本文選題：視皮質(zhì) + 纖維構(gòu)筑�。� 參考：《山東大學(xué)》2014年碩士論文

【摘要】：研究目的 應(yīng)用高分辨率相位差增強成像(phase difference enhanced imaging, PADRE)技術(shù)研究正常成人Gennari紋的顯示情況,并測算初級視覺皮質(zhì)及視輻射的相位值,探討利用PADRE技術(shù)研究活體大腦皮質(zhì)纖維構(gòu)筑的可行性。 資料與方法 本研究經(jīng)山東省醫(yī)學(xué)影像學(xué)研究所倫理學(xué)委員會同意并獲得受檢者知情同意。研究對象為34名健康志愿者,其中男20例,女14例,年齡21-50歲,平均年齡30.4±8.0歲。采用荷蘭Philips Achieva TX3.0T超導(dǎo)MR掃描儀,8通道相控陣頭線圈為接收線圈。對所有受檢者行高分辨率PADRE技術(shù)顱腦成像,并對獲得的原始圖像分別進行組織增強(tissue enhancement, TE)、血管增強(vessel enhancement, VE)及相位增強(PADRE)三種模式的重建。 (1)正常成人Gennari紋的顯示情況評價在未知圖像重建模式情況下,由2位具有高年資神經(jīng)放射診斷經(jīng)驗的醫(yī)師分別評估所有受試者TE、VE及PADRE圖像上枕葉灰白質(zhì)的顯示情況,重點對3組圖像上Gennari紋的顯示情況進行獨立評價,評分標準為：0分：未見顯示Gennari紋；1分：不能明確辨認Gennari紋,但隱約可見；2分：可以辨認Gennari紋,但走行欠連續(xù)或不能顯示其在皮質(zhì)中走行位置；3分,可以明確辨認Gennari紋,且走行連續(xù),可分辨在皮質(zhì)中的位置；此外,經(jīng)初級視覺皮質(zhì)垂直于皮質(zhì)表面劃一直線感興趣區(qū)(region of interest, ROI)并計算該ROI的信號強度曲線,觀察在該曲線上Gennari紋走行處有無信號強度的降低。對于2名閱片者間評分結(jié)果行Kappa一致性檢驗。對于PADRE、TE及VE圖像上Gennari紋的評分值,采用Wilcoxon符號秩和檢驗進行分析；p0.05為差異具有統(tǒng)計學(xué)意義。 (2)初級視覺皮質(zhì)及視輻射的相位值測量將PADRE原始數(shù)據(jù)以DICOM格式轉(zhuǎn)存至專用電腦上后,采用SPIN軟件進行高通濾波,得到“濾過”的相位圖(filtered phase image, FPI),在FPI上選取兩側(cè)距狀溝前、后的皮質(zhì)以及視輻射走行處設(shè)置圓形ROI測算初級視覺皮質(zhì)及視輻射的相位值。對于所得相位值先行正態(tài)性檢驗,對服從正態(tài)分布的相位值進行配對設(shè)計數(shù)值變量資料的t檢驗。p0.05為差異具有統(tǒng)計學(xué)意義。 結(jié)果 36名志愿者經(jīng)PADRE技術(shù)重建的3組圖像中皮質(zhì)表現(xiàn)為相對高信號,白質(zhì)則為較低信號；3組圖像均可不同程度地顯示Gennari紋,表現(xiàn)為與初級視覺皮質(zhì)表面平行的低信號帶。TE圖像中灰白質(zhì)對比顯示最好,可識別Gennari紋在皮質(zhì)中的走行位置,但是對Gennari紋的顯示較淡；VE圖像中灰白質(zhì)對比較差,不能識別Gennari紋在皮質(zhì)中的走行位置,但是對Gennari紋的顯示較清晰；PADRE圖像中灰白質(zhì)對比較好,可清晰顯示Gennari紋,亦可分辨Gennari紋在皮質(zhì)中的走行位置。在三組圖像中ROI的信號強度曲線上,可以觀察到在Gennari紋的走行處存在明顯的信號強度的降低。 2名評閱者對TE.VE及PADRE圖像上Gennari紋的評分值分別為1.79±0.44、1.84±0.37、2.84±0.37,1.76±0.43、1.82±0.38、2.7±0.41,評閱者間的評分結(jié)果一致性較好(κ=0.823)。2名評閱者在TE、VE及PADRE圖像上對Gennari紋的平均評分值為1.78±0.43、1.83±0.38、2.8±0.39,PADRE圖像上Gennari紋的評分值與其他2組圖像的評分值比較差異具有統(tǒng)計學(xué)意義,PADRE圖像對Gennari紋的顯示優(yōu)于TE和VE圖像(Z=-13.337,p0.01；Z=-13.458,p0.01)。 左、右兩側(cè)初級視覺皮質(zhì)及視輻射的相位值分別為0.2184±0.080,0.216±0.080；-0.45±0.113,-0.436±0.128,雙側(cè)間比較差異無統(tǒng)計學(xué)意義(t=0.150,p0.05；t=-1.136,p0.05)；雙側(cè)初級視覺皮質(zhì)和視輻射的平均相位值為0.21±0.068、-0.447±0.106,二者間差異具有統(tǒng)計學(xué)意義(t=29.681,p0.01)。 結(jié)論 PADRE技術(shù)可以顯示Gennari紋,尤以PADRE圖像顯示最佳,提示PADRE技術(shù)可用于活體大腦皮質(zhì)內(nèi)有髓神經(jīng)纖維的MR成像,這為研究活體大腦皮質(zhì)區(qū)纖維構(gòu)筑與其功能的相關(guān)性提供了一種新方法。
[Abstract]:research objective
The phase difference enhanced imaging (PADRE) technique was used to study the display of Gennari lines in normal adults, and to calculate the phase values of the primary visual cortex and the visual radiation, and to explore the feasibility of using PADRE to study the construction of the living cerebral cortex fibers.
