Fibroblast growth factor（FGF）/fibroblast growth factor receptor（FGFR） signaling plays essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs in humans can cause various congenital bone diseases, including chondrodysplasia syndromes, craniosynostosis syndromes and syndromes with dysregulated phosphate metabolism. FGF/FGFR signaling is also an important pathway involved in the maintenance of adult bone homeostasis. Multiple kinds of mouse models, mimicking human ske... 

【文章來源】：Bone Research. 2014,2(01)

【文章頁(yè)數(shù)】：24 頁(yè)

【文章目錄】：
INTRODUCTION
ROLE OF FGFRS IN BONE GENETIC DISEASES AND HOMEOSTASIS
    FGFR1
    FGFR2
    FGFR3
    FGFR4
FGFS PARTICIPATE IN SKELETON DEVELOPMENT AND BONE METABOLISM
    FGF2
    FGF4
    FGF8
    FGF9
    FGF10
    FGF18
    FGF21
    FGF23
OTHER FGFS
CONCLUSIONS
Conflict of Interest


【參考文獻(xiàn)】：
期刊論文
[1]Fgfr3基因374點(diǎn)突變致軟骨發(fā)育不全小鼠模型的建立與分析[J]. 王建民,杜曉蘭,李翠玲,尹良軍,陳波,孫晶,蘇楠,趙玲,宋瑞華,宋維威,陳林,鄧初夏.  中華醫(yī)學(xué)遺傳學(xué)雜志. 2004(06)



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