溶藻弧菌抗獨(dú)特型抗體基因工程疫苗的研究
發(fā)布時(shí)間：2018-10-21 13:55
【摘要】：魚(yú)病已成為水產(chǎn)養(yǎng)殖業(yè)發(fā)展的主要障礙,制約著水產(chǎn)養(yǎng)殖業(yè)的發(fā)展。魚(yú)病的現(xiàn)有防治方法多使用各種化學(xué)藥物、抗生素和減毒、滅活疫苗�？股氐拈L(zhǎng)期使用易使魚(yú)類產(chǎn)生耐藥性,而且抗生素的殘留會(huì)通過(guò)食物鏈對(duì)人類造成危害。而現(xiàn)有的傳統(tǒng)疫苗的安全性難以掌握。滅活疫苗由于使用物理、化學(xué)的方法滅活,在制備過(guò)程中抗原活性有可能受到破壞,并且殘留的細(xì)菌內(nèi)毒素及其它雜質(zhì)可能會(huì)使魚(yú)體出現(xiàn)炎癥而死亡。減毒疫苗保留的部分毒性會(huì)影響周圍環(huán)境的生物。國(guó)內(nèi)外水產(chǎn)科技工作者正積極尋求防治效果好,安全性高,不產(chǎn)生抗藥性,無(wú)藥物殘留,而且不會(huì)造成環(huán)境污染的防治魚(yú)病方法。 國(guó)外已有新型疫苗出現(xiàn),如核酸疫苗,合成肽疫苗及抗獨(dú)特型抗體疫苗等,但這些新型疫苗在安全性、廉價(jià)性等方面各有優(yōu)勢(shì)也各有缺陷,由于各種原因目前還停留在實(shí)驗(yàn)室階段而未能大量用于養(yǎng)殖漁業(yè)。目前對(duì)于抗獨(dú)特型抗體疫苗作為新一代疫苗日益受到重視。針對(duì)
[Abstract]:Fish disease has become a major obstacle to the development of aquaculture, restricting the development of aquaculture. The existing prevention and cure methods of fish disease mostly use all kinds of chemical drugs, antibiotics and attenuated, inactivated vaccine. Long-term use of antibiotics makes fish resistant, and antibiotic residues can harm humans through the food chain. The safety of existing traditional vaccines is difficult to grasp. Due to the inactivation of the inactivated vaccine by physical and chemical methods, the antigen activity may be destroyed during the preparation process, and the residual bacterial endotoxin and other impurities may cause inflammation and death in the fish body. Some of the toxicity retained by attenuated vaccines can affect the surrounding organisms. Aquatic science and technology workers at home and abroad are actively seeking to control fish disease with good control effect, high safety, no drug resistance, no drug residue, and no environmental pollution. There have been new vaccines abroad, such as nucleic acid vaccine, synthetic peptide vaccine and anti-idiotypic antibody vaccine. However, these new vaccines have their own advantages and disadvantages in terms of safety, low cost, etc. For various reasons, it is still in the laboratory stage and can not be used in aquaculture fishery. At present, more and more attention has been paid to anti-idiotypic antibody vaccine as a new generation vaccine. In response to
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類號(hào)】：R392
本文編號(hào)：2285279
[Abstract]:Fish disease has become a major obstacle to the development of aquaculture, restricting the development of aquaculture. The existing prevention and cure methods of fish disease mostly use all kinds of chemical drugs, antibiotics and attenuated, inactivated vaccine. Long-term use of antibiotics makes fish resistant, and antibiotic residues can harm humans through the food chain. The safety of existing traditional vaccines is difficult to grasp. Due to the inactivation of the inactivated vaccine by physical and chemical methods, the antigen activity may be destroyed during the preparation process, and the residual bacterial endotoxin and other impurities may cause inflammation and death in the fish body. Some of the toxicity retained by attenuated vaccines can affect the surrounding organisms. Aquatic science and technology workers at home and abroad are actively seeking to control fish disease with good control effect, high safety, no drug resistance, no drug residue, and no environmental pollution. There have been new vaccines abroad, such as nucleic acid vaccine, synthetic peptide vaccine and anti-idiotypic antibody vaccine. However, these new vaccines have their own advantages and disadvantages in terms of safety, low cost, etc. For various reasons, it is still in the laboratory stage and can not be used in aquaculture fishery. At present, more and more attention has been paid to anti-idiotypic antibody vaccine as a new generation vaccine. In response to
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類號(hào)】：R392
【引證文獻(xiàn)】
相關(guān)期刊論文 前1條
1 李淑娜;蔣文燦;鄭維維;劉義鈴;;抗獨(dú)特型疫苗在獸醫(yī)領(lǐng)域的研究進(jìn)展[J];動(dòng)物醫(yī)學(xué)進(jìn)展;2008年02期
，本文編號(hào)：2285279
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