【摘要】：背景和目的：目前對全身性感染及炎性反應的認識已有很大提高，醫(yī)療技術及醫(yī)療設備也有了很大提高，但是在全世界范圍內，全身性感染(sepsis)仍是值得關注的問題：感染性休克的死亡率—這個重癥監(jiān)護病房最常見的死亡原因，并沒有顯著下降。約50％的全身性感染及感染性休克是革蘭陰性桿菌所致。越來越多的證據(jù)表明遺傳易感性與感染性疾病相關。遺傳流行病學研究表明遺傳因素對全身性感染的預后有重要影響。 基因的多態(tài)性即等位基因的變異，通常以一定頻率存在于人群中，但不能用新的突變來解釋(通常＞1％)。最常見的基因多態(tài)性是單核苷酸多態(tài)性(SNP)，，可以是替換、缺失或插入一個單核苷酸。人類DNA大約每300～500個堿基對就可能有一個SNP。變異的基因可以是在基因或啟動子區(qū)的編碼區(qū)(外顯子)，也可以是非編碼區(qū)(內含子)。當SNP發(fā)生在基因的蛋白編碼區(qū)，等位基因的變異可以導致氨基酸的替換，最終可引起蛋白功能的變化，使不同基因型患者的感染易感性有顯著差異。 脂多糖(LPS)是革蘭陰性菌細胞外壁的主要成份，可引發(fā)系統(tǒng)性炎性反應，最終可能導致全身性感染、感染性休克和器官衰竭。因此，研究LPS受體復合物基因多態(tài)性與感染易感性的關系有著重要的臨床意義。 目前已經(jīng)認識到基因多態(tài)性可以解釋為什么一小部分高危人群對抗生素無效或有藥物毒性反應。明確全身性感染反應中的基因成份，有助于在治療全身
[Abstract]:Background and objective: knowledge of systemic infection and inflammatory response has been greatly improved, medical technology and medical equipment have also been greatly improved, but worldwide, Systemic infection of (sepsis) remains a concern: the death rate from septic shock, the most common cause of death in intensive care units, has not declined significantly. About 50% of systemic infections and septic shock were caused by gram-negative bacilli. There is growing evidence that genetic predisposition is associated with infectious diseases. Genetic epidemiology has shown that genetic factors play an important role in the prognosis of systemic infection. The polymorphism of the gene is the variation of allele, which usually exists in the population at a certain frequency, but can not be explained by the new mutation (usually > 1%). The most common genetic polymorphisms are single nucleotide polymorphisms (SNP),) that can be replaced, deleted or inserted into a single nucleotide. Human DNA may have one SNP. for every 300-500 base pairs The mutated gene may be in the coding region (exon) or non-coding region (intron) of the gene or promoter. When SNP occurs in the protein coding region of the gene, allelic variation can lead to amino acid replacement, and eventually lead to the change of protein function, resulting in significant differences in susceptibility to infection in patients with different genotypes. Lipopolysaccharide (LPS) is the main component of the cell wall of gram-negative bacteria, which can induce systemic inflammatory reaction and may lead to systemic infection, septic shock and organ failure. Therefore, it is of great clinical significance to study the relationship between LPS receptor complex gene polymorphism and susceptibility to infection. Genetic polymorphisms have been recognized to explain why a small number of high-risk populations are ineffective or toxic to antibiotics. The identification of gene components in systemic infection response may be helpful in the treatment of systemic infection.
【學位授予單位】：第一軍醫(yī)大學
【學位級別】：碩士
【學位授予年份】：2006
【分類號】：R363

【引證文獻】

相關博士學位論文 前1條

1 趙一萍;蒙古馬免疫相關基因表達研究及脾臟表達譜分析[D];內蒙古農(nóng)業(yè)大學;2013年

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