本文選題：多發(fā)性骨髓瘤 + 彌漫浸潤性病變�。� 參考：《中國醫(yī)學(xué)科學(xué)院學(xué)報》2017年01期

【摘要】：目的探討第3代雙源雙能CT(DSDECT)虛擬去鈣(VNCa)骨髓成像在多發(fā)性骨髓瘤(MM)彌漫浸潤性病變評價中的應(yīng)用價值。方法以2015年12月至2016年6月在北京協(xié)和醫(yī)院就診的31例漿細胞病患者為研究對象,行全身第3代DSDECT和全身MRI檢查。在VNCa及常規(guī)CT圖像測定椎體CT值,評價椎體VNCa CT值與MRI信號強度相關(guān)性。以MRI為參考標準,評價VNCa對MM彌漫浸潤病變的診斷力。結(jié)果 MM彌漫浸潤椎體組(n=62)VNCa的平均CT值為(-13.27±18.96)HU,明顯高于非彌漫浸潤椎體組(n=117)的(-63.31±26.75)HU,(Z=-9.731,P=0.000)。椎體VNCa CT值與T1 WI序列椎體和無退變椎間盤信號強度比值呈顯著負相關(guān)(rs=-0.592,P=0.000)。VNCa診斷MM彌漫浸潤病變的受試者工作曲線下面積為0.943;VNCa CT值-37 HU時的敏感性為90.32%,特異性為87.18%。結(jié)論第3代DSDECT VNCa骨髓成像具有診斷MM彌漫浸潤病變的能力。
[Abstract]:Objective to evaluate the value of the third generation dual energy CTD DSDECT virtual decalcification (VN Ca) bone marrow imaging in the evaluation of diffuse infiltrative lesions of multiple myeloma (MM). Methods from December 2015 to June 2016, 31 patients with plasmacytosis were examined by DSDECT and MRI. The CT value of vertebral body was measured by VNCa and conventional CT images, and the correlation between VNCa CT value and MRI signal intensity was evaluated. Using MRI as the reference standard, the diagnostic power of VNCa for diffuse infiltrative lesions of MM was evaluated. Results the average CT value of VNCa in the diffuse infiltrating vertebral body group was -13.27 鹵18.96 Hu, which was significantly higher than that in the non-diffuse infiltrating vertebral body group (-63.31 鹵26.75). There was a significant negative correlation between CT value of vertebral body and signal intensity ratio of vertebral body and nondegenerative intervertebral disc on T 1WI sequence. The sensitivity was 90.32 and the specificity was 87.18 when the area under the operating curve was 0.943 and the area under the operating curve was -37 Hu. Conclusion the third generation DSDECT VNCa bone marrow imaging has the ability to diagnose diffuse infiltrative lesions of MM.
【作者單位】： 中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院北京協(xié)和醫(yī)院放射科;中日友好醫(yī)院放射科;中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院北京協(xié)和醫(yī)院血液科;
【基金】：國家臨床重點�？平ㄔO(shè)項目(2014) 衛(wèi)生公益性行業(yè)科研專項項目(201402019)~~
【分類號】：R733.3;R730.44

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