【摘要】：microRNAs(miRNAs)是一種長(zhǎng)度為22nt的非編碼RNA分子,能夠結(jié)合mRNA,影響翻譯效率,調(diào)控蛋白的表達(dá)。近來(lái)多項(xiàng)研究表明,動(dòng)物宿主miRNAs通過(guò)多種機(jī)制抑制病毒的復(fù)制,如直接靶向病毒基因、干擾病毒復(fù)制所需因子、調(diào)節(jié)先天性免疫、調(diào)節(jié)細(xì)胞凋亡、調(diào)節(jié)細(xì)胞免疫,發(fā)揮抗病毒效應(yīng)。本文歸納總結(jié)宿主miRNAs對(duì)病毒復(fù)制的調(diào)控機(jī)制,討論miRNAs類(lèi)抗病毒藥物的應(yīng)用情況,并展望該類(lèi)藥物的發(fā)展趨勢(shì)。
[Abstract]:MicroRNAs (miRNAs) is a non-coding RNA molecule with length of 22nt, which can bind to mRNAs, affect translation efficiency and regulate the expression of proteins. A number of recent studies have shown that animal host miRNAs inhibits viral replication through a variety of mechanisms, such as direct targeting of virus genes, interfering with the factors required for viral replication, regulating innate immunity, regulating cell apoptosis, and regulating cellular immunity. Give play to the antiviral effect. In this paper, the mechanism of host miRNAs regulating virus replication is summarized, the application of miRNAs antiviral drugs is discussed, and the development trend of this kind of drugs is prospected.
【作者單位】： 中國(guó)動(dòng)物衛(wèi)生與流行病學(xué)中心外來(lái)病研究中心;青島市動(dòng)物疫病預(yù)防控制中心;
【基金】：“十三五”國(guó)家重點(diǎn)研發(fā)計(jì)劃(項(xiàng)目號(hào):2016YFD0500108),題目:小反芻獸疫病毒感染與免疫調(diào)控機(jī)制研究~~
【分類(lèi)號(hào)】：S852.65
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本文編號(hào)：2147107