【摘要】：目的:嚴重急性呼吸道綜合征(severe acute respiratorysyndrome, SARS)是一種急性呼吸道傳染病,亦稱為非典型肺炎。2002 年底,我國廣東省首先出現(xiàn)了有記錄SARS 病例,繼而在2003 年初傳播到世界30 多個國家,持續(xù)流行長達7個月,造成將近8100 人被感染,774 人死亡,死亡率超過9%。 SARS 的病原體已被確認為是一種新型冠狀病毒,稱為SARS 冠狀病毒(SRAS-CoV)。毫無疑問,SRAS-CoV 給大眾健康和社會經(jīng)濟造成了巨大的損失。雖然在SARS 第一次流行過后再罕有病例發(fā)生,但是,鑒于SARS 病毒具有多種傳播途徑和廣泛的包括一些野生動物在內的非人類中間宿主,SARS 很有可能在將來再次暴發(fā)。目前,我們還沒有針對SARS 的特效抗病毒藥物或者疫苗。為了預防和控制今后SARS 的流行,研制針對SARS 冠狀病毒的新型疫苗勢在必行。 SARS-CoV 是基因組全長約30Kb 的單股正鏈RNA 病毒,屬于冠狀病毒屬,和其他冠狀病毒類似, SARS的病毒RNA基因組有5 個開放讀碼框架(ORF)和9 個潛在的開放讀碼框架,這些開放讀碼框架編碼的蛋白包括RNA 聚合酶蛋白(polymerase protein)、刺突蛋白(spike protein, S)、小包膜蛋白(small membrane protein, E)、基質蛋白(matrix protein, M)和核衣殼蛋白(nucleocapsid protein, N)。在這些病毒蛋白中,
[Abstract]:Objective: severe acute respiratory syndrome (severe acute respiratorysyndrome, SARS) is an acute respiratory infectious disease, also known as atypical pneumonia. At the end of 2002, there were first recorded cases of SARS in Guangdong Province, China. The epidemic spread to more than 30 countries in the world in early 2003, lasting for seven months, leaving nearly 8100 people infected and 774 dead, with a mortality rate of more than 9 percent. The pathogen of SARS has been identified as a new type of coronavirus called SARS coronavirus (SRAS-CoV). There is no doubt that SRAS-CoV has caused enormous damage to public health and socio-economic. Although few cases have occurred after the first epidemic of SARS, SARS is likely to erupt again in the future, given that SARS has multiple transmission pathways and a wide range of non-human intermediate hosts, including some wild animals. At present, we do not have specific antiviral drugs or vaccines for SARS. In order to prevent and control the prevalence of SARS in the future, it is imperative to develop a new vaccine against SARS coronavirus. SARS-CoV is a single-stranded positive-stranded RNA virus with a total length of about 30Kb, belonging to the genus coronavirus, similar to other coronavirus. The RNA genome of SARS has five open reading frames (ORF) and nine potential open reading frames (ORF). These open reading frames encode proteins such as RNA polymerase protein (polymerase protein), spike protein (spike protein, S), small envelope protein (small membrane protein, E), matrix protein (matrix protein, M) and nucleocapsid protein (nucleocapsid protein, N). In these viral proteins,
【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：R392

【參考文獻】

相關期刊論文 前1條

1 ;DNA Vaccine of SARS-Cov S Gene Induces Antibody Response in Mice[J];Acta Biochimica et Biophysica Sinica;2004年01期

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