本文選題：奶牛　切入點：氨基丁三醇PGFα注射液　出處：《中國獸醫(yī)學報》2017年05期 　論文類型：期刊論文

【摘要】：將18頭健康成年中國荷斯坦奶牛隨機分成高、中、低3組,每組每頭分別肌肉注射氨基丁三醇前列腺素F2α注射液10(50mg),5(25mg),2.5mL(12.5mg),采用酶聯(lián)免疫吸附法(ELISA)測定血藥濃度,用殘數(shù)法逐頭奶牛擬合藥動學曲線方程并計算藥動學參數(shù),研究氨基丁三醇前列腺素F2α在奶牛體內(nèi)的藥代動力學。結果表明,藥時數(shù)據(jù)符合有吸收一室模型,高,中,低組的主要藥動學參數(shù):吸收速率常數(shù)Ka分別為(18.22±2.17),(15.30±0.64),(20.09±5.03)h-1;吸收半衰期t1/2Ka分別為(0.04±0.004),(0.05±0.002),(0.04±0.01)h;分布和消除速率常數(shù)Ke分別為(1.32±0.14),(1.27±0.12),(1.40±0.16)h-1;消除半衰期t1/2Ke分別為(0.53±0.06),(0.55±0.05),(0.50±0.06)h;達峰時間tmax均為0.17h;達峰質(zhì)量濃度Cmax分別為(6.34±0.59),(5.94±0.27),(4.81±0.16)μg/L;藥時曲線下面積AUC0~t分別為(14.40±2.19),(10.14±1.07),(13.15±4.34)μg/(L·h)。奶牛單劑量肌肉注射氨基丁三醇前列腺素F2α注射液后,機體對藥物吸收迅速,消除快,濃度約10min達到峰值,100min后達到注射前的水平。根據(jù)藥時曲線峰濃度,AUC值及相關的臨床藥效學試驗結果,建議臨床使用劑量為5mL(25mg)。
[Abstract]:Eighteen healthy adult Chinese Holstein cows were randomly divided into 3 groups: high, middle and low. Each group was given intramuscular injection of ABA prostaglandin F _ 2 偽 injection 10 ~ 50 mg / L ~ 2.5 mL / L ~ 12.5 mg 路g ~ (-1) 路L ~ (-1) 路L ~ (2.5) mg 路L ~ (-1) ~ (-1) 路L ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1)). The pharmacokinetics of aminobutanol prostaglandin F 2 偽 in dairy cows was studied by fitting the pharmacokinetic curve equation and calculating the pharmacokinetic parameters with the residue method. The results showed that the pharmacokinetics of ABA prostaglandin F 2 偽 was consistent with the absorption one-compartment model. The main pharmacokinetic parameters of the low group were as follows: the absorption rate constant Ka was 18.22 鹵2.17, the absorption half-life t1/2Ka was 0.04 鹵0.004, the absorption rate constant K _ e was 1.32 鹵0.14 and 1.27 鹵0.12, respectively; the half-life t1/2Ke was 0.53 鹵0.06, 0.55 鹵0.06, respectively; the peak time was 0.17h. The Cmax was 6.34 鹵0.59 渭 g / L and the area under the curve was 10.14 鹵1.07 鹵1.07 渭 g / L, respectively. After single dose injection of prostaglandin F _ 2 偽, aminobutanol prostaglandin F _ 2 偽 was injected intramuscularly in dairy cows. The concentration of 10min reached the level before injection. According to the peak concentration of AUC and the results of clinical pharmacodynamics test, it was suggested that the clinical dosage should be 5 mL / L ~ 25 mg / g ~ (-1) ~ (-1) 路min ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (-1)).
【作者單位】： 西北農(nóng)林科技大學動物醫(yī)學學院;
【基金】：西北農(nóng)林科技大學國家級“大學生創(chuàng)新創(chuàng)業(yè)訓練計劃”項目(201510712023)
【分類號】：S859.793

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