本文選題：超聲造影　切入點：肝臟局灶性病變　出處：《廣西醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討超聲造影參數(shù)成像在肝臟局灶性病變診斷中的應(yīng)用研究。 方法：運用SonoLiverCAP軟件對88例接受超聲造影檢查的肝臟局灶性病變患者病灶進(jìn)行定量分析,并以病灶與周圍肝實質(zhì)的增強(qiáng)水平差值為參數(shù)進(jìn)行動態(tài)血管模型(dynamicvascularpatterns,DVP)參數(shù)成像,比較良、惡性組間及其與周圍肝實質(zhì)定量參數(shù)及DVP有無差異。 結(jié)果：定量參數(shù)包括:峰值強(qiáng)度、上升時間、達(dá)峰時間、平均渡越時間、灌注指數(shù)、上升斜率、下降斜率、峰值強(qiáng)度完全下降時間。我們把上升時間、達(dá)峰時間、灌注指數(shù)、上升斜率定義為灌注參數(shù);平均渡越時間、下降斜率、峰值強(qiáng)度完全下降時間定義為消退參數(shù)。良、惡性組間峰值強(qiáng)度比較差異無統(tǒng)計學(xué)意義(P=0.121);良、惡性組間灌注參數(shù)及消退參數(shù)比較差異均有統(tǒng)計學(xué)意義(P0.05)。在良性組中,峰值強(qiáng)度及灌注參數(shù)(除上升時間)與周圍肝實質(zhì)比較差異有統(tǒng)計學(xué)意義(P0.05);而上升時間及消退參數(shù)與周圍肝實質(zhì)比較差異無統(tǒng)計學(xué)意義(P0.05)。在惡性組中,灌注參數(shù)及消退參數(shù)與周圍肝實質(zhì)比較差異均有統(tǒng)計學(xué)意義(P0.05)。在DVP曲線圖中,良、惡性組消退型、未消退型及負(fù)向型分別占10%(4/40)、72.5%(29/40)、17.5%(7/40)和87.5%(42/48)、10.4%(5/48)、2.1%(1/48),兩組比較差異有統(tǒng)計學(xué)意義(P0.01);在DVP分布圖中,良、惡性組消退型、未消退型及負(fù)向型分別占10%(4/40)、72.5%(29/40)、17.5%(7/40)和89.6%(43/48)、8.3%(4/48)、2.1%(1/48),兩組比較差異有統(tǒng)計學(xué)意義(P0.01)。 結(jié)論：超聲造影參數(shù)成像可以更直觀清晰地反映肝臟良惡性病灶與周圍肝實質(zhì)增強(qiáng)及消退水平的動態(tài)變化。
[Abstract]:Objective: to investigate the application of contrast-enhanced parametric imaging in the diagnosis of focal liver lesions. Methods: SonoLiverCAP software was used to quantitatively analyze the lesions of 88 patients with focal hepatic lesions undergoing contrast-enhanced ultrasonography. The dynamic vascular model of dynamic vasculature pattern patterns (DVPs) was performed by using the enhancement level difference between the lesions and the surrounding hepatic parenchyma as parameters. The quantitative parameters of liver parenchyma and DVP were different between malignant groups and peripheral liver parenchyma. Results: quantitative parameters include: peak intensity, rise time, peak time, average transit time, perfusion index, rise slope, descent slope, peak intensity complete decline time. The ascending slope is defined as the perfusion parameter, the mean transit time, the descent slope and the peak intensity fall time are defined as the regression parameters. There is no significant difference in peak intensity between benign and malignant groups (P < 0. 121). There were significant differences in perfusion parameters and regression parameters among malignant groups (P 0.05). The peak intensity and perfusion parameters (except rising time) were significantly different from those of peripheral hepatic parenchyma (P 0.05), but there was no significant difference between the rising time and regression parameters compared with that of peripheral liver parenchyma (P 0.05). There were significant differences in perfusion parameters and regression parameters between the surrounding liver parenchyma and the surrounding liver parenchyma (P 0.05). In the DVP curve, the regression, non-regression and negative types of benign and malignant groups accounted for 10.4 / 40 / 72.529 / 72.5 / 740 / 740 / 740 and 87.55 / 448 / 10.4 / 548 / 1 / 1 / 48, respectively. The difference between the two groups was statistically significant (P10.010); in the distribution of DVP, there was a significant difference between the two groups. In benign and malignant groups, regression type, unabated type and negative type accounted for 10 / 4 / 40 / 72.5 / 29 / 40 / 75 / 740) and 89.6 / 43 / 48 / 8 / 8 / 2. 1 / 1 / 48, respectively. There was a significant difference between the two groups (P0.01 / 0. 01, P < 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01). Conclusion: the dynamic changes of enhancement and regression of benign and malignant liver lesions and surrounding hepatic parenchyma can be more clearly reflected by contrast-enhanced parameter imaging.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R445.1;R735.7

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