本文選題：肝纖維化 + 肝硬化�。� 參考：《臨床放射學(xué)雜志》2015年02期

【摘要】：目的利用家兔肝纖維化模型評價磁共振彈性成像(MRE)在肝纖維化(HF)病理分期中的價值方法建立肝纖維化實驗組(n=32)、實驗補充組(n=12)、正常對照組(n=15)。對實驗組及正常對照兔行常規(guī)MRI及MRE檢查,測量肝實質(zhì)的硬度(LS)值。HF組實驗兔皮下注射50%CCl4后的第4、5、6、10周分別隨機選擇8只行MRI掃描。以肝臟纖維化病理組織學(xué)診斷為標準,評價第4、5、6、10周MRE與HF病理分期的相關(guān)性,并采用ROC曲線分析MRE的診斷準確性。結(jié)果不同分期HF的LS值之間存在顯著差異(P0.001),隨著HF分期加重,LS值增加。LS與HF分期存在明顯相關(guān)性(r=0.948,P0.001)。LS區(qū)分各組別HF的敏感性、特異性、準確性、陽性預(yù)測值和陰性預(yù)測值分別為:≥S1期93.8%、93.3%、93.6%、96.8%、87.5%;≥S2期95.8%、95.7%、95.7%、95.8%、95.7%;≥S3期93.8%、96.8%、95.8%、93.8%、98.8%;S4期100%、97.4%、97.9%、100%、88.9%。結(jié)論 MRE作為一種安全、可靠地?zé)o創(chuàng)性HF分期技術(shù),可為臨床診治、縱向研究提供一種重要的補充手段。
[Abstract]:Objective to evaluate the value of magnetic resonance elastography (Mre) in the pathological staging of hepatic fibrosis in rabbits. Methods the experimental group of hepatic fibrosis was established. Routine MRI and MRE were performed in the experimental group and the normal control group. The hardness of liver parenchyma was measured. In HF group, 8 rabbits were randomly selected for MRI scanning 10 weeks after subcutaneous injection of 50l4. Based on the histopathological diagnosis of hepatic fibrosis, the correlation between MRE and HF staging was evaluated at the 10th week of the 4th 5th week, and the diagnostic accuracy of MRE was analyzed by ROC curve. Results there was significant difference in LS value among different HF stages (P 0.001). With the increase of LS value in HF stage, there was a significant correlation between LS and HF staging. The sensitivity, specificity and accuracy of HF were distinguished by 0.948% P 0.001. LS. The positive predictive value and the negative predictive value were as follows: 鈮，

本文編號：1908984