本文選題：磁共振成像　切入點：釓塞酸二鈉　出處：《中國醫(yī)學(xué)影像技術(shù)》2015年04期 　論文類型：期刊論文

【摘要】：目的探討釓塞酸二鈉(Gd-EOB-DTPA)肝膽期成像在慢性肝病背景下對肝癌檢出和定性的價值。方法回顧性分析99例慢性肝病患者的Gd-EOB-DTPA增強MRI表現(xiàn),89例患者經(jīng)臨床診斷或病理診斷有肝癌病灶,10例患者臨床診斷未見明確異常,作為陰性對照。所有MR圖像數(shù)據(jù),由2名高年資醫(yī)師共同閱片,分析肝膽期圖像與DWI對肝癌的檢出率;另由3名中低年資醫(yī)師將其分為有肝膽期組和無肝膽期組,并對兩組圖像獨立盲法閱片,比較兩組圖像肝癌病灶的檢出率、診斷信心分值及ROC曲線。組間結(jié)果的比較采用Wilcoxon或McNemar非參數(shù)檢驗。結(jié)果 89例肝癌患者共檢出130個病灶,其中肝癌病灶111個,良性結(jié)節(jié)19個,111個肝癌病灶中100個經(jīng)病理證實,11個臨床診斷。肝膽期成像對肝癌的檢出率高于DWI[99.10%(110/111)vs 90.99%(101/111),P=0.012];有肝膽期組閱片者平均信心分值明顯高于無肝膽期組(P=0.001);對于長徑≤1cm的小肝癌,有肝膽期組平均檢出率高于無肝膽期組[93.00%(17.67/19)vs 70.16%(13.33/19),P=0.016];有肝膽期組ROC曲線下面積亦高于無肝膽期組[0.949(95%CI:0.815~0.995)vs 0.744(95%CI:0.566~0.877),P=0.0023]。結(jié)論慢性肝病背景下應(yīng)用Gd-EOB-DTPA的肝膽期圖像的肝癌檢出率優(yōu)于DWI,尤其對于長徑≤1cm的小肝癌,同時能夠提高診斷信心。
[Abstract]:Objective to investigate the value of Gd-EOB-DTPA-Gd-EOB-DTPA in the detection and characterization of liver cancer in the background of chronic liver disease. Methods Gd-EOB-DTPA enhanced MRI findings of 99 patients with chronic liver disease were retrospectively analyzed. The clinical diagnosis of 10 patients with hepatocellular carcinoma was not clearly abnormal. As a negative control, all Mr image data were read by two senior medical practitioners to analyze the detection rate of hepatobiliary phase images and DWI, and 3 middle and middle aged doctors divided them into hepatobiliary phase group and non-hepatobiliary phase group, and 3 middle and middle aged doctors divided them into hepatobiliary phase group and non-hepatobiliary phase group. The detection rate, diagnostic confidence score and ROC curve of liver cancer were compared between the two groups. The results were compared by Wilcoxon or McNemar nonparametric test. Results 130 lesions were detected in 89 patients with liver cancer. Among them, 111 liver cancer lesions, The positive rate of hepatobiliary phase imaging in hepatocellular carcinoma was higher than that in DWI [99.10 / 111 vs 90.9910 / 111 / P 0.012]; the mean confidence score in patients with hepatobiliary phase was significantly higher than that in patients without hepatobiliary phase (P 0.001). Small hepatocellular carcinoma with diameter 鈮，

本文編號：1598411