發(fā)布時(shí)間：2019-04-02 20:12

【摘要】： 心率變異性分析作為一種無創(chuàng)性檢查自主神經(jīng)系統(tǒng)功能的方法,目前已經(jīng)被應(yīng)用于臨床。如:心血管系統(tǒng)疾病、糖尿病病情進(jìn)展和愈后的評估以及麻醉深度的監(jiān)測等等。然而在研究過程中,HRV頻譜分析中某些成分生理學(xué)意義尚未明確, HRV在探索疾病中自主神經(jīng)系統(tǒng)改變的作用如在自發(fā)性高血壓中的作用等等仍需進(jìn)一步的研究。這些研究許多數(shù)情況下需要基礎(chǔ)研究工作人員應(yīng)用動(dòng)物模型進(jìn)行長期的觀察和探討。因此,對實(shí)驗(yàn)動(dòng)物心電信號的記錄及心率變異分析系統(tǒng)十分必要。目前存在的心電信號的自動(dòng)分析系統(tǒng)市場價(jià)格多較高,而且多用于臨床研究。本實(shí)驗(yàn)設(shè)計(jì)以WINDOWS操作系統(tǒng)為平臺、應(yīng)用C語言研制開發(fā)一種應(yīng)用于對動(dòng)物心電信號中包含的心率變異信息的實(shí)時(shí)提取及分析系統(tǒng)。以利于對今后開展的HRV分析研究工作提供準(zhǔn)確的分析工具。并通過動(dòng)物實(shí)驗(yàn)對該程序進(jìn)行測試。本系統(tǒng)主要包括心電信號實(shí)時(shí)的采集模塊、心電信號保存模塊,HRV時(shí)域分析模塊(RR間期提取、RR間期直方圖、RR間期統(tǒng)計(jì)學(xué)分析),RR間期的Lorenz圖。頻域分析模塊(HRV的功率譜分析),并且通過對Wistar心肌缺血大鼠傾斜實(shí)驗(yàn)前后心電信號的記錄進(jìn)行心率變異性分析。經(jīng)測試,此系統(tǒng)完全可以滿足目前基礎(chǔ)實(shí)驗(yàn)中實(shí)驗(yàn)動(dòng)物的心電信號的提取及心率變異性分析的需要。
[Abstract]:Heart rate variability analysis (HRV), as a non-invasive method to examine autonomic nervous system function, has been used in clinical practice. For example: cardiovascular disease, diabetes progression and recovery assessment, as well as anesthesia depth monitoring and so on. However, the physiological significance of some components in HRV spectrum analysis is not clear. The role of HRV in exploring the changes of autonomic nervous system in diseases, such as the role in spontaneous hypertension and so on, needs to be further studied. Many of these studies require long-term observation and discussion by basic researchers using animal models. Therefore, it is necessary to record ECG signals and analyze heart rate variability in experimental animals. At present, the market price of ECG automatic analysis system is high, and most of them are used in clinical research. In this experiment, a real-time extraction and analysis system for heart rate variability contained in animal ECG signals was developed by using C language on the platform of WINDOWS operating system. In order to provide accurate analytical tools for the future work of HRV analysis. The program was tested by animal experiment. The system mainly includes ECG real-time acquisition module, ECG signal storage module, HRV time domain analysis module (RR interval extraction, RR interval histogram, RR interval statistical analysis of), RR interval Lorenz map). Frequency domain analysis module (HRV power spectrum analysis) and heart rate variability (HRV) were analyzed by recording ECG signals before and after tilting test in Wistar myocardial ischemia rats. The test results show that the system can fully meet the needs of ECG signal extraction and heart rate variability analysis of experimental animals in basic experiments.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R-331

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王守巖,張立藩,程九華,王興邦;頭高位傾斜實(shí)驗(yàn)心率變異性時(shí)頻動(dòng)態(tài)分析[J];第四軍醫(yī)大學(xué)學(xué)報(bào);2001年04期

2 景桂霞,朱耀民,葉平安;全麻復(fù)合硬膜外阻滯對腹部手術(shù)患者心率變異性的影響[J];第四軍醫(yī)大學(xué)學(xué)報(bào);2002年15期

3 李建軍;心率變異性在麻醉臨床應(yīng)用的進(jìn)展[J];國外醫(yī)學(xué).麻醉學(xué)與復(fù)蘇分冊;2000年06期

4 廖旺才，楊福生，胡廣書;心率變異性非線性信息處理的現(xiàn)狀與展望[J];國外醫(yī)學(xué).生物醫(yī)學(xué)工程分冊;1995年06期

5 孫京霞,白延強(qiáng);心率變異分析方法的研究進(jìn)展[J];航天醫(yī)學(xué)與醫(yī)學(xué)工程;2001年03期

6 李方潔,張平 ,劉艷 ,程英茜;Lorenz圖與心率變異分析[J];臨床心電學(xué)雜志;2004年01期

7 胡廣書,朱澤煌;心電圖的計(jì)算機(jī)輔助分析[J];上海生物醫(yī)學(xué)工程;1995年04期

8 沈霖霖,曹銀祥,吳國強(qiáng),李鵬;大鼠心率變異性頻譜中高頻成分的中樞機(jī)理分析[J];生理學(xué)報(bào);1998年04期

9 呂曉琪,蔣大宗;心率波動(dòng)信號的譜分析及其應(yīng)用[J];生物醫(yī)學(xué)工程學(xué)雜志;1993年03期

10 徐曉紅，羅勇，何偉，陳良遲，黃仲蓀，，謝正祥;計(jì)算機(jī)化大鼠心電信號采集和處理系統(tǒng)[J];生物醫(yī)學(xué)工程學(xué)雜志;1996年04期

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