本文選題：遺傳性痙攣性截癱 + 磁共振成像��； 參考：《青島大學(xué)》2014年碩士論文

【摘要】：目的討論SPG6型遺傳性痙攣性截癱(HSP)患者的顱腦核磁共振成像的表現(xiàn)特點(diǎn),進(jìn)一步提高對該病的認(rèn)知與了解。 資料與方法分析12例已基因診斷為SPG6型HSP患者的顱腦MRI表現(xiàn),并在TIWI的正中矢狀位層面測量胼胝體膝部寬度、胼胝體體部寬度、胼胝體壓部的寬度、胼胝體的面積和腦內(nèi)大腦的面積。另選取400例在同一臺磁共振機(jī)上行顱腦磁共振成像檢查的患者作為對照組,測量方法同病例組。分別計算病例組與對照組胼胝體膝部寬度、胼胝體壓部寬度、胼胝體體部寬度、胼胝體各部寬度之和、胼胝體面積、腦內(nèi)大腦面積及胼腦比值的均值,最終將二者的均值進(jìn)行比較。 結(jié)果2例HSP患者顱腦MRI未見明顯異常。10例HSP患者出現(xiàn)不同程度、不同部位胼胝體變薄及腦萎縮表現(xiàn),其中6例伴有雙側(cè)半卵圓中心和(或)放射冠區(qū)出現(xiàn)異常高信號,還有1例年長者右側(cè)頂葉顯示異常高信號。胼胝體膝部寬度、胼胝體壓部寬度、胼胝體體部寬度、胼腦比值的均值患者組小于對照組,差異均有統(tǒng)計學(xué)意義(P005)。 結(jié)論SPG6型HSP患者的顱腦MRI可以表現(xiàn)出胼胝體變薄、腦萎縮、雙側(cè)半卵圓中心或放射冠區(qū)異常高信號的特點(diǎn)。單純型HSP患者和復(fù)雜型HSP患者的顱腦MRI可能具有相似的特點(diǎn)。
[Abstract]:Objective to discuss the features of craniocerebral magnetic resonance imaging (MRI) in patients with SPG6 type hereditary spastic paraplegia.Materials and methods the craniocerebral MRI findings of 12 patients with SPG6 type HSP diagnosed by gene were analyzed. The width of the knee part of the corpus callosum, the width of the corpus callosum and the width of the splenium of the corpus callosum were measured on the median sagittal plane of TIWI.The area of the corpus callosum and the area of the brain.In addition, 400 patients were selected as control group who were examined by uplink craniocerebral magnetic resonance imaging on the same magnetic resonance machine.The genu width of corpus callosum, the width of corpus callosum, the width of corpus callosum, the total width of corpus callosum, the area of corpus callosum, the area of brain and the ratio of callosal brain were calculated.Finally, the average value of the two is compared.Results there were no obvious abnormalities in craniocerebral MRI in 2 cases of HSP. 10 cases of HSP showed different degrees of thinning of corpus callosum and brain atrophy in different parts. Among them, 6 cases were accompanied by abnormal high signal intensity in bilateral semicircular center and / or radiation-coronal area.Another patient showed abnormal hyperintensity in the right parietal lobe.The genu width of the corpus callosum, the width of the corpus callosum, the width of the corpus callosum and the ratio of callosal brain in the patients group were smaller than those in the control group (P 0.05).Conclusion craniocerebral MRI in patients with SPG6 type HSP can be characterized by thinning of corpus callosum, atrophy of brain, abnormal hyperintensity of bilateral semicircular center or radio-coronal area.Craniocerebral MRI may have similar characteristics in patients with simple HSP and complex HSP.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R682.22;R445.2

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