【摘要】：目前,磁場生物效應是生物醫(yī)學工程學界的研究熱點。在兩次國家自然科學基金[①低強度脈沖電磁場治療心血管疾病的機理研究,50077023(2000年),負責人:羅二平;②低強度脈沖電磁場治療骨質疏松癥的機理研究,50377044(2003年),負責人:羅二平]的資助下,對磁場生物效應進行了較為深入系統(tǒng)地研究。本文首先評述了磁場生物效應的研究進展。通過動物模型的建立和體外細胞的培養(yǎng),進一步檢測生理、生化、免疫、生物力學等指標,以心血管疾病和骨質疏松癥為突破口,重點研究低強度脈沖磁場對機體的影響,探討磁場生物效應的產(chǎn)生機理,以期為心血管疾病及骨質疏松癥的預防和治療提供新的思路和理論依據(jù)。主要工作概括如下: 1.基于相干電振蕩理論、離子對膜的穿透理論和跨膜離子的回旋諧振理論等,對磁場非熱生物效應機理進行了分析研究。闡釋了磁場與生物系統(tǒng)之間相互作用的機理:①生物體對一定條件的磁場的響應是非線性的,并表現(xiàn)出頻率特異性和功率特異性——“窗口效應”;②指出生物體對極低頻(100 Hz)、低強度(100Gs)磁場非熱效應的應答優(yōu)于熱效應,低強度脈沖磁場容易導致機體內非熱生物累積效應的發(fā)生。 2.成功建立了高脂血癥、動脈粥樣硬化等心血管疾病動物模型和絕經(jīng)后骨質疏松動物模型,定量分析了血液流變學、血脂、心功能、骨形態(tài)計量學、骨密度、生化、免疫以及生物力學等指標,結合大體解剖學和組織病理學分析,通過對實驗整體方案的合理設計,體內與體外實驗相結合,系統(tǒng)研究研究了低強度脈沖磁場對心血管系統(tǒng)和骨骼系統(tǒng)的影響,探討了脈沖磁場生物效應的作用機理,為臨床上心血管疾病和骨質疏松癥的預防、治療提供了新的思路和理論依據(jù)。 3.通過對脈沖磁場作用下血管受力機理的深入分析,首次提出了合理選擇低
[Abstract]:At present, the biological effect of magnetic field is a hot topic in biomedical engineering. At the National Natural Science Foundation of China [1] study on the mechanism of low-intensity pulsed electromagnetic field in treating cardiovascular disease, 50077023 (2000), in charge of Luo Erping; (2) study on the mechanism of low intensity pulsed electromagnetic field in the treatment of osteoporosis, 50377044 (2003), sponsored by Luo Erping, a deep and systematic study on the biological effect of magnetic field. In this paper, the research progress of the biological effect of magnetic field is reviewed. Through the establishment of animal models and cell culture in vitro, the physiological, biochemical, immunological, biomechanical and other indicators were further examined. The impact of low intensity pulsed magnetic field on the body was studied with cardiovascular disease and osteoporosis as the breakthrough point. To explore the mechanism of the biological effect of magnetic field in order to provide new ideas and theoretical basis for the prevention and treatment of cardiovascular diseases and osteoporosis. The main work is summarized as follows: 1. Based on coherent electric oscillation theory, ion penetration theory and cyclotron resonance theory, the mechanism of nonthermal biological effect of magnetic field is studied. The mechanism of interaction between magnetic field and biological system is explained: (1) the response of organism to the magnetic field under certain conditions is nonlinear, and it shows frequency specificity and power specificity "window effect"; 2 it is pointed out that the response of organism to non-thermal effect of extremely low frequency (100 Hz),) low intensity (100Gs) magnetic field is superior to that of thermal effect, and low intensity pulsed magnetic field can easily lead to non-thermal bioaccumulation effect in organism. 2. The animal models of cardiovascular diseases such as hyperlipidemia, atherosclerosis and postmenopausal osteoporosis were successfully established. The quantitative analysis of hemorheology, blood lipids, cardiac function, bone morphometry, bone mineral density, biochemistry, Immune and biomechanical indicators, combined with gross anatomy and histopathological analysis, through the rational design of the overall experimental scheme, in vivo and in vitro experiments, The effects of low intensity pulsed magnetic field on cardiovascular system and bone system were studied systematically. The mechanism of biological effect of pulsed magnetic field was discussed, which could be used to prevent cardiovascular disease and osteoporosis in clinic. Treatment provides a new way of thinking and theoretical basis. 3. Based on the deep analysis of the stress mechanism of blood vessels under the action of pulsed magnetic field, the reasonable selection of low pressure is proposed for the first time.
【學位授予單位】：西安電子科技大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R35

【引證文獻】

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本文編號：2375496