學(xué)造影劑進(jìn)行造影。記錄患者右心微泡顯影持續(xù)時(shí)間;觀察RLS情況并進(jìn)行半定量分析;監(jiān)測(cè)患者造影前后的心率、血壓、呼吸頻率、血氧飽和度。結(jié)果:手振加血激活生理鹽水、手振激活50%葡萄糖溶液較傳統(tǒng)手振激活生理鹽水空氣微氣泡使用時(shí)右心微泡顯影持續(xù)時(shí)間長(zhǎng),差異有統(tǒng)計(jì)學(xué)意義(P0.01),手振加血生理鹽水空氣微氣泡較手振50%葡萄糖溶液空氣微氣泡右心微泡顯影持續(xù)時(shí)間長(zhǎng),差異有統(tǒng)計(jì)學(xué)意義(P0.05);手振加血激活生理鹽水、手振激活50%葡萄糖溶液較傳統(tǒng)手振激活生理鹽水對(duì)于RLS檢出率更高,差異有統(tǒng)計(jì)學(xué)意義(P0.05),手振加血激活生理鹽水與手振激活50%葡萄糖溶液對(duì)RLS檢出率無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),但手振加血激活生理鹽水對(duì)于Ⅱ、Ⅲ級(jí)分流敏感度更高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);所有患者造影前后心率、血壓、呼吸頻率、血氧飽和度差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:手振加血激活生理鹽水、手振激活50%葡萄糖溶液是2種經(jīng)濟(jì)、安全、有效的右心聲學(xué)造影劑,尤其是手振加血激活生理鹽水,其造影效果較傳統(tǒng)手振激活生理鹽水更好,制備方便,值得臨床推廣。
[Abstract]:Objective: to compare the stability, efficacy, sensitivity and safety of dextrose 50% dextrose solution with hand vibration activation plus blood saline in contrast with conventional manual vibration activated saline. To provide a reference for clinical choice of right voice contrast agent. Methods: 105 patients with suspected right to left shunt (RLS) (unknown cause stroke, transient ischemic attack, aura migraine) were selected from Chengdu third people's Hospital and Chengdu University affiliated Hospital in 2015-01-2017-08. All patients were examined with 3 different hand-oscillating contrast agents with 20 oscillations. The duration of right ventricular microbubble development was recorded, RLS was observed and semi-quantitatively analyzed, heart rate, blood pressure, respiratory frequency and oxygen saturation were monitored before and after angiography. Results: the development duration of right ventricular microbubbles was longer when hand vibration combined with blood activated normal saline, 50% glucose solution was activated by hand vibration than by traditional hand vibration activation of physiological saline air microbubbles. The difference was statistically significant (P0.01). The development time of right heart microbubble was longer than that of 50% glucose solution (P0.05). The detection rate of RLS in 50% glucose solution activated by hand vibration was higher than that in normal saline activated by hand vibration. The difference was significant (P0.05). There was no significant difference in RLS detection rate between hand vibration plus blood activated saline and 50% glucose solution (P0.05), but the sensitivity of hand vibration plus blood activated saline to grade 鈪，

本文編號(hào)：2077885