【摘要】：正近年發(fā)現(xiàn)的長(zhǎng)鏈非編碼RNA(long non-coding RNA,lncRNA)在細(xì)胞生長(zhǎng)、發(fā)育、表觀(guān)遺傳學(xué)以及腫瘤和心血管疾病發(fā)生過(guò)程中,發(fā)揮重要的調(diào)控作用[1-9]。LncRNAs長(zhǎng)度為1 000～10 000個(gè)堿基,通常是多聚腺苷酸化的,受RNA聚合酶Ⅱ催化轉(zhuǎn)錄合成[3,6,7]。LncRNAs主要分布于胞核,在胞漿中也有存在。很多l(xiāng)ncRNAs與組蛋白修飾、染色質(zhì)重塑和表觀(guān)遺傳效應(yīng)有關(guān)[10]。但是,表觀(guān)遺傳因子識(shí)別它們的作用機(jī)制仍然是個(gè)謎。在哺乳動(dòng)物的基因組中,lncRNAs的重要性已引起研究者的重視,lncRNAs可能在
[Abstract]:Long chain noncoding RNA (long non-coding RNA,lncRNA (RNA (long non-coding RNA,lncRNA) has been discovered in recent years in cell growth, development, epigenetics, tumorigenesis and cardiovascular disease. [1-9] .The length of LncRNAs is 1 000 ~ 10 000 bases, usually polyadenosylated, and transcriptional synthesis is catalyzed by RNA polymerase 鈪，

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