Information and methods
The study was approved by the ethics committee of the Institute of medical imaging of Shandong province. The subjects were 34 healthy volunteers, including 20 men, 14 women, 21-50 years old, and the average age was 30.4 + 8 years. The Holland Philips Achieva TX3.0T superconducting MR scanning instrument was used and the 8 channel phased array head coil was the receiving coil. The subjects were treated with high resolution PADRE technique for brain imaging, and the original images were reconstructed by tissue enhancement (tissue enhancement, TE), vascular enhancement (vessel enhancement, VE) and phase enhancement (PADRE), respectively.
(1) the display situation of Gennari pattern in normal adults was evaluated under the condition of unknown image reconstruction. 2 patients with high annual neuroradiation diagnosis experience were evaluated respectively for the display of the occipital gray matter in the TE, VE and PADRE images of all the subjects, and the display situation of the Gennari pattern on the 3 group images was evaluated independently. : 0 points: no display of Gennari lines; 1 points: can not clearly identify Gennari lines, but vaguely visible; 2: can identify Gennari lines, but the line is not continuous or can not show its position in the cortex; 3 points can clearly identify the lines, and walk continuously, can distinguish the position in the cortex; moreover, through the primary visual cortex vertical On the cortical surface, the region of interest (ROI) is calculated and the signal intensity curve of the ROI is calculated, and the decrease of the signal intensity is observed on the line of Gennari lines on this curve. The Kappa consistency test is performed for the score results between the 2 film readers. For PADRE, TE and VE images, the Gennari marks are used for the Wilcoxon symbols. Rank sum test was used for analysis; P0.05 was statistically significant.
(2) the primary visual cortex and the phase value measurement of the visual radiation are transferred to the special computer in the DICOM format. The SPIN software is used for high pass filtering, and the "filtered" phase diagram (filtered phase image, FPI) is obtained, and the circular ROI measurement is set on the FPI on the FPI, and the posterior cortex and the optic radiation walk. The phase values of the primary visual cortex and the visual radiation. For the first normal test of the obtained phase values, the t test of the data of the paired design numerical variables for the phase values of the normal distribution is statistically significant.
Result
The 3 groups of 36 volunteers, reconstructed by PADRE technique, showed relatively high signal in the cortex, and the white matter was a lower signal. The 3 group images could display the Gennari pattern in varying degrees, showing the best contrast of gray matter in the low signal band.TE images parallel to the primary visual cortex surface, and could identify the walking position of the Gennari lines in the cortex. But the display of Gennari lines is weak; the gray matter in the VE image is poor and can not identify the walking position of the Gennari lines in the cortex, but the display of the Gennari pattern is clearer; the gray matter in the PADRE image is better, can clearly display the Gennari lines, and can also distinguish the walking position of the Gennari lines in the cortex. In the three groups of images, ROI On the signal intensity curve, it is observed that there is a significant decrease in signal intensity at the Gennari stripe.
The scores of the 2 reviewers on the TE.VE and PADRE images were 1.79 + 0.44,1.84 + 0.37,2.84 + 0.37,1.76 + 0.43,1.82 + 0.38,2.7 + 0.41 respectively. The scores of the judges were in good agreement (KB =0.823), and the average score of the.2 names was 1.78 + + 0.39. The difference between the score value of the Gennari pattern on the image and the score of the other 2 sets of images has statistical significance. The display of the PADRE image to the Gennari pattern is superior to the TE and VE images (Z=-13.337, P0.01; Z=-13.458, P0.01).
The phase values of primary visual cortex and optic radiation on both left and right sides were 0.2184 + 0.080,0.216 + 0.080, -0.45 + 0.113 and -0.436 + 0.128. There was no significant difference between bilateral and bilateral (t=0.150, P0.05; t=-1.136, P0.05), and the average phase values of bilateral primary visual cortex and visual radiation were 0.21 + 0.068, -0.447 + 0.106, and there were differences between two. Statistical significance (t=29.681, P0.01).
conclusion
PADRE technique can display Gennari lines, especially in PADRE images, suggesting that PADRE technology can be used in MR imaging of myelinated nerve fibers in the cerebral cortex of the living body, which provides a new method for the study of the correlation between the fibrous architecture and its function in the cerebral cortex of the living body.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R445.2

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