本文選題：乳腺超聲 + PD-　； 參考：《基因組學(xué)與應(yīng)用生物學(xué)》2017年08期

【摘要】：為探討B(tài)I-RADS分級聯(lián)合PD-1在乳腺癌患者中的診斷效果,本研究選取在2016年1月至2017年1月就診于我院超聲科的153例乳腺腫瘤患者作為研究對象。本研究于治療前采集患者外周血,使用熒光定量PCR技術(shù)進(jìn)行PD-1 m RNA檢測,并以20例年齡、性別相匹配的健康人作為對照。采用x2檢驗(yàn)或Fisher精確檢驗(yàn)分析乳腺癌患者臨床病理信息與BI-RADS和PD-1 m RNA的關(guān)系,使用ROC曲線評價(jià)乳腺超聲BI-RADS分級、PD-1 m RNA表達(dá)及兩者聯(lián)合的診斷價(jià)值。數(shù)據(jù)顯示,乳腺超聲BI-RADS分級診斷的靈敏度為89%、特異度為74%、曲線下面積為0.888(p0.001);PD-1 m RNA表達(dá)診斷靈敏度為78%、特異度為77%、曲線下面積為0.826(p0.001);兩者聯(lián)合診斷的靈敏度為91%、特異度為87%、曲線下面積為0.918(p0.001)。乳腺癌患者中,腫瘤越大、分期越晚的患者BI-RADS分級越高;孕激素受體陽性患者PD-1 m RNA表達(dá)升高。本研究表明,乳腺超聲BI-RADS分級聯(lián)合PD-1檢測的診斷價(jià)值優(yōu)于兩者單獨(dú)的診斷價(jià)值,能成為診斷乳腺癌的一種有效方法,值得在臨床上推廣使用。
[Abstract]:In order to investigate the diagnostic effect of BI-RADS grading combined with PD-1 in breast cancer patients, 153 cases of breast tumors in our hospital from January 2016 to January 2017 were selected as the subjects. This study collected peripheral blood before treatment and used fluorescence quantitative PCR technique to detect PD-1 m RNA, and 20 cases of age and sex. The relationship between the clinicopathological information of breast cancer patients and BI-RADS and PD-1 m RNA was analyzed by x2 test or Fisher accurate test. The ROC curve was used to evaluate the breast ultrasound BI-RADS grading, PD-1 m RNA expression and the combination of the two diagnostic values. The data showed that the sensitivity of the breast ultrasound BI-RADS grading diagnosis was 89%, The specificity was 74%, the area under the curve was 0.888 (p0.001); the diagnostic sensitivity of the PD-1 m RNA expression was 78%, the specificity was 77%, and the area under the curve was 0.826 (p0.001); the sensitivity of the combined diagnosis was 91%, the specificity was 87%, and the area under the curve was 0.918 (p0.001). The greater the tumor, the higher the tumor, the higher the BI-RADS classification of the patients with the later stages; the pregnancy excitement of the patients. The expression of PD-1 m RNA in the patients with positive hormone receptor is higher. This study shows that the diagnostic value of breast ultrasound BI-RADS classification combined with PD-1 detection is superior to the diagnostic value of both alone. It can be an effective method for the diagnosis of breast cancer and is worth popularizing in clinical practice.

【作者單位】： 河北省滄州市中心醫(yī)院超聲科;
【基金】：河北省滄州市中心醫(yī)院資助
【分類號】：R445.1;R737.9
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本文編號：1773637