結(jié)核分枝桿菌FurB的基因表達(dá)及單克隆抗體的制備
發(fā)布時間：2018-11-21 07:08
【摘要】：結(jié)核病(tuberculosis,TB)是由結(jié)核分枝桿菌(Mycobacterium tuberculosis,MTB)所致的以呼吸系統(tǒng)感染為主的慢性傳染病。目前全球每年有800萬新感染患者和300萬患者死亡,表明TB仍是影響全球人類健康的一個主要公共衛(wèi)生問題。近年來,由于耐藥MTB流行無高效新藥、MTB毒力相關(guān)因子研究較少、預(yù)防疫苗卡介苗(Bacillus Calmette Guerin,BCG)保護(hù)性不完善、人類免疫缺陷病毒(Human immunodificiciency Virus,HIV)的合并感染以及人口流動等原因使TB疫情日益嚴(yán)重。 MTB在結(jié)核病患者體內(nèi)的生長及致病與很多微量元素有關(guān)。其中,鐵是維持MTB新陳代謝所必需的營養(yǎng)物質(zhì)之一,其作為軸酶或活化劑參與許多與MTB生長密切相關(guān)的氧化還原反應(yīng)。限制鐵的利用可以延緩MTB的生長,同時鐵的利用情況可作為反映幾種毒性因子表達(dá)水平的指
[Abstract]:Tuberculosis (tuberculosis,TB) is a chronic infectious disease mainly caused by mycobacterium tuberculosis (Mycobacterium tuberculosis,MTB). At present, 8 million new infections and 3 million deaths occur in the world every year, indicating that TB is still a major public health problem affecting human health worldwide. In recent years, due to the prevalence of drug-resistant MTB without effective new drugs, the study of MTB virulence related factors is less, and the protection of BCG vaccine (Bacillus Calmette Guerin,BCG is not perfect. The co-infection of human immunodeficiency virus (Human immunodificiciency Virus,HIV) and population mobility make the TB epidemic more and more serious. The growth and pathogenesis of MTB in TB patients are related to many trace elements. Iron is one of the essential nutrients to maintain the metabolism of MTB. As an enzyme or activator iron participates in many redox reactions closely related to the growth of MTB. Limiting the use of iron can delay the growth of MTB, and the utilization of iron can be used to reflect the expression level of several toxic factors.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R392
本文編號：2346269
[Abstract]:Tuberculosis (tuberculosis,TB) is a chronic infectious disease mainly caused by mycobacterium tuberculosis (Mycobacterium tuberculosis,MTB). At present, 8 million new infections and 3 million deaths occur in the world every year, indicating that TB is still a major public health problem affecting human health worldwide. In recent years, due to the prevalence of drug-resistant MTB without effective new drugs, the study of MTB virulence related factors is less, and the protection of BCG vaccine (Bacillus Calmette Guerin,BCG is not perfect. The co-infection of human immunodeficiency virus (Human immunodificiciency Virus,HIV) and population mobility make the TB epidemic more and more serious. The growth and pathogenesis of MTB in TB patients are related to many trace elements. Iron is one of the essential nutrients to maintain the metabolism of MTB. As an enzyme or activator iron participates in many redox reactions closely related to the growth of MTB. Limiting the use of iron can delay the growth of MTB, and the utilization of iron can be used to reflect the expression level of several toxic factors.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R392
【參考文獻(xiàn)】
相關(guān)期刊論文 前7條
1 黃河清,張鳳章,許良樹;豬脾和馬脾鐵蛋白理化特性的比較[J];動物學(xué)報;1997年02期
2 李元,李別虎,白光春,范雄林,薛瑩,賈向志,莊玉輝;改良消減雜交法篩選結(jié)核分枝桿菌毒力相關(guān)基因[J];第四軍醫(yī)大學(xué)學(xué)報;2000年07期
3 李久蒂,王繼文,鐘澤璞,圖亞,董北;棕色固氮菌中一種含細(xì)胞色素b的鐵蛋白[J];中國科學(xué);1979年10期
4 黃河清，張鳳章，陳燦和，邱雪慧，許良樹，曾定;細(xì)菌鐵蛋白釋放鐵的動力學(xué)研究[J];生物物理學(xué)報;1996年01期
5 張鳳章,黃河清,林慶梅,曾潤穎,邱雪慧,黃南昌,許良樹,曾定;棕色固氮菌細(xì)菌鐵蛋白釋放鐵的動力學(xué)方程和性質(zhì)[J];生物物理學(xué)報;1998年01期
6 劉慶良,邵美琪;小鼠IgG類單克隆抗體三種純化方法的比較[J];細(xì)胞與分子免疫學(xué)雜志;1992年03期
7 姚淑敏;細(xì)菌的鐵供給研究[J];北華大學(xué)學(xué)報(自然科學(xué)版);2003年03期
，本文編號：2346269
本文鏈接：http://sikaile.net/yixuelunwen/binglixuelunwen/2346269.html
最近更新
教材專著
