【摘要】：周?chē)窠?jīng)作為聯(lián)系中樞神經(jīng)系統(tǒng)(central nervous system，CNS)與外周感受器或者效應(yīng)器之間的橋梁，在神經(jīng)傳遞、神經(jīng)營(yíng)養(yǎng)等方面發(fā)揮著重要作用。由于其分布廣泛的特點(diǎn)，常因外傷、壓迫及缺血而損傷。以往的研究表明，周?chē)窠?jīng)損傷能夠引起受損神經(jīng)元(包括初級(jí)傳入神經(jīng)元和運(yùn)動(dòng)神經(jīng)元)的胞體或終末內(nèi)某些神經(jīng)活性物質(zhì)及其受體的表達(dá)發(fā)生一系列變化，其中與神經(jīng)生長(zhǎng)和營(yíng)養(yǎng)有關(guān)的物質(zhì)常發(fā)生上調(diào)，而與神經(jīng)傳遞有關(guān)的物質(zhì)則發(fā)生下調(diào)；與此同時(shí)，受損神經(jīng)元的周?chē)０殡S發(fā)生膠質(zhì)反應(yīng)及神經(jīng)膠質(zhì)增生等變化。所有這些變化被認(rèn)為是神經(jīng)元對(duì)其所受損傷的一種適應(yīng)性反應(yīng)。 谷氨酸(glutamate，Glu)是初級(jí)傳入纖維內(nèi)重要的神經(jīng)遞質(zhì)，，Glu在神經(jīng)元內(nèi)合成后必須被囊泡膜谷氨酸轉(zhuǎn)運(yùn)體(vesicular glutamate transporter，VGluT)轉(zhuǎn)運(yùn)到突觸囊泡內(nèi)，才能通過(guò)胞吐作用完成突觸傳遞。目前人們已經(jīng)發(fā)現(xiàn)了三種VGluTs，即VGluT1、VGluT2和VGluT3，并認(rèn)為它們能夠作為Glu能神經(jīng)纖維終末的特異性標(biāo)記物。最近的研究顯示，傳遞觸壓覺(jué)和本體覺(jué)信息的初級(jí)傳入纖維主要表達(dá)VGluT1，而傳遞傷害性信息的初級(jí)傳入纖維主要表達(dá)VGluT2，但在初級(jí)傳入纖維中未見(jiàn)
[Abstract]:Peripheral nerves, as a bridge between the central nervous system (CNS) and peripheral receptors or effectors, play an important role in nerve transmission, neurotrophic and other aspects. The expression of some neuroactive substances and their receptors in the soma or terminals of damaged neurons (including primary afferent neurons and motor neurons) has undergone a series of changes, in which substances related to nerve growth and nutrition are often up-regulated, while substances related to nerve transmission are down-regulated; at the same time, the periphery of damaged neurons is down-regulated. All these changes are thought to be an adaptive response of neurons to the damage they cause.
Glutamate (Glu) is an important neurotransmitter in primary afferent fibers. Glu synthesized in neurons must be transported to synaptic vesicles by vesicular glutamate transporter (VGluT) to complete synaptic transmission through exocytosis. VGluT3 is considered to be a specific marker of Gluergic nerve fiber terminals. Recent studies have shown that primary afferent fibers that transmit tactile and proprioceptive information mainly express VGluT1, while primary afferent fibers that transmit noxious information mainly express VGluT2, but not in primary afferent fibers.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類(lèi)號(hào)】：R363

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 張濤;龐有旺;李金蓮;;下頜神經(jīng)切斷術(shù)后Ⅰ型囊泡膜谷氨酸轉(zhuǎn)運(yùn)體在大鼠三叉神經(jīng)復(fù)合體中表達(dá)的變化[J];解剖學(xué)報(bào);2006年01期

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