本文關(guān)鍵詞： 乳腺腫瘤 超聲檢查 受體 雌激素 孕激素類 分子生物學(xué)指標(biāo)　出處：《中國(guó)全科醫(yī)學(xué)》2016年27期 　論文類型：期刊論文

【摘要】：背景乳腺癌的治療及預(yù)后與腫瘤的分子生物學(xué)指標(biāo)表達(dá)密切相關(guān)。目的探討乳腺浸潤(rùn)性導(dǎo)管癌直接超聲征象與分子生物學(xué)指標(biāo)雌激素受體(ER)、孕激素受體(PR)表達(dá)之間的關(guān)系。方法回顧性分析2014年12月—2015年4月首診于新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院并行手術(shù)的符合納入標(biāo)準(zhǔn)的109例乳腺浸潤(rùn)性導(dǎo)管癌患者的臨床資料。收集患者一般資料、免疫組化結(jié)果 (ER、PR表達(dá)情況)、超聲檢查結(jié)果 (病灶數(shù)量、病灶部位、病灶大小、分期、有無毛刺征、有無小分葉征、有無內(nèi)部微鈣化、有無后方回聲衰減、縱橫比、內(nèi)部血流Adler分級(jí))。結(jié)果 ER(+)75例(68.8%),PR(+)67例(61.5%),ER(-)34例(31.2%),PR(-)42例(38.5%)。單發(fā)病灶93例,多發(fā)病灶(病灶數(shù)量≥2個(gè))16例;右乳48例,左乳61例;病灶位于外上象限51例,病灶位于內(nèi)上象限27例,病灶位于外下象限16例,病灶位于內(nèi)下象限15例;病灶最大徑0.9~8.0 cm,平均病灶最大徑(2.8±1.4)cm;T1期28例,T2期62例,T3期19例,T4期0例。ER(-)+PR(-)與非〔ER(-)+PR(-)〕患者病灶最大徑比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。乳腺癌直接超聲征象中,內(nèi)部血流Adler分級(jí)Ⅱ~Ⅲ級(jí)90例(82.6%),小分葉征58例(53.2%),內(nèi)部微鈣化58例(53.2%),毛刺征49例(45.0%),后方回聲衰減49例(45.0%),縱橫比≥0.71 41例(37.6%)。毛刺征、小分葉征、內(nèi)部微鈣化、后方回聲衰減與ER、PR表達(dá)之間存在關(guān)聯(lián)性(P0.05);縱橫比、內(nèi)部血流Adler分級(jí)與ER、PR表達(dá)之間互相獨(dú)立(P0.05)。結(jié)論乳腺浸潤(rùn)性導(dǎo)管癌直接超聲征象與ER、PR的表達(dá)有一定相關(guān)性,超聲可以對(duì)乳腺癌進(jìn)行治療前評(píng)估及預(yù)后評(píng)價(jià)。
[Abstract]:Background the treatment and prognosis of breast cancer are closely related to the expression of molecular biological markers. Objective to investigate the expression of estrogen receptor ERA and progesterone receptor PRA in invasive ductal carcinoma of breast. Methods from December 2014 to April 2015, the clinical data of 109 breast invasive ductal carcinoma patients who were first diagnosed and operated at the affiliated Cancer Hospital of Xinjiang Medical University were analyzed retrospectively. The general data of the patients were collected. The results of immunohistochemistry were as follows: (number of lesions, location of lesions, size of lesions, stage, burr sign, small lobulation sign, internal microcalcification, back echo attenuation, aspect / aspect ratio), and the results of ultrasound examination (number of lesions, location of lesions, size of lesions, staging, no burr sign, internal microcalcification, posterior echo attenuation, ratio of aspect to aspect). Results Adler grading of internal blood flow was performed in 75 cases (68.8%). Results there were 34 cases (31.2%) with 31.2% PRA, 93 cases with single lesions, 16 cases with multiple lesions (the number of lesions 鈮，

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