本文選題：骨質疏松 + 血氧水平依賴磁共振成像　； 參考：《哈爾濱工業(yè)大學》2014年碩士論文

【摘要】：骨質疏松是一組以骨量減少,骨呈多孔狀,密度降低,致使骨的強度下降,脆性增加而容易發(fā)生骨折為主要特征的全身性骨骼類疾病。骨質疏松癥的直接后果是骨折,老年人發(fā)生髖部骨折的后果很嚴重,很有可能導致死亡。隨著人類壽命的延長、社會老齡化和人口結構的改變,骨質疏松的發(fā)病率將逐年增加,已發(fā)展成為全球密切關注的健康問題。骨質疏松的病因較多,目前尚未最終闡明。近年來,臨床、流行病學以及組織病理學開始對骨質疏松與人體血管類疾病間關聯性的研究,發(fā)現骨密度與血管疾病之間存在很強的關聯性。血氧代謝是機體能量代謝的重要組成部分,人體的各種生理活動都離不開能量的支持,血氧代謝的異常勢必將導致能量供應不足,從而影響人體的各種生理活動。血氧代謝異常不僅是許多疾病所共有的一個基本病理過程,更是許多疾病引起死亡的重要原因。血氧水平依賴磁共振成像(BOLD-MRI)是一種利用組織中血氧飽和度變化來制造對比的磁共振成像技術,通過對BOLD信號的分析可以獲得組織血氧代謝功能的變化情況,從而可以進一步研究血氧代謝與其他疾病之間的關聯。本文借助BOLD磁共振成像技術為影像手段,通過采用半量化與量化兩種不同的分析方法來研究骨骼肌血液灌注、血氧代謝與骨密度之間的關系,進一步揭示骨質疏松的生理成因。在半量化分析過程中,使用雙指數函數與S型函數對特征曲線進行擬合,獲取了較為穩(wěn)定、準確的特征參數。在量化分析過程中,基于參考區(qū)域建模方法,建立獨立于動脈血氧輸入函數的適用于BOLD信號的血氧代謝動力模型,避免了無法獲得準確動脈血氧輸入函數的影響,并提取相關生理參數進行統(tǒng)計分析。本研究發(fā)現,不同肌肉組織在血液灌注與血氧代謝能力上存在顯著性差異,同時不同骨密度組別間在個別肌肉的血氧代謝功能上存在顯著性差異。研究結果表明,骨密度與周圍組織的血液循環(huán)及血氧代謝存在關聯性,血氧代謝功能的改變可能是誘發(fā)骨質疏松的原因之一。希望通過本課題的研究,能夠為骨質疏松的預防和早期診斷提供幫助。
[Abstract]:Osteoporosis is a group of systemic bone diseases characterized by reduced bone mass, porous bone and decreased density, which leads to the decrease of bone strength and the increase of brittleness, which is liable to fracture. The immediate consequence of osteoporosis is fracture. Hip fractures in the elderly are serious and can lead to death. With the prolongation of human life, the aging of society and the change of population structure, the incidence of osteoporosis will increase year by year. There are many causes of osteoporosis, which have not been finally clarified. In recent years, clinical, epidemiology and histopathology have begun to study the relationship between osteoporosis and vascular diseases, and found that there is a strong correlation between bone mineral density and vascular diseases. Blood oxygen metabolism is an important part of body energy metabolism. Various physiological activities of human body can not be separated from the support of energy. The abnormality of blood oxygen metabolism will inevitably lead to insufficient energy supply, thus affecting various physiological activities of the human body. Abnormal blood oxygen metabolism is not only a basic pathological process common to many diseases, but also an important cause of death caused by many diseases. Blood oxygen level dependent magnetic resonance imaging (BOLD-MRI) is a kind of magnetic resonance imaging technology, which makes use of the change of blood oxygen saturation in tissues to make contrast. The changes of blood oxygen metabolism can be obtained by analyzing the bod signal. Thus, the relationship between blood oxygen metabolism and other diseases can be further studied. In this paper, the relationship between blood perfusion, blood oxygen metabolism and bone mineral density of skeletal muscle was studied by means of bod magnetic resonance imaging. The physiological causes of osteoporosis were further revealed by using semi-quantitative and quantitative analysis methods to study the relationship between blood perfusion, blood oxygen metabolism and bone mineral density (BMD) of skeletal muscle. In the process of semi-quantization analysis, the double exponential function and S-type function are used to fit the characteristic curve, and the more stable and accurate characteristic parameters are obtained. In the process of quantitative analysis, based on the reference region modeling method, a dynamic model of blood oxygen metabolism, which is independent of arterial oxygen input function and suitable for bold signal, is established, which avoids the influence of failure to obtain accurate arterial oxygen input function. The related physiological parameters were extracted for statistical analysis. In this study we found that there were significant differences in blood perfusion and oxygen metabolism between different muscle tissues and significant differences in blood oxygen metabolism function among different bone mineral density groups. The results showed that BMD was associated with blood circulation and blood oxygen metabolism in peripheral tissues, and the change of blood oxygen metabolism function might be one of the causes of osteoporosis. It is hoped that this study will be helpful for the prevention and early diagnosis of osteoporosis.
【學位授予單位】：哈爾濱工業(yè)大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R445.2;R580

【參考文獻】

相關期刊論文 前1條

1 鄧廉夫;;骨組織血流灌注障礙與骨質疏松的發(fā)生發(fā)展[J];中醫(yī)正骨;2013年12期

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本文編號：2017617