本文選題：腦白質(zhì)病 + 進(jìn)行性多灶性　； 參考：《中國醫(yī)學(xué)影像學(xué)雜志》2016年07期

【摘要】：目的探討缺血性腦白質(zhì)病的額頂葉腦白質(zhì)擴(kuò)散峰度表現(xiàn),并評價高級別Fazekas的病灶特點(diǎn)。資料與方法回顧性分析經(jīng)臨床確診為缺血性腦白質(zhì)病的46例患者的擴(kuò)散峰度成像(DKI)資料,Fazekas 0~3級,比較其額頂葉正常腦白質(zhì)及病灶的平均擴(kuò)散峰度(MK)、平均擴(kuò)散系數(shù)(MD)、各向異性分?jǐn)?shù)(FA)、峰度各向異性分?jǐn)?shù)(FA_k)、軸向擴(kuò)散峰度(Ka)、徑向擴(kuò)散峰度(Kr)、軸向擴(kuò)散系數(shù)(Da)、徑向擴(kuò)散系數(shù)(Dr)加權(quán)值的差異。結(jié)果 1病灶加權(quán)MD、Ka、Dr與Fazekas分級呈正相關(guān)(r=0.795、0.863、0.668,P0.05),加權(quán)MK、Kr、Da與Fazekas分級呈負(fù)相關(guān)(r=-0.616、-0.682、-0.807,P0.05);2額頂葉正常白質(zhì)各DKI參數(shù)MK、MD、FA、FAk、Ka、Kr、Da、Dr加權(quán)值與Fazekas分級無明顯相關(guān)性(P0.05)。3 4個Fazekas分級組的額頂葉正常白質(zhì)各參數(shù)MK、MD、FA、FA_k、Ka、Kr、Da、Dr比較,差異有統(tǒng)計學(xué)意義(P0.05),其中Fazekas 0級與Fazekas 3級組各參數(shù)間差異均有統(tǒng)計學(xué)意義(P0.05)。4 4個Fazekas分級組的額頂葉病灶MK、MD、FA、FA_k、Ka、Kr、Da、Dr的加權(quán)值差異均有統(tǒng)計學(xué)意義(P0.05)。5 Fazekas 3組額頂葉病灶的加權(quán)MK值與FA值、加權(quán)Kr與FA值呈正相關(guān)(r=0.69、0.72,P0.05),加權(quán)Kr值與Dr值呈負(fù)相關(guān)(r=-0.95,P0.05)。結(jié)論 DKI能早期反映額頂葉正常白質(zhì)擴(kuò)散峰度變化的差異,能先于T2液體衰減反轉(zhuǎn)恢復(fù)序列敏感地探測出缺血性腦白質(zhì)病額頂葉白質(zhì)病變;DKI可以發(fā)現(xiàn)缺血性腦白質(zhì)病額頂葉白質(zhì)擴(kuò)散峰度的變化特點(diǎn)。
[Abstract]:Objective to investigate the diffusion kurtosis of frontal and parietal white matter in ischemic white matter disease and to evaluate the characteristics of high grade Fazekas. Materials and methods the DKI data of 46 patients with ischemic leukoencephalopathy were retrospectively analyzed. The mean diffusion kurtosis of normal white matter and lesions in the frontal and parietal lobes were compared. The mean diffusion coefficients were MDI, anisotropic fraction, kurtosis, axial diffusion kurtosis, radial diffusion kurtosis, axial diffusion coefficient, radial diffusion kurtosis, radial diffusion coefficient, radial diffusion kurtosis, radial diffusion coefficient. The difference in the weighted value of the coefficient Dr. Results (1) there was a positive correlation between the weighted MDKI and the Fazekas grade. There was no significant correlation between the weighted MKU KrDa and the Fazekas grade. There was a negative correlation between the weighted MKU KrDa and the Fazekas grade. There was a negative correlation between MKI and Fazekas grade. The DKI parameters of the normal white matter of the parietal lobe were not significantly correlated with those of the Fazekas classification group (P 0.05.3). There were significant differences in the parameters between Fazekas grade 0 and Fazekas grade 3. There were significant differences in the weighted MK value and FA value of the frontal and parietal lobe lesions in the Fazekas grade 0 and Fazekas grade 3 groups. The weighted MK value and FA value of the frontal and parietal lobe lesions in the Fazekas grade group were significantly higher than those in the Fazekas grade 3 group (P 0.05.5 Fazekas grade 3), and there were significant differences in the weighted MK values and FA values of the frontal and parietal lobe lesions in the Fazekas grade 0 and Fazekas grade 3 groups. There was a positive correlation between the weighted Kr and the FA value, and a negative correlation between the weighted Kr value and the Dr value. Conclusion DKI can reflect the difference of diffusion kurtosis of normal white matter in frontal parietal lobe early. DKI can detect the change of diffusion kurtosis of white matter in frontal parietal white matter of ischemic white matter disease before T2 fluid attenuated inversion recovery sequence.
【作者單位】： 福建醫(yī)科大學(xué)附屬泉州第一醫(yī)院影像科;福建省石獅市醫(yī)院影像科;
【基金】：泉州市重點(diǎn)科技項(xiàng)目(2014Z39)
【分類號】：R742;R445.2

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