【摘要】：背景:炎癥牙髓干細胞是近年來新發(fā)現(xiàn)的一類牙髓干細胞,目前尚無對其研究進展的系統(tǒng)評價。目的:系統(tǒng)評價炎癥牙髓干細胞的研究進展。方法:以"(Pulptis OR Inflam*Dental Pulp*OR Human Dental Pulp with Irreversible Pulpitis)AND Stem Cell*/(牙髓炎OR炎癥牙髓OR不可逆性牙髓炎)AND干細胞"為檢索詞檢索PubMed、Web of Science、CNKI、WanFang及VIP數據庫(時間:建庫至2014年2月),同時手檢納入研究的參考文獻。對研究結果進行定性分析,進行炎癥牙髓干細胞研究進展的全面總結。結果與結論:共納入11篇文獻進行研究,全面闡述炎癥牙髓干細胞的研究歷史、材料來源、細胞培養(yǎng)、表面標志、擴增能力、多向分化能力、動物模型及臨床應用前景的研究進展。炎癥牙髓干細胞研究尚處于起步,培養(yǎng)條件和動物模型的建立正處于探究階段,擴增能力和多向分化能力研究結果尚有爭議,而在免疫特性、亞群研究和臨床應用方面研究較少。
[Abstract]:Background: inflammatory dental pulp stem cells are a kind of newly discovered dental pulp stem cells in recent years, and there is no systematic evaluation of their research progress. Objective: to systematically evaluate the research progress of inflammatory dental pulp stem cells. Methods: "(Pulptis OR Inflam*Dental Pulp*OR Human Dental Pulp with Irreversible Pulpitis) AND Stem Cell*/ (pulpitis OR inflammatory OR irreversible pulpitis) AND stem cells" were used as search words to search PubMed,Web of Science,CNKI,WanFang and VIP database (time: from establishment to February 2014). At the same time, hand examination was included in the references of the study. The research results were qualitatively analyzed and the research progress of inflammatory dental pulp stem cells was summarized. Results and conclusion: a total of 11 literatures were included to review the research history, material source, cell culture, surface marker, amplification ability, multidirectional differentiation ability, animal model and clinical application prospect of inflammatory dental pulp stem cells. The study of inflammatory dental pulp stem cells is still in its infancy, and the establishment of culture conditions and animal models is in the exploratory stage. The results of amplification and multidirectional differentiation are controversial, but there are few studies on immune characteristics, subgroup research and clinical application.
【作者單位】： 西安交通大學口腔醫(yī)院;西安交通大學口腔醫(yī)院牙周黏膜科;西安交通大學口腔醫(yī)院中心實驗室;
【基金】：西安交通大學本科生科研訓練與實踐創(chuàng)新基金資助(2013289)~~
【分類號】：R329.2;R781.31

【參考文獻】

相關期刊論文 前2條

1 馮柳;遲路湘;;SDF-1促進BMSCs向血管內皮細胞分化[J];第三軍醫(yī)大學學報;2013年10期

2 霍永標;凌均h，

本文編號：2515891