本文選題：泡狀棘球蚴　切入點(diǎn)：肝　出處：《中國(guó)介入影像與治療學(xué)》2017年09期

【摘要】：目的探討CEUS評(píng)價(jià)不同時(shí)期大鼠肝泡狀棘球蚴病(HAE)血流灌注的價(jià)值。方法采用CEUS觀察70只成功感染HAE的大鼠在接種后不同時(shí)期(9、28、50周)的血流灌注特征,并與病理結(jié)果對(duì)照。結(jié)果接種9周時(shí)55個(gè)(55/70,78.57%)病灶表現(xiàn)為高回聲,15個(gè)(15/70,21.43%)病灶表現(xiàn)為混合性回聲,病理表現(xiàn)為乳白色單/多囊泡樣結(jié)構(gòu)。隨接種時(shí)間的延長(zhǎng)(28、50周),病灶最大徑逐漸增大,病灶內(nèi)部實(shí)性成分及鈣化灶逐漸增多,部分病灶可出現(xiàn)液化壞死。鏡下病灶周邊纖維組織逐漸增厚,周邊見(jiàn)微血管聚集區(qū)。接種9周時(shí)CEUS顯示病灶呈環(huán)狀強(qiáng)化及分隔樣強(qiáng)化,28周及50周時(shí)呈環(huán)狀強(qiáng)化或伴細(xì)線樣強(qiáng)化及無(wú)強(qiáng)化。CEUS后病灶邊緣增強(qiáng)帶最大寬度與病灶最大徑比值隨接種時(shí)間延長(zhǎng)而逐漸減小(P=0.02)。結(jié)論接種后不同時(shí)期大鼠HAE病灶的超聲征象漸趨復(fù)雜,壞死區(qū)及鈣化灶增加,CEUS可顯示不同時(shí)期病灶周邊及內(nèi)部的血流灌注特征。
[Abstract]:Objective to evaluate the value of CEUS in evaluating the perfusion of hepatic alveolar echinococcosis (HAE) in rats at different stages. Methods CEUS was used to observe the blood perfusion characteristics of 70 rats successfully infected with HAE at different stages (2850 weeks after inoculation). Results at 9 weeks after inoculation, 55 lesions showed hyperechoic and 15 / 15 / 70 / 70 / 21.43) lesions showed mixed echo, and 55 / 55 / 70 / 78.57) lesions showed hyperechoic, and 15 / 15 / 70 / 70 / 21.43) lesions showed mixed echo. With the extension of inoculation time of 2850 weeks, the maximum diameter of the lesion gradually increased, and the solid composition and calcification of the lesion increased gradually. Liquefaction necrosis may occur in some lesions. The fibrous tissue around the lesion is gradually thickened under microscope. Peripheral microvascular agglomeration. At 9 weeks of inoculation, CEUS showed the lesion as annular enhancement and septoid enhancement at 28 weeks and 50 weeks with ring enhancement or thin line enhancement and no enhancement. CEUS showed the maximum width of the margin enhancement zone and the maximum lesion size after inoculation. The ratio of large diameter to diameter decreased gradually with the time of inoculation. Conclusion the ultrasonic signs of HAE lesions become more and more complicated in different periods after inoculation. Enhanced CEUs in necrotic areas and calcified foci could display the perfusion characteristics around and inside the lesions at different stages.
【作者單位】： 新疆醫(yī)科大學(xué)第一附屬醫(yī)院超聲診斷科;新疆醫(yī)科大學(xué)第一附屬醫(yī)院新疆包蟲(chóng)病基礎(chǔ)醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室;新疆醫(yī)科大學(xué)第一附屬醫(yī)院影像中心;
【基金】：國(guó)家自然科學(xué)基金(81460267)
【分類號(hào)】：R445.1;R532.3
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本文編號(hào)：1658175