本文選題：椎間盤(pán) + 磁共振成像　； 參考：《中國(guó)組織工程研究》2017年03期

【摘要】：背景:靈長(zhǎng)類(lèi)動(dòng)物猴被認(rèn)為是模擬人類(lèi)椎間盤(pán)退變的最佳動(dòng)物,但有關(guān)猴腰椎間盤(pán)退變規(guī)律的研究極少。目的:通過(guò)磁共振T2mapping和T1ρ成像技術(shù)探討群養(yǎng)種屬成年恒河猴腰椎間盤(pán)退變過(guò)程及其退變特點(diǎn)。方法:在1.5T MR掃描儀上采集符合研究條件的63只群養(yǎng)種屬恒河猴腰椎間盤(pán)矢狀位的T2WI、T2 mapping和T1ρ圖像,利用后處理工作站測(cè)定腰椎間盤(pán)髓核組織感興趣區(qū)的T2-map值和T1ρ值。結(jié)果與結(jié)論:(1)研究獲得425個(gè)質(zhì)量良好的成年恒河猴腰椎間盤(pán)磁共振圖像,不同人員對(duì)髓核組織T2-map值和T1ρ值的測(cè)量高度一致,兩者Kappa系數(shù)達(dá)0.93以上;(2)恒河猴腰椎間盤(pán)髓核組織T1ρ值和T2-map值與Pfirrmann分級(jí)呈顯著負(fù)相關(guān)(r=-0.842,P0.01;r=-0.896,P0.01)。PfirrmannⅠ-Ⅳ級(jí)之間恒河猴腰椎間盤(pán)髓核組織T1ρ值和T2-map值差異均有顯著性意義(P0.001,P0.001)。PfirrmannⅡ-Ⅲ級(jí)(退變?cè)缙?和PfirrmannⅣ-Ⅴ級(jí)(退變晚期)的髓核組織T1ρ值與Pfirrmann分級(jí)呈顯著負(fù)相關(guān)(r=-0.517,P0.01;r=-0.499,P0.01);退變?cè)缙诤屯俗兺砥诘乃韬私M織T2-map值與Pfirrmann分級(jí)也呈顯著負(fù)相關(guān)(r=-0.617,P0.01;r=-0.652,P0.01);(3)L_(1-2)和L_(2-3)椎間盤(pán)髓核組織T2-map值明顯低于L_(6-7)和L_7-S_1椎間盤(pán)髓核組織T2-map值(P0.05);(4)不同年齡段恒河猴腰椎間盤(pán)髓核組織T2-map值和T1ρ值差異有顯著性意義(r=-0.730,P0.001;r=-0.702,P0.001);(5)結(jié)果說(shuō)明,磁共振T2 mapping和T1ρ成像技術(shù)可客觀量化敏感地評(píng)估恒河猴腰椎間盤(pán)髓核組織的退變過(guò)程;成年恒河猴L(fēng)1-2和L_(2-3)椎間盤(pán)較L_(6-7)和L_7-S_1椎間盤(pán)易發(fā)生退變且退變程度重;年齡是影響成年恒河猴腰椎間盤(pán)退變的重要因素之一。
[Abstract]:Background: primate monkeys are considered to be the best animals to mimic the degeneration of human intervertebral disc. Objective: to investigate the process and characteristics of lumbar disc degeneration in adult rhesus monkeys by magnetic resonance T2mapping and T 1 蟻 imaging. Methods: the T _ 2W _ I _ T _ 2 mapping and T _ 1 蟻 images of the sagittal position of lumbar intervertebral disc of 63 rhesus monkeys were collected by 1.5T Mr scanner. The T2-map value and T1 蟻 value of the area of interest in the nucleus pulposus of lumbar intervertebral disc were measured by post-processing workstation. The results were in good agreement with the T2-map and T1 蟻 values of nucleus pulposus in 425 adult rhesus monkeys. There was a significant negative correlation between T1 蟻 and T2-map in the nucleus pulposus of the lumbar intervertebral disc of rhesus monkey and Pfirrmann grade. There were significant differences between T1 蟻 and T2-map in the nucleus pulposus of rhesus monkey in grade 鈪，

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