本文關(guān)鍵詞： 板青顆粒 半數(shù)致死量(LD) 最大耐受量(MTD) 血常規(guī) 血液生化指標　出處：《黑龍江畜牧獸醫(yī)》2017年05期 　論文類型：期刊論文

【摘要】：為了評價板青顆粒的安全性,進行了小鼠的急性毒性試驗與大鼠的亞慢性毒性試驗,采用簡化機率單位法測得小鼠最大耐受量(MTD)高于180 g/(kg·d),半數(shù)致死量(LD50)無法確定。進行亞慢性試驗時將SD大鼠分為4組,每組20只,空白對照組飲服純凈水,板青顆粒低、中、高劑量組分別給予3,6,12 g/(kg·d)的板青顆粒于飲水中,連續(xù)28 d,分別檢測體重、臟器指數(shù)、血常規(guī)指標、血液生化指標和組織切片觀察。結(jié)果表明:與空白對照組比較,板青顆粒顯著提高大鼠的脾臟指數(shù)(P0.05)、中性粒細胞百分比(Gran%)、血細胞比容(HCT)、紅細胞體積分布寬度(RDW)(P0.05),顯著降低胸腺指數(shù)、淋巴細胞百分比(Lymph%)、細胞血紅蛋白濃度(MCHC)以及總蛋白(TP)、葡萄糖(GLU)、尿素氮(BUN)含量(P0.05);心臟、肝臟、脾臟、肺臟、腎臟組織切片無顯著性病理變化。說明板青顆粒毒副作用和不良反應小,是安全性較高的中藥方劑。
[Abstract]:In order to evaluate the safety of Banqing granules, acute toxicity test in mice and subchronic toxicity test in rats were carried out. The maximum tolerance dose (MTD) of mice measured by simplified probabilistic unit method was higher than 180 g / kg 路d). SD rats were divided into 4 groups with 20 rats in each group. The blank control group was treated with pure water, Banqing granules were low, medium and high dose groups were given 3 respectively. The body weight, organ index and blood routine were measured for 28 days. The results showed that compared with the blank control group, Banqing granule significantly increased the spleen index (P 0.05) and the percentage of neutrophils (P 0.05). HCT, RDWV, P0.05, decreased the thymus index significantly, and the percentage of lymphocytes was lower than that of Lymphoma). Cell hemoglobin concentration (MCHCC), total protein (TPN), glucose gluconium (GLU), urea nitrogen bun (bun) content (P0. 05%); There were no significant pathological changes in heart, liver, spleen, lung and kidney tissue sections.
【作者單位】： 河北農(nóng)業(yè)大學中獸醫(yī)學院;保定市農(nóng)業(yè)局;
【基金】：中華人民共和國獸藥典委員會項目
【分類號】：S853.7
【正文快照】： 板青顆粒是《中華人民共和國獸藥典》(2010版)收錄的常用中藥方劑,由板藍根600 g和大青葉900 g經(jīng)提取制成顆粒劑,具有清熱解毒、涼血等功效,用于治療和預防如風熱感冒、咽喉腫痛、熱病發(fā)斑等溫熱性畜禽疾病。板藍根為十字花科植物菘藍的干燥根入藥,功效為清火解毒,涼血止血,治，

本文編號：1471754