本文選題：輻射　切入點：骨髓　出處：《放射學實踐》2015年05期

【摘要】：目的:采用動態(tài)增強MRI(DCE-MRI)定量滲透性參數(shù)探索X線照射后大鼠股骨骨髓微血管滲透性變化。方法:36只6-8周齡SD大鼠隨機分為輻射組(n=18)和對照組(n=18),輻射組大鼠接受6.0Gy高能量X線全身照射,對照組大鼠不進行照射處理。分別在X線照射前后各時間點行股骨DCE-MRI灌注成像檢查,測量股骨興趣區(qū)微血管轉(zhuǎn)運常數(shù)(Ktrans)、反流速率常數(shù)(Kep)、血漿容積分數(shù)(Vp)和血管外細胞外容積分數(shù)(Ve);大鼠股骨行組織病理學檢查并測定微血管密度(MVD)。結(jié)果:輻射組在輻射前后各時間點DCE-MRI灌注參數(shù)Ktrans、Kep、Vp、Ve值差異均具有統(tǒng)計學意義(F=59.097,P0.01;F=21.349,P0.01;F=27.059,P0.01;F=32.061,P0.01)。Ktrans值逐漸增加,在輻射后第7天達到峰值;Vp值逐漸減小;Kep值照射后第4天減小(P0.01),第7天較第4天增大(P0.01);Ve值照射后第4天增大(P0.01),第7天與第4天無明顯變化(P0.05)。相應時間節(jié)點對照組各滲透性參數(shù)之間差異無統(tǒng)計學意義(P值均0.05)。輻射組大鼠MVD與Ktrans、Kep值呈負相關(guān)(r值分別為-0.5936、-0.8055,P值均0.05)、與Vp呈正相關(guān)(r=0.6451,P0.05)、與Ve值無相關(guān)性(r=0.1426,P0.05)。結(jié)論:DCE-MRI定量參數(shù)可評價早期放射性骨髓損傷的微血管滲透性變化。
[Abstract]:Aim: to explore the changes of microvascular permeability of femur bone marrow in rats after X-ray irradiation by dynamic enhanced MRI DCE-MRI quantitative permeability parameters.Methods Thirty-six Sprague-Dawley rats aged 6-8 weeks were randomly divided into radiation group (n = 18) and control group (n = 18). Rats in radiation group received 6.0Gy high energy X-ray whole body irradiation, while rats in control group were not treated by irradiation.Femoral DCE-MRI perfusion imaging was performed at different time points before and after X-ray irradiation.The microvascular transport constants of the area of interest to the femur (KtransA), the reflux rate constant (Kepa), the plasma volume fraction (VP) and the extracellular volume fraction (Veg) were measured, and the histopathological examination and microvessel density (MVD) were performed in the femur of rats.Results: there were significant differences in the DCE-MRI perfusion parameters (KT, KepP, VpV, ve) between the radiation group and the control group (P = 59.097, P 0.01, P = 21.349A, P 0.01F = 27.059C, P 0.01F = 32.061g, P 0.01N, P 0.01N, P 0.01a), and the value of Ktrans increased gradually in the radiation group at different time points before and after radiation.On the 7th day after irradiation, the peak value of Vp decreased gradually, and the value of Kep decreased gradually on the 4th day after irradiation, and on the 7th day compared with the 4th day, the value of P0.01V value increased, and the value of P0.01U increased on the 4th day after irradiation, and there was no significant change in P0.05 on the 7th and 4th day.There was no significant difference in the permeability parameters between the control group and the control group at the corresponding time points (P = 0.05).In the radiation group, the values of MVD and KTranskep were negatively correlated (r = -0.5936) -0.8055 (P = 0.05), and positively correlated with VP (r = 0.6451p 0.05), but not correlated with the value of ve (n = 0.1426) (P 0.05).Conclusion the microvascular permeability of early radiation bone marrow injury can be evaluated by the quantitative parameters of the weight DCE-MRI.
【作者單位】： 武漢大學人民醫(yī)院放射科;
【基金】：湖北省自然科學基金資助項目(2013CFB242) 湖北省衛(wèi)生廳科研資助項目(JX6B68)
【分類號】：R818;R445.2

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